Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin

Yves S.Y. Hsieh, Deni Taleski, Brendan L. Wilkinson, Lakshmi C. Wijeyewickrem, Ty E. Adams, Robert N. Pike, Richard J. Payne

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage.

Original languageEnglish
Pages (from-to)1547-1549
Number of pages3
JournalChemical Communications
Volume48
Issue number10
DOIs
Publication statusPublished - Jan 11 2012
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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