Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Chi ieong Lau; Mu N. Liu; Kae Chwen Chang; Anna Chang; Chyi Huey Bai; Ching Shiang Tseng; Vincent Walsh; Han Cheng Wang

doi:10.1111/cns.13210

Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Chi ieong Lau, Mu N. Liu, Kae Chwen Chang, Anna Chang, Chyi Huey Bai, Ching Shiang Tseng, Vincent Walsh, Han Cheng Wang

Research output: Contribution to journal › Article

Abstract

Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

Original language	English
Journal	CNS Neuroscience and Therapeutics
DOIs	https://doi.org/10.1111/cns.13210
Publication status	Accepted/In press - Jan 1 2019

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Keywords

inhibitory control
memory
Parkinson's disease
tDCS

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health
Physiology (medical)
Pharmacology (medical)

Cite this

Lau, C. I., Liu, M. N., Chang, K. C., Chang, A., Bai, C. H., Tseng, C. S., Walsh, V., & Wang, H. C. (Accepted/In press). Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease. CNS Neuroscience and Therapeutics. https://doi.org/10.1111/cns.13210

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abstract = "Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.",

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author = "Lau, {Chi ieong} and Liu, {Mu N.} and Chang, {Kae Chwen} and Anna Chang and Bai, {Chyi Huey} and Tseng, {Ching Shiang} and Vincent Walsh and Wang, {Han Cheng}",

year = "2019",

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AU - Lau, Chi ieong

AU - Liu, Mu N.

AU - Chang, Kae Chwen

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AU - Bai, Chyi Huey

AU - Tseng, Ching Shiang

AU - Walsh, Vincent

AU - Wang, Han Cheng

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N2 - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

AB - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

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Access to Document

10.1111/cns.13210