Effect of verapamil on long-term tachycardia-induced atrial electrical remodeling

Shih Huang Lee, Wen Chung Yu, Jun Jack Cheng, Chi Ren Hung, Yu An Ding, Mau Song Chang, Shin Ann Chen

Research output: Contribution to journalArticlepeer-review

113 Citations (Scopus)

Abstract

Background - The effect of verapamil on long-term tachycardia-induced atrial electrical remodeling has not been reported. Methods and Results - Forty-eight dogs were randomly divided into verapamil and control groups. The dogs in the verapamil group received verapamil 120 mg every day, those in the control group did not receive verapamil. Atrial effective refractory period (AERP), inducibility of atrial fibrillation (AF), and duration of AF were assessed before and after complete atrioventricular junction ablation with 1- day, 1-week, or 6-week rapid atrial pacing (780 bpm). AERP shortening, AERP dispersion, AERP maladaptation, and inducibility of AF after 1-day pacing was significantly attenuated by verapamil. However, verapamil did not have any significant effect on these parameters in the dogs with 1-week or 6-week pacing. Verapamil did not have any significant effect on the conduction velocity in the dogs with 1-day, 1-week, or 6-week pacing. Before rapid atrial pacing, verapamil significantly prolonged the duration of AF. In the dogs with 1-day pacing, the duration of AF measured immediately after termination of pacing was similar between the control and verapamil groups. However, in the dogs with 1-week or 6-week pacing, the duration of AF after pacing was significantly longer in the verapamil group. ConClusions - verapamil cannot prevent long-term (1 and 6 weeks, respectively) tachycardia- induced changes of atrial electrophysiological properties. Furthermore, verapamil increases the duration of AF in the dogs either before or after long-term rapid atrial pacing.

Original languageEnglish
Pages (from-to)200-206
Number of pages7
JournalCirculation
Volume101
Issue number2
DOIs
Publication statusPublished - Jan 18 2000
Externally publishedYes

Keywords

  • Atrium
  • Electrophysiology
  • Tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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