Abstract
Smoking can accelerate the consumption of the stored antioxidant vitamins and increase the oxidative stress in the hyperlipidemic patients. The study investigated the effects of combined β-carotene, vitamin C, and vitamin E on plasma antioxidant levels, erythrocyte antioxidative enzyme activities, and LDL lipid peroxides. Male hyperlipidemic smokers (35-78 years old) were randomly divided into two antioxidant supplemented groups: intervention 1 (I1, n = 22) (15 mg β-carotene/day, 500 mg vitamin C/day, and 400 mg α-tocopherol equivalent/day) and intervention 2 (I2, n = 20) (30 mg β-carotene/day, 1000 mg vitamin C/day, and 800 mg α-tocopherol equivalent/day). After 6-week supplementation, plasma β-carotene, vitamin C, vitamin E, and erythrocyte glutathione levels increased significantly by 200%, 98%, 129%, and 39%, respectively, in the I1 group, and by 209%, 216%, 197%, and 32%, respectively, in the I2 group. Plasma Fe+2 concentrations and Fe+2/Fe+3 decreased significantly in both groups. Except erythrocyte glutathione peroxidase activity in the I1 group, erythrocyte catalase, glutathione peroxidase, and superoxide dismutase activities increased significantly in both groups. Lipid peroxides in LDL decreased significantly by 56% and 72% in the I1 and I2 groups, respectively. However, the levels of plasma iron, erythrocyte glutathione, and LDL lipid peroxides, and the activities of erythrocyte antioxidative enzymes did not differ between two groups. In conclusion, combined antioxidant supplements increased plasma antioxidant levels and antioxidative enzyme activities, and lowered LDL lipid peroxides in male hyperlipidemic smokers. Higher dosage of the supplements did not have an additive effect.
| Original language | English |
|---|---|
| Pages (from-to) | 427-434 |
| Number of pages | 8 |
| Journal | Journal of Nutritional Biochemistry |
| Volume | 13 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2002 |
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Keywords
- β-Carotene
- Antioxidative enzyme
- Hyperlipidemic smokers
- Vitamin C
- Vitamin E
ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Effects of β-carotene, vitamin C and E on antioxidant status in hyperlipidemic smokers. / Chao, Jane; Huang, Chiung Hui; Wu, S. J.; Yang, Suh-Ching; Chang, Nen-Chung; Hsieh, Ming-Che; Lo, Ping Nan.
In: Journal of Nutritional Biochemistry, Vol. 13, No. 7, 2002, p. 427-434.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of β-carotene, vitamin C and E on antioxidant status in hyperlipidemic smokers
AU - Chao, Jane
AU - Huang, Chiung Hui
AU - Wu, S. J.
AU - Yang, Suh-Ching
AU - Chang, Nen-Chung
AU - Hsieh, Ming-Che
AU - Lo, Ping Nan
PY - 2002
Y1 - 2002
N2 - Smoking can accelerate the consumption of the stored antioxidant vitamins and increase the oxidative stress in the hyperlipidemic patients. The study investigated the effects of combined β-carotene, vitamin C, and vitamin E on plasma antioxidant levels, erythrocyte antioxidative enzyme activities, and LDL lipid peroxides. Male hyperlipidemic smokers (35-78 years old) were randomly divided into two antioxidant supplemented groups: intervention 1 (I1, n = 22) (15 mg β-carotene/day, 500 mg vitamin C/day, and 400 mg α-tocopherol equivalent/day) and intervention 2 (I2, n = 20) (30 mg β-carotene/day, 1000 mg vitamin C/day, and 800 mg α-tocopherol equivalent/day). After 6-week supplementation, plasma β-carotene, vitamin C, vitamin E, and erythrocyte glutathione levels increased significantly by 200%, 98%, 129%, and 39%, respectively, in the I1 group, and by 209%, 216%, 197%, and 32%, respectively, in the I2 group. Plasma Fe+2 concentrations and Fe+2/Fe+3 decreased significantly in both groups. Except erythrocyte glutathione peroxidase activity in the I1 group, erythrocyte catalase, glutathione peroxidase, and superoxide dismutase activities increased significantly in both groups. Lipid peroxides in LDL decreased significantly by 56% and 72% in the I1 and I2 groups, respectively. However, the levels of plasma iron, erythrocyte glutathione, and LDL lipid peroxides, and the activities of erythrocyte antioxidative enzymes did not differ between two groups. In conclusion, combined antioxidant supplements increased plasma antioxidant levels and antioxidative enzyme activities, and lowered LDL lipid peroxides in male hyperlipidemic smokers. Higher dosage of the supplements did not have an additive effect.
AB - Smoking can accelerate the consumption of the stored antioxidant vitamins and increase the oxidative stress in the hyperlipidemic patients. The study investigated the effects of combined β-carotene, vitamin C, and vitamin E on plasma antioxidant levels, erythrocyte antioxidative enzyme activities, and LDL lipid peroxides. Male hyperlipidemic smokers (35-78 years old) were randomly divided into two antioxidant supplemented groups: intervention 1 (I1, n = 22) (15 mg β-carotene/day, 500 mg vitamin C/day, and 400 mg α-tocopherol equivalent/day) and intervention 2 (I2, n = 20) (30 mg β-carotene/day, 1000 mg vitamin C/day, and 800 mg α-tocopherol equivalent/day). After 6-week supplementation, plasma β-carotene, vitamin C, vitamin E, and erythrocyte glutathione levels increased significantly by 200%, 98%, 129%, and 39%, respectively, in the I1 group, and by 209%, 216%, 197%, and 32%, respectively, in the I2 group. Plasma Fe+2 concentrations and Fe+2/Fe+3 decreased significantly in both groups. Except erythrocyte glutathione peroxidase activity in the I1 group, erythrocyte catalase, glutathione peroxidase, and superoxide dismutase activities increased significantly in both groups. Lipid peroxides in LDL decreased significantly by 56% and 72% in the I1 and I2 groups, respectively. However, the levels of plasma iron, erythrocyte glutathione, and LDL lipid peroxides, and the activities of erythrocyte antioxidative enzymes did not differ between two groups. In conclusion, combined antioxidant supplements increased plasma antioxidant levels and antioxidative enzyme activities, and lowered LDL lipid peroxides in male hyperlipidemic smokers. Higher dosage of the supplements did not have an additive effect.
KW - β-Carotene
KW - Antioxidative enzyme
KW - Hyperlipidemic smokers
KW - Vitamin C
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=0036306146&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036306146&partnerID=8YFLogxK
U2 - 10.1016/S0955-2863(02)00188-2
DO - 10.1016/S0955-2863(02)00188-2
M3 - Article
AN - SCOPUS:0036306146
VL - 13
SP - 427
EP - 434
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
SN - 0955-2863
IS - 7
ER -