Abstract
Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.
Original language | English |
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Journal | CNS Neuroscience and Therapeutics |
DOIs | |
Publication status | Accepted/In press - Jan 1 2019 |
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Keywords
- inhibitory control
- memory
- Parkinson's disease
- tDCS
ASJC Scopus subject areas
- Pharmacology
- Psychiatry and Mental health
- Physiology (medical)
- Pharmacology (medical)
Cite this
Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease. / Lau, Chi ieong; Liu, Mu N.; Chang, Kae Chwen; Chang, Anna; Bai, Chyi Huey; Tseng, Ching Shiang; Walsh, Vincent; Wang, Han Cheng.
In: CNS Neuroscience and Therapeutics, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease
AU - Lau, Chi ieong
AU - Liu, Mu N.
AU - Chang, Kae Chwen
AU - Chang, Anna
AU - Bai, Chyi Huey
AU - Tseng, Ching Shiang
AU - Walsh, Vincent
AU - Wang, Han Cheng
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.
AB - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.
KW - inhibitory control
KW - memory
KW - Parkinson's disease
KW - tDCS
UR - http://www.scopus.com/inward/record.url?scp=85070836130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070836130&partnerID=8YFLogxK
U2 - 10.1111/cns.13210
DO - 10.1111/cns.13210
M3 - Article
AN - SCOPUS:85070836130
JO - CNS Neuroscience and Therapeutics
JF - CNS Neuroscience and Therapeutics
SN - 1755-5930
ER -