Effect of Z,E-butylidedephthalide on experimental choroidal neovascularization in rat and ocular blood flow in rabbits

Wei Jiang, Wun Chang Ko, Shu Huei Hsiao, George C Y Chiou

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

• Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalInternational Eye Science
Volume7
Issue number1
Publication statusPublished - Feb 2007

Fingerprint

Choroidal Neovascularization
Rabbits
Lasers
Bruch Membrane
Choroid
Fluorescein Angiography
Solid-State Lasers
Intraperitoneal Injections
Fluorescein
Microspheres
Therapeutics

Keywords

  • Age-related macular degeneration
  • Blood flow
  • Choroid
  • Neovascularization
  • Z,E-butylidedephthalide

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Effect of Z,E-butylidedephthalide on experimental choroidal neovascularization in rat and ocular blood flow in rabbits. / Jiang, Wei; Ko, Wun Chang; Hsiao, Shu Huei; Chiou, George C Y.

In: International Eye Science, Vol. 7, No. 1, 02.2007, p. 1-5.

Research output: Contribution to journalArticle

Jiang, Wei ; Ko, Wun Chang ; Hsiao, Shu Huei ; Chiou, George C Y. / Effect of Z,E-butylidedephthalide on experimental choroidal neovascularization in rat and ocular blood flow in rabbits. In: International Eye Science. 2007 ; Vol. 7, No. 1. pp. 1-5.
@article{7043dd3c5f9b4e43b7e5e5fadf6a2a1e,
title = "Effect of Z,E-butylidedephthalide on experimental choroidal neovascularization in rat and ocular blood flow in rabbits",
abstract = "• Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P",
keywords = "Age-related macular degeneration, Blood flow, Choroid, Neovascularization, Z,E-butylidedephthalide",
author = "Wei Jiang and Ko, {Wun Chang} and Hsiao, {Shu Huei} and Chiou, {George C Y}",
year = "2007",
month = "2",
language = "English",
volume = "7",
pages = "1--5",
journal = "International Eye Science",
issn = "2222-3959",
publisher = "International Journal of Ophthalmology Press",
number = "1",

}

TY - JOUR

T1 - Effect of Z,E-butylidedephthalide on experimental choroidal neovascularization in rat and ocular blood flow in rabbits

AU - Jiang, Wei

AU - Ko, Wun Chang

AU - Hsiao, Shu Huei

AU - Chiou, George C Y

PY - 2007/2

Y1 - 2007/2

N2 - • Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P

AB - • Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P

KW - Age-related macular degeneration

KW - Blood flow

KW - Choroid

KW - Neovascularization

KW - Z,E-butylidedephthalide

UR - http://www.scopus.com/inward/record.url?scp=33847704439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847704439&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33847704439

VL - 7

SP - 1

EP - 5

JO - International Eye Science

JF - International Eye Science

SN - 2222-3959

IS - 1

ER -