Effect of statin therapy on mortality in patients with infective endocarditis

Ten Fang Yang, Hsi Chu, Shuo Ming Ou, Szu Yuan Li, Yung Tai Chen, Chia Jen Shih, Lung Wen Tsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of our study was to determine whether pre-emptive statin therapy was associated with improved outcome of infective endocarditis (IE). We conducted a nationwide, population-based, propensity score-matched cohort study with the Taiwan's National Health Insurance Research Database. All patients with IE between January 2000 and December 2010 were enrolled. The primary outcome was in-hospital mortality. The secondary outcome included all-cause mortality within the first 3 months, 6 months, and one year after the diagnosis of IE. Among 13,584 patients with IE, we applied propensity score-matching on a 1:4 ratio, in which 370 statin users were matched to 1,480 statin non-users. Compared with statin non-users, statin users had a significantly lower risk of in-hospital mortality (adjusted hazard ratio [aHR] 0.65, 95% confidence interval [CI], 0.49-0.86). The reduction in mortality from IE remained significant for follow-up 3 months (aHR 0.68, 95% CI, 0.53-0.88), 6 months (aHR 0.73, 95% CI, 0.58-0.91), and 12 months (aHR 0.68, 95% CI, 0.55-0.84). Statin therapy was associated with a reduced risk of ICU admission rates, shock events, the need for mechanical ventilation, but not significantly with the need for heart valvular replacement surgery. In conclusion, our study found that statin therapy is associated with a reduced risk of in-hospital and subsequent mortality of IE.

Original languageEnglish
Pages (from-to)94-99
Number of pages6
JournalAmerican Journal of Cardiology
Volume114
Issue number1
DOIs
Publication statusPublished - Jul 1 2014

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Endocarditis
Mortality
Hospital Mortality
Confidence Intervals
Propensity Score
Therapeutics
National Health Programs
Taiwan
Artificial Respiration
Shock
Cohort Studies
Databases
Research
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Yang, T. F., Chu, H., Ou, S. M., Li, S. Y., Chen, Y. T., Shih, C. J., & Tsai, L. W. (2014). Effect of statin therapy on mortality in patients with infective endocarditis. American Journal of Cardiology, 114(1), 94-99. https://doi.org/10.1016/j.amjcard.2014.03.064

Effect of statin therapy on mortality in patients with infective endocarditis. / Yang, Ten Fang; Chu, Hsi; Ou, Shuo Ming; Li, Szu Yuan; Chen, Yung Tai; Shih, Chia Jen; Tsai, Lung Wen.

In: American Journal of Cardiology, Vol. 114, No. 1, 01.07.2014, p. 94-99.

Research output: Contribution to journalArticle

Yang, TF, Chu, H, Ou, SM, Li, SY, Chen, YT, Shih, CJ & Tsai, LW 2014, 'Effect of statin therapy on mortality in patients with infective endocarditis', American Journal of Cardiology, vol. 114, no. 1, pp. 94-99. https://doi.org/10.1016/j.amjcard.2014.03.064
Yang, Ten Fang ; Chu, Hsi ; Ou, Shuo Ming ; Li, Szu Yuan ; Chen, Yung Tai ; Shih, Chia Jen ; Tsai, Lung Wen. / Effect of statin therapy on mortality in patients with infective endocarditis. In: American Journal of Cardiology. 2014 ; Vol. 114, No. 1. pp. 94-99.
@article{86942ce272b24db0b3670d1c5eb8fa8a,
title = "Effect of statin therapy on mortality in patients with infective endocarditis",
abstract = "The aim of our study was to determine whether pre-emptive statin therapy was associated with improved outcome of infective endocarditis (IE). We conducted a nationwide, population-based, propensity score-matched cohort study with the Taiwan's National Health Insurance Research Database. All patients with IE between January 2000 and December 2010 were enrolled. The primary outcome was in-hospital mortality. The secondary outcome included all-cause mortality within the first 3 months, 6 months, and one year after the diagnosis of IE. Among 13,584 patients with IE, we applied propensity score-matching on a 1:4 ratio, in which 370 statin users were matched to 1,480 statin non-users. Compared with statin non-users, statin users had a significantly lower risk of in-hospital mortality (adjusted hazard ratio [aHR] 0.65, 95{\%} confidence interval [CI], 0.49-0.86). The reduction in mortality from IE remained significant for follow-up 3 months (aHR 0.68, 95{\%} CI, 0.53-0.88), 6 months (aHR 0.73, 95{\%} CI, 0.58-0.91), and 12 months (aHR 0.68, 95{\%} CI, 0.55-0.84). Statin therapy was associated with a reduced risk of ICU admission rates, shock events, the need for mechanical ventilation, but not significantly with the need for heart valvular replacement surgery. In conclusion, our study found that statin therapy is associated with a reduced risk of in-hospital and subsequent mortality of IE.",
author = "Yang, {Ten Fang} and Hsi Chu and Ou, {Shuo Ming} and Li, {Szu Yuan} and Chen, {Yung Tai} and Shih, {Chia Jen} and Tsai, {Lung Wen}",
year = "2014",
month = "7",
day = "1",
doi = "10.1016/j.amjcard.2014.03.064",
language = "English",
volume = "114",
pages = "94--99",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Effect of statin therapy on mortality in patients with infective endocarditis

