Abstract
Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.
| Original language | English |
|---|---|
| Journal | CNS Neuroscience and Therapeutics |
| DOIs | |
| Publication status | Accepted/In press - Jan 1 2019 |
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Keywords
- inhibitory control
- memory
- Parkinson's disease
- tDCS
ASJC Scopus subject areas
- Pharmacology
- Psychiatry and Mental health
- Physiology (medical)
- Pharmacology (medical)
Cite this
Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease. / Lau, Chi ieong; Liu, Mu N.; Chang, Kae Chwen; Chang, Anna; Bai, Chyi Huey; Tseng, Ching Shiang; Walsh, Vincent; Wang, Han Cheng.
In: CNS Neuroscience and Therapeutics, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease
AU - Lau, Chi ieong
AU - Liu, Mu N.
AU - Chang, Kae Chwen
AU - Chang, Anna
AU - Bai, Chyi Huey
AU - Tseng, Ching Shiang
AU - Walsh, Vincent
AU - Wang, Han Cheng
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.
AB - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.
KW - inhibitory control
KW - memory
KW - Parkinson's disease
KW - tDCS
UR - http://www.scopus.com/inward/record.url?scp=85070836130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070836130&partnerID=8YFLogxK
U2 - 10.1111/cns.13210
DO - 10.1111/cns.13210
M3 - Article
AN - SCOPUS:85070836130
JO - CNS Neuroscience and Therapeutics
JF - CNS Neuroscience and Therapeutics
SN - 1755-5930
ER -