Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Chi ieong Lau; Mu N. Liu; Kae Chwen Chang; Anna Chang; Chyi Huey Bai; Ching Shiang Tseng; Vincent Walsh; Han Cheng Wang

doi:10.1111/cns.13210

Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Chi ieong Lau, Mu N. Liu, Kae Chwen Chang, Anna Chang, Chyi Huey Bai, Ching Shiang Tseng, Vincent Walsh, Han Cheng Wang

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

Original language	English
Pages (from-to)	1237-1243
Number of pages	7
Journal	CNS Neuroscience and Therapeutics
Volume	25
Issue number	11
DOIs	https://doi.org/10.1111/cns.13210
Publication status	Accepted/In press - Jan 1 2019

Keywords

inhibitory control
memory
Parkinson's disease
tDCS

ASJC Scopus subject areas

Pharmacology
Psychiatry and Mental health
Physiology (medical)
Pharmacology (medical)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease. / Lau, Chi ieong; Liu, Mu N.; Chang, Kae Chwen; Chang, Anna; Bai, Chyi Huey; Tseng, Ching Shiang; Walsh, Vincent; Wang, Han Cheng.

In: CNS Neuroscience and Therapeutics, Vol. 25, No. 11, 01.01.2019, p. 1237-1243.

Research output: Contribution to journal › Article › peer-review

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abstract = "Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.",

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note = "Funding Information: Funding information This work was supported by the Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan [grant numbers: SKH-8302-104-DR-16 and 2019SKHADR016]. Chi-ieong Lau received research grants (SKH-8302-104-DR-16) and (2019SKHADR016) from the Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. Publisher Copyright: {\textcopyright} 2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.",

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AU - Tseng, Ching Shiang

AU - Walsh, Vincent

AU - Wang, Han Cheng

N1 - Funding Information: Funding information This work was supported by the Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan [grant numbers: SKH-8302-104-DR-16 and 2019SKHADR016]. Chi-ieong Lau received research grants (SKH-8302-104-DR-16) and (2019SKHADR016) from the Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. Publisher Copyright: © 2019 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.

PY - 2019/1/1

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N2 - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

AB - Aims: Nonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD. Methods: Ten nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions. Results: Single-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P >.05). Conclusion: Single-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

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Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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