Abstract
To study the effects of schisandrin B and sesamin mixture on carbon tetrachloride (CCl4)-induced hepatic oxidative stress in male Sprague-Dawley rats. The rats were randomly assigned to five groups: control group (olive oil injection), CCl4 group (CCl4 injection), silymarin group (CCl4 injection combined with supplementation of silymarin, 7.5 mg/kg/day), low dose group (CCl4 injection combined with supplementation of schisandrin B and sesamin mixture at a low dose, 43 mg/kg/day) and high dose group (CCl4 injection combined with the supplementation of schisandrin B and sesamin mixture at a high dose, 215 mg/kg/day). The hepatic superoxide dismutase and glutathione peroxidase activities of rats in the low dose and high dose groups were increased significantly compared with those in the CCl4 group. The hepatic reduced glutathione concentration in the silymarin, low dose and high dose groups were increased significantly (48%, 45% and 53%, respectively) when compared with those of the CCl4 group. In addition, the concentration of glutathione in the erythrocytes of the low dose group was significantly higher than the CCl4 group by 25%. These results suggest that the schisandrin B-sesamin mixture exerted a hepatoprotective effect by improving the antioxidative capacity in rats under CCl4-induced hepatic oxidative stress.
| Original language | English |
|---|---|
| Pages (from-to) | 251-256 |
| Number of pages | 6 |
| Journal | Phytotherapy Research |
| Volume | 23 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2009 |
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Keywords
- Carbon tetrachloride
- Hepatoprotective
- Oxidative stress
- Schisandrin b
- Sesamin
ASJC Scopus subject areas
- Pharmacology
- Medicine(all)
Cite this
Effect of schisandrin B and sesamin mixture on CCl4-induced hepatic oxidative stress in rats. / Chang, Chia Yu; Chen, Ya Ling; Yang, Suh-Ching; Huang, Guan Cheng; Tsi, Daniel; Huang, Chi Chang; Chen, Jiun-Rong; Li, Joe Sharg.
In: Phytotherapy Research, Vol. 23, No. 2, 02.2009, p. 251-256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of schisandrin B and sesamin mixture on CCl4-induced hepatic oxidative stress in rats
AU - Chang, Chia Yu
AU - Chen, Ya Ling
AU - Yang, Suh-Ching
AU - Huang, Guan Cheng
AU - Tsi, Daniel
AU - Huang, Chi Chang
AU - Chen, Jiun-Rong
AU - Li, Joe Sharg
PY - 2009/2
Y1 - 2009/2
N2 - To study the effects of schisandrin B and sesamin mixture on carbon tetrachloride (CCl4)-induced hepatic oxidative stress in male Sprague-Dawley rats. The rats were randomly assigned to five groups: control group (olive oil injection), CCl4 group (CCl4 injection), silymarin group (CCl4 injection combined with supplementation of silymarin, 7.5 mg/kg/day), low dose group (CCl4 injection combined with supplementation of schisandrin B and sesamin mixture at a low dose, 43 mg/kg/day) and high dose group (CCl4 injection combined with the supplementation of schisandrin B and sesamin mixture at a high dose, 215 mg/kg/day). The hepatic superoxide dismutase and glutathione peroxidase activities of rats in the low dose and high dose groups were increased significantly compared with those in the CCl4 group. The hepatic reduced glutathione concentration in the silymarin, low dose and high dose groups were increased significantly (48%, 45% and 53%, respectively) when compared with those of the CCl4 group. In addition, the concentration of glutathione in the erythrocytes of the low dose group was significantly higher than the CCl4 group by 25%. These results suggest that the schisandrin B-sesamin mixture exerted a hepatoprotective effect by improving the antioxidative capacity in rats under CCl4-induced hepatic oxidative stress.
AB - To study the effects of schisandrin B and sesamin mixture on carbon tetrachloride (CCl4)-induced hepatic oxidative stress in male Sprague-Dawley rats. The rats were randomly assigned to five groups: control group (olive oil injection), CCl4 group (CCl4 injection), silymarin group (CCl4 injection combined with supplementation of silymarin, 7.5 mg/kg/day), low dose group (CCl4 injection combined with supplementation of schisandrin B and sesamin mixture at a low dose, 43 mg/kg/day) and high dose group (CCl4 injection combined with the supplementation of schisandrin B and sesamin mixture at a high dose, 215 mg/kg/day). The hepatic superoxide dismutase and glutathione peroxidase activities of rats in the low dose and high dose groups were increased significantly compared with those in the CCl4 group. The hepatic reduced glutathione concentration in the silymarin, low dose and high dose groups were increased significantly (48%, 45% and 53%, respectively) when compared with those of the CCl4 group. In addition, the concentration of glutathione in the erythrocytes of the low dose group was significantly higher than the CCl4 group by 25%. These results suggest that the schisandrin B-sesamin mixture exerted a hepatoprotective effect by improving the antioxidative capacity in rats under CCl4-induced hepatic oxidative stress.
KW - Carbon tetrachloride
KW - Hepatoprotective
KW - Oxidative stress
KW - Schisandrin b
KW - Sesamin
UR - http://www.scopus.com/inward/record.url?scp=59449108086&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=59449108086&partnerID=8YFLogxK
U2 - 10.1002/ptr.2602
DO - 10.1002/ptr.2602
M3 - Article
C2 - 18979496
AN - SCOPUS:59449108086
VL - 23
SP - 251
EP - 256
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 2
ER -