Effectiveness of recombinant human erythropoietin, vitamin D3 and iron therapy on long-term survival of patients with end-stage renal disease receiving haemodialysis: Analysis of 702 patients after 10-year follow-up

Huan Cheng Chang, Chien Lung Chen, Te Li Chiu, Shu I. Chen, Amy Ming Fang Yen, Tony Hsiu Hsi Chen

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Few studies have been conducted to investigate the influence of recombinant human erythropoietin (rhEPO) on the long-term prognosis of end-stage renal disease (ESRD).Design: A retrospective cohort study.Setting: The largest regional hospital renowned for haemodialysis in northern Taiwan.Subjects A total of 702 ESRD patients undergoing haemodialysis between 1993 and 2002 were evaluated.Results: The rate of overall use of rhEPO, vitamin D3 or Fe therapy was 62 %. The 10-year survival rate in patients with rhEPO supplementation was statistically more favourable than that in patients without rhEPO (hazard ratio (HR) = 0.38, 95 % CI 0.30, 0.47, P <0.0001). Similar findings were noted for patients receiving vitamin D3 (HR = 0.36, 95 % CI 0.21, 0.64, P = 0.0004) and Fe (HR = 0.45, 95 % CI 0.33, 0.61, P <0.0001). After adjusting for age, education and aetiology, the administration of rhEPO resulted in statistically significant improvements in long-term survival rate either with (HR = 0.30, 95 % CI 0.22, 0.42) or without (HR = 0.48, 95 % CI 0.38, 0.61) combined use of Fe or vitamin D3.Conclusions: We demonstrated a reduction in long-term mortality related to supplementation therapy with rhEPO, vitamin D3 and Fe. The findings provide a justification for the administration of combined supplement therapy in patients undergoing haemodialysis.

Original languageEnglish
Pages (from-to)2410-2415
Number of pages6
JournalPublic Health Nutrition
Volume12
Issue number12
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • End-stage renal disease
  • Haemodialysis
  • Recombinant human erythropoietin
  • Survival

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health

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