Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

Tsung Te Chung, Chao Bin Yeh, Yi Ching Li, Shih Chi Su, Ming Hsien Chien, Shun Fa Yang, Yi Hsien Hsieh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

Original languageEnglish
Article numbere33517
JournalPLoS One
Volume7
Issue number3
DOIs
Publication statusPublished - Mar 12 2012

Fingerprint

hepatoma
Polymorphism
Hepatocellular Carcinoma
Genes
genetic polymorphism
metastasis
Nucleotides
Neoplasm Metastasis
genes
single nucleotide polymorphism
neoplasms
Single Nucleotide Polymorphism
Alleles
Cysteine
alleles
Liver Neoplasms
Taiwan
Restriction Fragment Length Polymorphisms
genotyping
cysteine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features. / Chung, Tsung Te; Yeh, Chao Bin; Li, Yi Ching; Su, Shih Chi; Chien, Ming Hsien; Yang, Shun Fa; Hsieh, Yi Hsien.

In: PLoS One, Vol. 7, No. 3, e33517, 12.03.2012.

Research output: Contribution to journalArticle

Chung, Tsung Te ; Yeh, Chao Bin ; Li, Yi Ching ; Su, Shih Chi ; Chien, Ming Hsien ; Yang, Shun Fa ; Hsieh, Yi Hsien. / Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features. In: PLoS One. 2012 ; Vol. 7, No. 3.
@article{e8a4a5b4bfcd4b089a348dc5af3f0274,
title = "Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features",
abstract = "Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95{\%} confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.",
author = "Chung, {Tsung Te} and Yeh, {Chao Bin} and Li, {Yi Ching} and Su, {Shih Chi} and Chien, {Ming Hsien} and Yang, {Shun Fa} and Hsieh, {Yi Hsien}",
year = "2012",
month = "3",
day = "12",
doi = "10.1371/journal.pone.0033517",
language = "English",
volume = "7",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

TY - JOUR

T1 - Effect of RECK gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathologic features

AU - Chung, Tsung Te

AU - Yeh, Chao Bin

AU - Li, Yi Ching

AU - Su, Shih Chi

AU - Chien, Ming Hsien

AU - Yang, Shun Fa

AU - Hsieh, Yi Hsien

PY - 2012/3/12

Y1 - 2012/3/12

N2 - Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

AB - Background: The reversion-inducing-cysteine-rich protein with Kazal motifs (RECK) down-regulation has been confirmed in numerous human cancers and is clinically associated with metastasis. This study investigates the potential associations of RECK single-nucleotide polymorphisms (SNPs) with hepatocellular carcinoma (HCC) susceptibility and its clinicopathologic characteristics. Methodology/Principal Findings: A total of 135 HCC cancer patients and 501 cancer-free controls were analyzed for four RECK SNPs (rs10814325, rs16932912, rs11788747, and rs10972727) using real-time PCR and PCR-RFLP genotyping analysis. After adjusting for other co-variants, the individuals carrying RECK promoter rs10814325 inheriting at least one C allele had a 1.85-fold [95% confidence interval (CI), 1.03-3.36] risk of developing HCC compared to TT wild type carriers. The HCC patients, who carried rs11788747 with at least one G allele, had a higher distant metastasis risk than wild type probands. Conclusions: RECK gene polymorphisms might be a risk factor increasing HCC susceptibility and distant metastasis in Taiwan.

UR - http://www.scopus.com/inward/record.url?scp=84863238896&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863238896&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0033517

DO - 10.1371/journal.pone.0033517

M3 - Article

C2 - 22428065

AN - SCOPUS:84863238896

VL - 7

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e33517

ER -