Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of intact proteoglycan as a material for supporting the cell growth and tissue regeneration was discussed. The efficacy of proteoglycan on the regulation of cell proliferation and differentiation was evaluated by introducing the intact proteoglycan instead of using the GAG or core protein alone in an in vitro cultural system. The results indicated that proteoglycans could induce the differentiation of ATDC5 cells to chondrocytes. It was found that both heparan sulfate proteoglycan (CS/DSPG) could enhance the induced differentiation of ATDC5 cells to chondrocytes by insulin. The dual effect of proteoglycan showed its potential to be used in a newly developed bio-mimic material for cartilage repair and regeneration.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1009
Number of pages1
Publication statusPublished - 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

Fingerprint

Tissue regeneration
Insulin
Cell proliferation
Cartilage
Cell growth
Proteoglycans
Repair
Proteins
Sulfates

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes. / Yang, W. C V; Chang, S. C.

Transactions - 7th World Biomaterials Congress. 2004. p. 1009.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Yang, WCV & Chang, SC 2004, Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes. in Transactions - 7th World Biomaterials Congress. pp. 1009, Transactions - 7th World Biomaterials Congress, Sydney, Australia, 5/17/04.
Yang WCV, Chang SC. Effect of proteoglycans on the differentiation of ATDC5 cells to chondrocytes. In Transactions - 7th World Biomaterials Congress. 2004. p. 1009
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