Abstract
We performed a prospective study to evaluate the effect of topiramate as an adjunctive therapy in Taiwanese children with intractable partial epilepsy and generalized epilepsy. Thirty children aged from 2 to 16 years (8.5 ± 3.8 years) were enrolled in this study. Eighteen children (60.0%) had partial epilepsy, and 12 children (40.0%) had generalized epilepsy. These children were experiencing more than one seizure per month even under a stable antiepileptic regimen treatment. Topiramate was begun at 1 mg/kg·day, and the dosage was raised by 1 mg/kg·day each week. Titration continued for 4 weeks or more. The maximal dosage was 10 mg/kg·day. In children with partial epilepsy, six children (33.3%) achieved ≥ 50% frequency reduction, while eight children (44.4%) achieved a seizure-free state. In children with generalized epilepsy, including infantile spasms, four children (33.3%) achieved ≥ 50% frequency reduction, while five children (41.7%) achieved a seizure-free state. The most common adverse effect was poor appetite (10.0%). No idiosyncratic reactions to topiramate were found. Only one patient discontinued topiramate because of central hyperventilation. Topiramate can be used as an adjunctive antiepileptic drug for intractable epileptic children in Taiwan.
| Original language | English |
|---|---|
| Pages (from-to) | 59-63 |
| Number of pages | 5 |
| Journal | Acta Neurologica Taiwanica |
| Volume | 13 |
| Issue number | 2 |
| Publication status | Published - Jun 2004 |
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Keywords
- Children
- Epileptic therapy
- Intractable epilepsy
- Topiramate
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Effect of topiramate on intractable seizures in Taiwanese children. / Li, Sung Tse; Shen, Ein Yiao; Chiu, Nan Chang; Ho, Che Sheng.
In: Acta Neurologica Taiwanica, Vol. 13, No. 2, 06.2004, p. 59-63.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of topiramate on intractable seizures in Taiwanese children
AU - Li, Sung Tse
AU - Shen, Ein Yiao
AU - Chiu, Nan Chang
AU - Ho, Che Sheng
PY - 2004/6
Y1 - 2004/6
N2 - We performed a prospective study to evaluate the effect of topiramate as an adjunctive therapy in Taiwanese children with intractable partial epilepsy and generalized epilepsy. Thirty children aged from 2 to 16 years (8.5 ± 3.8 years) were enrolled in this study. Eighteen children (60.0%) had partial epilepsy, and 12 children (40.0%) had generalized epilepsy. These children were experiencing more than one seizure per month even under a stable antiepileptic regimen treatment. Topiramate was begun at 1 mg/kg·day, and the dosage was raised by 1 mg/kg·day each week. Titration continued for 4 weeks or more. The maximal dosage was 10 mg/kg·day. In children with partial epilepsy, six children (33.3%) achieved ≥ 50% frequency reduction, while eight children (44.4%) achieved a seizure-free state. In children with generalized epilepsy, including infantile spasms, four children (33.3%) achieved ≥ 50% frequency reduction, while five children (41.7%) achieved a seizure-free state. The most common adverse effect was poor appetite (10.0%). No idiosyncratic reactions to topiramate were found. Only one patient discontinued topiramate because of central hyperventilation. Topiramate can be used as an adjunctive antiepileptic drug for intractable epileptic children in Taiwan.
AB - We performed a prospective study to evaluate the effect of topiramate as an adjunctive therapy in Taiwanese children with intractable partial epilepsy and generalized epilepsy. Thirty children aged from 2 to 16 years (8.5 ± 3.8 years) were enrolled in this study. Eighteen children (60.0%) had partial epilepsy, and 12 children (40.0%) had generalized epilepsy. These children were experiencing more than one seizure per month even under a stable antiepileptic regimen treatment. Topiramate was begun at 1 mg/kg·day, and the dosage was raised by 1 mg/kg·day each week. Titration continued for 4 weeks or more. The maximal dosage was 10 mg/kg·day. In children with partial epilepsy, six children (33.3%) achieved ≥ 50% frequency reduction, while eight children (44.4%) achieved a seizure-free state. In children with generalized epilepsy, including infantile spasms, four children (33.3%) achieved ≥ 50% frequency reduction, while five children (41.7%) achieved a seizure-free state. The most common adverse effect was poor appetite (10.0%). No idiosyncratic reactions to topiramate were found. Only one patient discontinued topiramate because of central hyperventilation. Topiramate can be used as an adjunctive antiepileptic drug for intractable epileptic children in Taiwan.
KW - Children
KW - Epileptic therapy
KW - Intractable epilepsy
KW - Topiramate
UR - http://www.scopus.com/inward/record.url?scp=3042794749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042794749&partnerID=8YFLogxK
M3 - Article
C2 - 15478676
AN - SCOPUS:3042794749
VL - 13
SP - 59
EP - 63
JO - Acta Neurologica Taiwanica
JF - Acta Neurologica Taiwanica
SN - 1019-6099
IS - 2
ER -