Abstract
Aim: To investigate the effect of epidermal growth factor (EGF) on mucosal healing in rats with duodenal ulcer. Methods: Male Sprague-Dawley rats were randomly divided into sham operation without EGF, sham operation with EGF, duodenal ulcer without EGF, or duodenal ulcer with EGF groups. Additionally, normal rats without operation served as the control group. Duodenal ulcer was induced in rats by 300 mL/L acetic acid. Rats with EGF were orally administered at a dose of 60 μg/kg/day in drinking water on the next day of operation (day 1). Healing of duodenal ulcer was detected by haematoxylin and eosin staining. Cell growth of damaged mucosa was determined by the contents of nucleic acids and proteins. The level of EGF in duodenal mucosa was measured by ELISA. Results: The pathological results showed that duodenal ulcer rats with EGF improved mucosal healing compared with those without EGF after day 5. Duodenal ulcer rats with EGF significantly increased duodenal DNA content compared with those without EGF on day 15 (6.44±0.54 mg/g vs 1.45±0.52 mg/g mucosa, P
| Original language | English |
|---|---|
| Pages (from-to) | 2261-2265 |
| Number of pages | 5 |
| Journal | World Journal of Gastroenterology |
| Volume | 9 |
| Issue number | 10 |
| Publication status | Published - Oct 2003 |
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ASJC Scopus subject areas
- Gastroenterology
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Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer. / Chao, Jane C J; Liu, Kuo Yu; Chen, Sheng-Hsuan; Fang, Chia Lang; Tsao, Chih Wei.
In: World Journal of Gastroenterology, Vol. 9, No. 10, 10.2003, p. 2261-2265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer
AU - Chao, Jane C J
AU - Liu, Kuo Yu
AU - Chen, Sheng-Hsuan
AU - Fang, Chia Lang
AU - Tsao, Chih Wei
PY - 2003/10
Y1 - 2003/10
N2 - Aim: To investigate the effect of epidermal growth factor (EGF) on mucosal healing in rats with duodenal ulcer. Methods: Male Sprague-Dawley rats were randomly divided into sham operation without EGF, sham operation with EGF, duodenal ulcer without EGF, or duodenal ulcer with EGF groups. Additionally, normal rats without operation served as the control group. Duodenal ulcer was induced in rats by 300 mL/L acetic acid. Rats with EGF were orally administered at a dose of 60 μg/kg/day in drinking water on the next day of operation (day 1). Healing of duodenal ulcer was detected by haematoxylin and eosin staining. Cell growth of damaged mucosa was determined by the contents of nucleic acids and proteins. The level of EGF in duodenal mucosa was measured by ELISA. Results: The pathological results showed that duodenal ulcer rats with EGF improved mucosal healing compared with those without EGF after day 5. Duodenal ulcer rats with EGF significantly increased duodenal DNA content compared with those without EGF on day 15 (6.44±0.54 mg/g vs 1.45±0.52 mg/g mucosa, P
AB - Aim: To investigate the effect of epidermal growth factor (EGF) on mucosal healing in rats with duodenal ulcer. Methods: Male Sprague-Dawley rats were randomly divided into sham operation without EGF, sham operation with EGF, duodenal ulcer without EGF, or duodenal ulcer with EGF groups. Additionally, normal rats without operation served as the control group. Duodenal ulcer was induced in rats by 300 mL/L acetic acid. Rats with EGF were orally administered at a dose of 60 μg/kg/day in drinking water on the next day of operation (day 1). Healing of duodenal ulcer was detected by haematoxylin and eosin staining. Cell growth of damaged mucosa was determined by the contents of nucleic acids and proteins. The level of EGF in duodenal mucosa was measured by ELISA. Results: The pathological results showed that duodenal ulcer rats with EGF improved mucosal healing compared with those without EGF after day 5. Duodenal ulcer rats with EGF significantly increased duodenal DNA content compared with those without EGF on day 15 (6.44±0.54 mg/g vs 1.45±0.52 mg/g mucosa, P
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M3 - Article
C2 - 14562389
AN - SCOPUS:0142213432
VL - 9
SP - 2261
EP - 2265
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 10
ER -