Abstract
Objective: ATF3 has traditionally been related to various inflammatory processes. Our aim was to test the statistical association between variations in the ATF3 gene and levels of nine serum inflammatory markers, including C reactive protein (CRP), in a Taiwanese population using interaction analysis. Methods: A sample population of 604 Taiwanese subjects was enrolled. Five tagging single nucleotide polymorphisms of the ATF3 gene from the Han Chinese HapMap Database were selected and genotyped. Results: With or without adjustment for clinical covariates, ATF3 genotypes were found to be associated with CRP levels but not with other inflammatory marker levels. Minor alleles of 2 of the 5 ATF3 SNPs were associated with decreased CRP levels predominantly in non-obese subjects (Bonferoni P= 0.018, and P= 0.002 for rs11571530, and rs10475, respectively). Two haplotypes inferred from the 5 SNPs, GATTA and TACCA, were also associated with increased or decreased CRP levels, respectively, in non-obese subjects (Bonferoni P= 0.012 and P= 0.01, respectively) but not in obese subjects. Interaction analysis revealed interaction of obesity with an ATF3 genotype associated with a high CRP level (interaction P= 0.006 for SNP rs10475). An effect of obesity on CRP level was also noted in haplotype interaction analysis (interaction P= 0.019 for haplotype TACCA). Conclusions: ATF3 polymorphisms are independently associated with CRP levels in Taiwanese subjects. Further, ATF3 genotypes/haplotypes interact with obesity to set CRP levels. These findings may have implications for the prediction of atherosclerotic disease.
| Original language | English |
|---|---|
| Pages (from-to) | 1026-1031 |
| Number of pages | 6 |
| Journal | Clinica Chimica Acta |
| Volume | 412 |
| Issue number | 11-12 |
| DOIs | |
| Publication status | Published - May 12 2011 |
| Externally published | Yes |
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Keywords
- ATF3 gene
- C reactive protein
- Gene association study
- Haplotype
- Interaction
- Polymorphism
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Effect of obesity on the association between ATF3 gene haplotypes and C-reactive protein level in Taiwanese. / Wu, Semon; Hsu, Lung An; Cheng, Ching Feng; Teng, Ming Sheng; Chou, Hsin Hua; Lin, Heng; Chang, Pi Yueh; Ko, Yu Lin.
In: Clinica Chimica Acta, Vol. 412, No. 11-12, 12.05.2011, p. 1026-1031.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of obesity on the association between ATF3 gene haplotypes and C-reactive protein level in Taiwanese
AU - Wu, Semon
AU - Hsu, Lung An
AU - Cheng, Ching Feng
AU - Teng, Ming Sheng
AU - Chou, Hsin Hua
AU - Lin, Heng
AU - Chang, Pi Yueh
AU - Ko, Yu Lin
PY - 2011/5/12
Y1 - 2011/5/12
N2 - Objective: ATF3 has traditionally been related to various inflammatory processes. Our aim was to test the statistical association between variations in the ATF3 gene and levels of nine serum inflammatory markers, including C reactive protein (CRP), in a Taiwanese population using interaction analysis. Methods: A sample population of 604 Taiwanese subjects was enrolled. Five tagging single nucleotide polymorphisms of the ATF3 gene from the Han Chinese HapMap Database were selected and genotyped. Results: With or without adjustment for clinical covariates, ATF3 genotypes were found to be associated with CRP levels but not with other inflammatory marker levels. Minor alleles of 2 of the 5 ATF3 SNPs were associated with decreased CRP levels predominantly in non-obese subjects (Bonferoni P= 0.018, and P= 0.002 for rs11571530, and rs10475, respectively). Two haplotypes inferred from the 5 SNPs, GATTA and TACCA, were also associated with increased or decreased CRP levels, respectively, in non-obese subjects (Bonferoni P= 0.012 and P= 0.01, respectively) but not in obese subjects. Interaction analysis revealed interaction of obesity with an ATF3 genotype associated with a high CRP level (interaction P= 0.006 for SNP rs10475). An effect of obesity on CRP level was also noted in haplotype interaction analysis (interaction P= 0.019 for haplotype TACCA). Conclusions: ATF3 polymorphisms are independently associated with CRP levels in Taiwanese subjects. Further, ATF3 genotypes/haplotypes interact with obesity to set CRP levels. These findings may have implications for the prediction of atherosclerotic disease.
AB - Objective: ATF3 has traditionally been related to various inflammatory processes. Our aim was to test the statistical association between variations in the ATF3 gene and levels of nine serum inflammatory markers, including C reactive protein (CRP), in a Taiwanese population using interaction analysis. Methods: A sample population of 604 Taiwanese subjects was enrolled. Five tagging single nucleotide polymorphisms of the ATF3 gene from the Han Chinese HapMap Database were selected and genotyped. Results: With or without adjustment for clinical covariates, ATF3 genotypes were found to be associated with CRP levels but not with other inflammatory marker levels. Minor alleles of 2 of the 5 ATF3 SNPs were associated with decreased CRP levels predominantly in non-obese subjects (Bonferoni P= 0.018, and P= 0.002 for rs11571530, and rs10475, respectively). Two haplotypes inferred from the 5 SNPs, GATTA and TACCA, were also associated with increased or decreased CRP levels, respectively, in non-obese subjects (Bonferoni P= 0.012 and P= 0.01, respectively) but not in obese subjects. Interaction analysis revealed interaction of obesity with an ATF3 genotype associated with a high CRP level (interaction P= 0.006 for SNP rs10475). An effect of obesity on CRP level was also noted in haplotype interaction analysis (interaction P= 0.019 for haplotype TACCA). Conclusions: ATF3 polymorphisms are independently associated with CRP levels in Taiwanese subjects. Further, ATF3 genotypes/haplotypes interact with obesity to set CRP levels. These findings may have implications for the prediction of atherosclerotic disease.
KW - ATF3 gene
KW - C reactive protein
KW - Gene association study
KW - Haplotype
KW - Interaction
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=79955011355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955011355&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2011.02.011
DO - 10.1016/j.cca.2011.02.011
M3 - Article
C2 - 21324310
AN - SCOPUS:79955011355
VL - 412
SP - 1026
EP - 1031
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 11-12
ER -