Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones

Kunal Nepali, Kanika Kadian, Ritu Ojha, Rajni Dhiman, Atul Garg, Gagandip Singh, Abhishek Buddhiraja, Preet Mohinder Singh Bedi, Kanaya Lal Dhar

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18 Citations (Scopus)

Abstract

Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C 6-C 3-C 6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines.

Original languageEnglish
Pages (from-to)2990-2997
Number of pages8
JournalMedicinal Chemistry Research
Volume21
Issue number10
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes

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Keywords

  • Cell lines
  • Chalcones
  • Cytotoxic
  • Pyrazole

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Nepali, K., Kadian, K., Ojha, R., Dhiman, R., Garg, A., Singh, G., Buddhiraja, A., Bedi, P. M. S., & Dhar, K. L. (2012). Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones. Medicinal Chemistry Research, 21(10), 2990-2997. https://doi.org/10.1007/s00044-011-9824-9