Effect of topiramate on intractable seizures in Taiwanese children

Sung Tse Li, Ein Yiao Shen, Nan Chang Chiu, Che Sheng Ho

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We performed a prospective study to evaluate the effect of topiramate as an adjunctive therapy in Taiwanese children with intractable partial epilepsy and generalized epilepsy. Thirty children aged from 2 to 16 years (8.5 ± 3.8 years) were enrolled in this study. Eighteen children (60.0%) had partial epilepsy, and 12 children (40.0%) had generalized epilepsy. These children were experiencing more than one seizure per month even under a stable antiepileptic regimen treatment. Topiramate was begun at 1 mg/kg·day, and the dosage was raised by 1 mg/kg·day each week. Titration continued for 4 weeks or more. The maximal dosage was 10 mg/kg·day. In children with partial epilepsy, six children (33.3%) achieved ≥ 50% frequency reduction, while eight children (44.4%) achieved a seizure-free state. In children with generalized epilepsy, including infantile spasms, four children (33.3%) achieved ≥ 50% frequency reduction, while five children (41.7%) achieved a seizure-free state. The most common adverse effect was poor appetite (10.0%). No idiosyncratic reactions to topiramate were found. Only one patient discontinued topiramate because of central hyperventilation. Topiramate can be used as an adjunctive antiepileptic drug for intractable epileptic children in Taiwan.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalActa Neurologica Taiwanica
Volume13
Issue number2
Publication statusPublished - Jun 2004

Keywords

  • Children
  • Epileptic therapy
  • Intractable epilepsy
  • Topiramate

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Li, S. T., Shen, E. Y., Chiu, N. C., & Ho, C. S. (2004). Effect of topiramate on intractable seizures in Taiwanese children. Acta Neurologica Taiwanica, 13(2), 59-63.