Effectiveness of pneumococcal conjugate vaccines of different valences against invasive pneumococcal disease among children in Taiwan

A nationwide study

Wei Ju Su, Hsiu Yun Lo, Chia Hsuin Chang, Luan Yin Chang, Cheng Hsun Chiu, Ping Ing Lee, Chun Yi Lu, Yu Chia Hsieh, Mei Shu Lai, Tzou Yien Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: For the scarcity of data, we investigated the vaccine effectiveness (VE) of the combined use of pneumococcal conjugate vaccines (PCVs) of different valences against invasive pneumococcal disease (IPD) in children. Methods: We conducted a matched case-control study using the national IPD surveillance database and the national vaccination registry. Four agematched, gender-matched and neighborhood-matched controls were identified for each incident IPD case ≤5 years with disease onsets between October 2007 and December 2013. Conditional logistic regression was used to assess VE against all serotype and serotype 19A IPD. Results: In 523 cases (median age: 28.5 months; range: 2.0-69.4 months) and 2086 controls (28.7; 2.2-70.1), a similar VE against all-serotype IPD was found between PCV13 (76%; 61-85%) and combined 7-valent PCV (PCV7)/10-valent PCV (PCV10) plus PCV13 (78%; 56-89%). The VE for PCV7/PCV10 was slightly lower (48%; 32-60%). Regarding serotype 19A, a significantly reduced risk was observed for both PCV13 (82%; 63-91%) and combined PCV7/PCV10 plus PCV13 (87%; 61-96%). PCV7/PCV10 had only a borderline protective association (31%; 4-51%). For children receiving PCV13 alone, VE against all-serotype IPD did not differ between starting the dosing at ≥2 (78%; 56-89%) or <2 (74%; 51-87%) years of age. VE was 81% (69-88%) within 6 months of the last dose of PCV and 19% (95% CI: -21 to 45%) after 2 years. Conclusions: PCVs are effective against IPD during immunization with either the same or with a mixed series, but protection might be differential over time.

Original languageEnglish
Pages (from-to)e124-e133
JournalPediatric Infectious Disease Journal
Volume35
Issue number4
DOIs
Publication statusPublished - Mar 4 2016
Externally publishedYes

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Conjugate Vaccines
Pneumococcal Vaccines
Taiwan
Vaccines
Combined Vaccines
Registries
Case-Control Studies
Immunization
Vaccination
Logistic Models
Serogroup
Databases

Keywords

  • Invasive pneumococcal disease
  • Invasive pneumococcal disease surveillance
  • Matched case-control studies
  • Pneumococcal conjugate vaccine
  • Vaccine effectiveness

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Effectiveness of pneumococcal conjugate vaccines of different valences against invasive pneumococcal disease among children in Taiwan : A nationwide study. / Su, Wei Ju; Lo, Hsiu Yun; Chang, Chia Hsuin; Chang, Luan Yin; Chiu, Cheng Hsun; Lee, Ping Ing; Lu, Chun Yi; Hsieh, Yu Chia; Lai, Mei Shu; Lin, Tzou Yien.

In: Pediatric Infectious Disease Journal, Vol. 35, No. 4, 04.03.2016, p. e124-e133.

Research output: Contribution to journalArticle

Su, Wei Ju ; Lo, Hsiu Yun ; Chang, Chia Hsuin ; Chang, Luan Yin ; Chiu, Cheng Hsun ; Lee, Ping Ing ; Lu, Chun Yi ; Hsieh, Yu Chia ; Lai, Mei Shu ; Lin, Tzou Yien. / Effectiveness of pneumococcal conjugate vaccines of different valences against invasive pneumococcal disease among children in Taiwan : A nationwide study. In: Pediatric Infectious Disease Journal. 2016 ; Vol. 35, No. 4. pp. e124-e133.
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abstract = "Background: For the scarcity of data, we investigated the vaccine effectiveness (VE) of the combined use of pneumococcal conjugate vaccines (PCVs) of different valences against invasive pneumococcal disease (IPD) in children. Methods: We conducted a matched case-control study using the national IPD surveillance database and the national vaccination registry. Four agematched, gender-matched and neighborhood-matched controls were identified for each incident IPD case ≤5 years with disease onsets between October 2007 and December 2013. Conditional logistic regression was used to assess VE against all serotype and serotype 19A IPD. Results: In 523 cases (median age: 28.5 months; range: 2.0-69.4 months) and 2086 controls (28.7; 2.2-70.1), a similar VE against all-serotype IPD was found between PCV13 (76{\%}; 61-85{\%}) and combined 7-valent PCV (PCV7)/10-valent PCV (PCV10) plus PCV13 (78{\%}; 56-89{\%}). The VE for PCV7/PCV10 was slightly lower (48{\%}; 32-60{\%}). Regarding serotype 19A, a significantly reduced risk was observed for both PCV13 (82{\%}; 63-91{\%}) and combined PCV7/PCV10 plus PCV13 (87{\%}; 61-96{\%}). PCV7/PCV10 had only a borderline protective association (31{\%}; 4-51{\%}). For children receiving PCV13 alone, VE against all-serotype IPD did not differ between starting the dosing at ≥2 (78{\%}; 56-89{\%}) or <2 (74{\%}; 51-87{\%}) years of age. VE was 81{\%} (69-88{\%}) within 6 months of the last dose of PCV and 19{\%} (95{\%} CI: -21 to 45{\%}) after 2 years. Conclusions: PCVs are effective against IPD during immunization with either the same or with a mixed series, but protection might be differential over time.",
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AU - Chang, Luan Yin

AU - Chiu, Cheng Hsun

AU - Lee, Ping Ing

AU - Lu, Chun Yi

AU - Hsieh, Yu Chia

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