Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones

Kunal Nepali, Kanika Kadian, Ritu Ojha, Rajni Dhiman, Atul Garg, Gagandip Singh, Abhishek Buddhiraja, Preet Mohinder Singh Bedi, Kanaya Lal Dhar

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are collectively known as chalcones. The cytotoxic potential of chalcones which consists of C 6-C 3-C 6 units gets enhanced by the incorporation of pyrazole ring as proved by our earlier studies. Thus in the present work, pyrazoles of chalcones with ring A substituted by furan, naphthalene and variety of substituted phenyl rings has been prepared and evaluated for in vitro cytotoxic activity against PC-3, OVCAR, IMR-32, HEP-2 human cancer cell lines.

Original languageEnglish
Pages (from-to)2990-2997
Number of pages8
JournalMedicinal Chemistry Research
Volume21
Issue number10
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes

Fingerprint

Chalcones
Substitution reactions
Pyrazoles
Chalcone
Ketones
Cells
Cell Line
pyrazole
Neoplasms

Keywords

  • Cell lines
  • Chalcones
  • Cytotoxic
  • Pyrazole

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones. / Nepali, Kunal; Kadian, Kanika; Ojha, Ritu; Dhiman, Rajni; Garg, Atul; Singh, Gagandip; Buddhiraja, Abhishek; Bedi, Preet Mohinder Singh; Dhar, Kanaya Lal.

In: Medicinal Chemistry Research, Vol. 21, No. 10, 01.10.2012, p. 2990-2997.

Research output: Contribution to journalArticle

Nepali, K, Kadian, K, Ojha, R, Dhiman, R, Garg, A, Singh, G, Buddhiraja, A, Bedi, PMS & Dhar, KL 2012, 'Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones', Medicinal Chemistry Research, vol. 21, no. 10, pp. 2990-2997. https://doi.org/10.1007/s00044-011-9824-9
Nepali, Kunal ; Kadian, Kanika ; Ojha, Ritu ; Dhiman, Rajni ; Garg, Atul ; Singh, Gagandip ; Buddhiraja, Abhishek ; Bedi, Preet Mohinder Singh ; Dhar, Kanaya Lal. / Effect of ring A and ring B substitution on the cytotoxic potential of pyrazole tethered chalcones. In: Medicinal Chemistry Research. 2012 ; Vol. 21, No. 10. pp. 2990-2997.
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AU - Garg, Atul

AU - Singh, Gagandip

AU - Buddhiraja, Abhishek

AU - Bedi, Preet Mohinder Singh

AU - Dhar, Kanaya Lal

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