Effect of pre-eclampsiaeclampsia on major cardiovascular events among peripartum women in taiwan

Yu Sheng Lin, Chao Hsiun Tang, Chen Yuan Charlie Yang, Lung Sheng Wu, Sheng Tzu Hung, Hsiao Lin Hwa, Pao Hsien Chu

Research output: Contribution to journalArticle

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Abstract

There is no large-scale population-based study to clarify the association between major adverse cardiovascular events (MACEs) and pre-eclampsia/eclampsia. A population-based Taiwanese cohort study was performed in 1,132,064 parturients from 1999 to 2003 using a dataset linking birth certificates and National Health Insurance hospital discharge data. Sociodemographic factors and obstetric complications were used in multivariate logistic regression models to determine adjusted hazard ratios of pre-eclampsia/eclampsia on risks of MACEs and mortality during pregnancy to at least the third year postpartum. Incidence rates of MACEs and all maternal mortality in women with pre-eclampsia/eclampsia were 16.21 and 40.38 per 100,000 patients per year, respectively. Women with pre-eclampsia/eclampsia had a 13.0-fold higher incidence of myocardial infarction, a 8.3-fold higher incidence of heart failure, a 14.5-fold higher incidence of stroke, a 12.6-fold higher incidence of MACEs, a 7.3-fold higher incidence of MACEs without stroke, a 2.3-fold higher incidence of MACE-related deaths, and a 6.4-fold higher incidence of overall death than women without pre-eclampsia/eclampsia. Kaplan-Meier survival curve discriminated in MACEs, nonstroke MACEs, MACE related death and overall death. In conclusion, women with pre-eclampsia/eclampsia have a significantly higher risk of MACEs, especially myocardial infarction and stroke, during pregnancy and their risk remains significant to

Original languageEnglish
Pages (from-to)325-330
Number of pages6
JournalAmerican Journal of Cardiology
Volume107
Issue number2
DOIs
Publication statusPublished - Jan 15 2011

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Peripartum Period
Taiwan
Eclampsia
Pre-Eclampsia
Incidence
Stroke
Logistic Models
Myocardial Infarction
Birth Certificates
Pregnancy
Maternal Mortality
Kaplan-Meier Estimate
National Health Programs
Postpartum Period
Population
Obstetrics
Cohort Studies
Heart Failure
Parturition
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Effect of pre-eclampsiaeclampsia on major cardiovascular events among peripartum women in taiwan. / Lin, Yu Sheng; Tang, Chao Hsiun; Yang, Chen Yuan Charlie; Wu, Lung Sheng; Hung, Sheng Tzu; Hwa, Hsiao Lin; Chu, Pao Hsien.

In: American Journal of Cardiology, Vol. 107, No. 2, 15.01.2011, p. 325-330.

Research output: Contribution to journalArticle

Lin, Yu Sheng ; Tang, Chao Hsiun ; Yang, Chen Yuan Charlie ; Wu, Lung Sheng ; Hung, Sheng Tzu ; Hwa, Hsiao Lin ; Chu, Pao Hsien. / Effect of pre-eclampsiaeclampsia on major cardiovascular events among peripartum women in taiwan. In: American Journal of Cardiology. 2011 ; Vol. 107, No. 2. pp. 325-330.
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