AU - Yang, Ten Fang

AU - Chu, Hsi

AU - Ou, Shuo Ming

AU - Li, Szu Yuan

AU - Chen, Yung Tai

AU - Shih, Chia Jen

AU - Tsai, Lung Wen

PY - 2014/7/1

Y1 - 2014/7/1

N2 - The aim of our study was to determine whether pre-emptive statin therapy was associated with improved outcome of infective endocarditis (IE). We conducted a nationwide, population-based, propensity score-matched cohort study with the Taiwan's National Health Insurance Research Database. All patients with IE between January 2000 and December 2010 were enrolled. The primary outcome was in-hospital mortality. The secondary outcome included all-cause mortality within the first 3 months, 6 months, and one year after the diagnosis of IE. Among 13,584 patients with IE, we applied propensity score-matching on a 1:4 ratio, in which 370 statin users were matched to 1,480 statin non-users. Compared with statin non-users, statin users had a significantly lower risk of in-hospital mortality (adjusted hazard ratio [aHR] 0.65, 95% confidence interval [CI], 0.49-0.86). The reduction in mortality from IE remained significant for follow-up 3 months (aHR 0.68, 95% CI, 0.53-0.88), 6 months (aHR 0.73, 95% CI, 0.58-0.91), and 12 months (aHR 0.68, 95% CI, 0.55-0.84). Statin therapy was associated with a reduced risk of ICU admission rates, shock events, the need for mechanical ventilation, but not significantly with the need for heart valvular replacement surgery. In conclusion, our study found that statin therapy is associated with a reduced risk of in-hospital and subsequent mortality of IE.

AB - The aim of our study was to determine whether pre-emptive statin therapy was associated with improved outcome of infective endocarditis (IE). We conducted a nationwide, population-based, propensity score-matched cohort study with the Taiwan's National Health Insurance Research Database. All patients with IE between January 2000 and December 2010 were enrolled. The primary outcome was in-hospital mortality. The secondary outcome included all-cause mortality within the first 3 months, 6 months, and one year after the diagnosis of IE. Among 13,584 patients with IE, we applied propensity score-matching on a 1:4 ratio, in which 370 statin users were matched to 1,480 statin non-users. Compared with statin non-users, statin users had a significantly lower risk of in-hospital mortality (adjusted hazard ratio [aHR] 0.65, 95% confidence interval [CI], 0.49-0.86). The reduction in mortality from IE remained significant for follow-up 3 months (aHR 0.68, 95% CI, 0.53-0.88), 6 months (aHR 0.73, 95% CI, 0.58-0.91), and 12 months (aHR 0.68, 95% CI, 0.55-0.84). Statin therapy was associated with a reduced risk of ICU admission rates, shock events, the need for mechanical ventilation, but not significantly with the need for heart valvular replacement surgery. In conclusion, our study found that statin therapy is associated with a reduced risk of in-hospital and subsequent mortality of IE.

UR - http://www.scopus.com/inward/record.url?scp=84902273119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902273119&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2014.03.064

DO - 10.1016/j.amjcard.2014.03.064

M3 - Article

VL - 114

SP - 94

EP - 99

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 1

ER -