Effect of prolonged radiation exposure on the thyroid gland of residents living in 60Co-contaminated rebar buildings

Tien Chun Chang, Wei Li Chen, Wushou P. Chang, Chien Jen Chen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To evaluate prolonged low dose-rate γ-exposure effects on the thyroid glands of residents living in 60Co-contaminated steel buildings. Materials and methods: Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti-thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (≤ 15 and > 15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. Results and conclusions: The prevalence of simple goitre was related to the exposure with a dose-response relationship for males of all ages, and for females of ≤15 years. There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose-response relationship for males of ≤15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of ≤ 15 years.

Original languageEnglish
Pages (from-to)1117-1122
Number of pages6
JournalInternational Journal of Radiation Biology
Volume77
Issue number11
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Cytology
thyroid gland
Ultrasonography
radiation dosage
Antibodies
Regression analysis
Logistics
Thyroid Gland
Ultrasonics
dose response
Radiation
dosage
Steel
thyroid diseases
goiter
thyroid function
triiodothyronine
steel
Thyroid Nodule
cell biology

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

Cite this

Effect of prolonged radiation exposure on the thyroid gland of residents living in 60Co-contaminated rebar buildings. / Chang, Tien Chun; Chen, Wei Li; Chang, Wushou P.; Chen, Chien Jen.

In: International Journal of Radiation Biology, Vol. 77, No. 11, 2001, p. 1117-1122.

Research output: Contribution to journalArticle

Chang, Tien Chun ; Chen, Wei Li ; Chang, Wushou P. ; Chen, Chien Jen. / Effect of prolonged radiation exposure on the thyroid gland of residents living in 60Co-contaminated rebar buildings. In: International Journal of Radiation Biology. 2001 ; Vol. 77, No. 11. pp. 1117-1122.
@article{e6a2f69c7b884d098d72e620ccccaded,
title = "Effect of prolonged radiation exposure on the thyroid gland of residents living in 60Co-contaminated rebar buildings",
abstract = "Purpose: To evaluate prolonged low dose-rate γ-exposure effects on the thyroid glands of residents living in 60Co-contaminated steel buildings. Materials and methods: Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti-thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (≤ 15 and > 15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. Results and conclusions: The prevalence of simple goitre was related to the exposure with a dose-response relationship for males of all ages, and for females of ≤15 years. There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose-response relationship for males of ≤15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of ≤ 15 years.",
author = "Chang, {Tien Chun} and Chen, {Wei Li} and Chang, {Wushou P.} and Chen, {Chien Jen}",
year = "2001",
doi = "10.1080/09553000110073420",
language = "English",
volume = "77",
pages = "1117--1122",
journal = "International Journal of Radiation Biology",
issn = "0955-3002",
publisher = "Informa Healthcare",
number = "11",

}

TY - JOUR

T1 - Effect of prolonged radiation exposure on the thyroid gland of residents living in 60Co-contaminated rebar buildings

AU - Chang, Tien Chun

AU - Chen, Wei Li

AU - Chang, Wushou P.

AU - Chen, Chien Jen

PY - 2001

Y1 - 2001

N2 - Purpose: To evaluate prolonged low dose-rate γ-exposure effects on the thyroid glands of residents living in 60Co-contaminated steel buildings. Materials and methods: Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti-thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (≤ 15 and > 15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. Results and conclusions: The prevalence of simple goitre was related to the exposure with a dose-response relationship for males of all ages, and for females of ≤15 years. There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose-response relationship for males of ≤15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of ≤ 15 years.

AB - Purpose: To evaluate prolonged low dose-rate γ-exposure effects on the thyroid glands of residents living in 60Co-contaminated steel buildings. Materials and methods: Physical examination and ultrasonography of the thyroid, determination of thyroid function and anti-thyroid microsomal antibodies were performed for 1346 residents. Ultrasound-guided aspiration cytology was done for thyroid nodules. The study subjects were stratified by age at examination (≤ 15 and > 15 years), sex and exposure dose to the body. Dose-response data on the prevalence of various thyroid diseases were analysed by the multiple logistic regression analysis. Results and conclusions: The prevalence of simple goitre was related to the exposure with a dose-response relationship for males of all ages, and for females of ≤15 years. There was a biological gradient of thyroid cyst prevalence with the increase in exposure dose for females of all ages. The prevalence of elevated serum tri-iodothyronine level showed a dose-response relationship for males of ≤15 years. A significant increase in thyroid abnormalities with dose was observed for males of all ages, and for females of ≤ 15 years.

UR - http://www.scopus.com/inward/record.url?scp=0034766529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034766529&partnerID=8YFLogxK

U2 - 10.1080/09553000110073420

DO - 10.1080/09553000110073420

M3 - Article

C2 - 11683982

AN - SCOPUS:0034766529

VL - 77

SP - 1117

EP - 1122

JO - International Journal of Radiation Biology

JF - International Journal of Radiation Biology

SN - 0955-3002

IS - 11

ER -