Effect of the administration of Lactobacillus paracasei subsp. paracasei NTU 101 on Peyer's patch-mediated mucosal immunity

Yueh Ting Tsai, Po Ching Cheng, Jiunn Wang Liao, Tzu Ming Pan

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The role of lactic acid bacteria in gut mucosal immunity was investigated by comparing the enhanced effects in the Peyer's patches and spleen of BALB/c mice fed daily with Lactobacillus paracasei subsp. paracasei NTU 101 for 3 to 9 weeks. After feeding with Lactobacillus, the percentage of CD4+ T cells in both Peyer's patches and the spleen was significantly increased; however, expression of CD 154 molecules, which play a pivotal role in cell-to-cell communication, on CD4+ T cells and the percentage of B220+ B cells increased only in Peyer's patches. Compared with systemic serum IgA, Peyer's patch-derived immunomodulation induced higher levels of intestinal IgA+-producing cells in the lamina propria. Our data also showed that feeding with Lactobacillus induced stronger CD4+ T cell-dendritic cell interaction, enhanced CD4+ T cell and B cell proliferation, and increased IL-1β, IL-10, IL-12, IFN-γ, and TNF-α mRNA expression in Peyer's patches, but not in the spleen. Here, we demonstrate that following Lactobacillus treatment, Peyer's patches exhibited a more distinct capacity to induce CD4+ T cell-dendritic cell interactions, lymphocyte proliferation, and cytokine secretion than the spleen, and thereby promoted greater intestinal IgA production that could enhance immunosurveillance to prevent intestinal infections or other intestinal pathologies.

Original languageEnglish
Pages (from-to)791-798
Number of pages8
JournalInternational Immunopharmacology
Volume10
Issue number7
DOIs
Publication statusPublished - Jul 2010
Externally publishedYes

Fingerprint

Peyer's Patches
Mucosal Immunity
T-Lymphocytes
Lactobacillus
Spleen
Cell Communication
Immunoglobulin A
Dendritic Cells
B-Lymphocytes
Immunologic Monitoring
Immunomodulation
Interleukin-12
Interleukin-1
Interleukin-10
Lactobacillus paracasei
Lactic Acid
Mucous Membrane
Cell Proliferation
Lymphocytes
Pathology

Keywords

  • Immunomodulation
  • Mucosal immunity
  • Peyer's patches
  • Probiotics

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology

Cite this

Effect of the administration of Lactobacillus paracasei subsp. paracasei NTU 101 on Peyer's patch-mediated mucosal immunity. / Tsai, Yueh Ting; Cheng, Po Ching; Liao, Jiunn Wang; Pan, Tzu Ming.

In: International Immunopharmacology, Vol. 10, No. 7, 07.2010, p. 791-798.

Research output: Contribution to journalArticle

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