Effect of Z,E-butylidedephthalide on experimental choroidal neovascularization in rat and ocular blood flow in rabbits

Wei Jiang, Wun Chang Ko, Shu Huei Hsiao, George C Y Chiou

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• Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalInternational Eye Science
Issue number1
Publication statusPublished - Feb 2007



  • Age-related macular degeneration
  • Blood flow
  • Choroid
  • Neovascularization
  • Z,E-butylidedephthalide

ASJC Scopus subject areas

  • Ophthalmology

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