Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection

Guan Ying Tseng, Hwai Jeng Lin, Hsiao Yi Lin, Chin Lin Perng, Fa Yauh Lee, Wen Ching Lo, Shyh Haw Tsay, Anna Senfen Yau Li, Full Young Chang, Shou Dong Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

BACKGROUND/AIMS: Both Helicobacter pylori and non-steroidal anti-inflammatory drugs are reported to affect gastroduodenal prostaglandin synthesis. However, their influence on gastric mucosal prostaglandins remains unclear. The aim of this study was to investigate the influence of non-steroidal anti-inflammatory drugs on mucosal prostaglandin synthesis in patients with Helicobacter pylori infection. METHODOLOGY: We enrolled 87 Helicobacter pylori-infected patients in this study (gastric ulcer: 33, duodenal ulcer: 41, and non-ulcer dyspepsia: 13). Of them, 27 patients received non-steroidal anti-inflammatory drugs. Endoscopy was performed and biospy specimens from gastric body, antrum and duodenal bulb were assessed for Helicobacter pylori and prostaglandin concentration. RESULTS: A significantly lower mucosal prostaglandin E2 level at gastric body (142.2 ± 28.1 ng/mg vs. 222.0 ± 12.4 ng/mg, mean ± SEM) and antrum (131.3 ± 26.4 ng/mg vs. 226.0 ± 19.0 ng/mg) was noted in Helicobacter pylori-infected gastric ulcer patients with non-steroidal anti-inflammatory drugs ingestion than in that of patients without non-steroidal anti-inflammatory drugs ingestion (p <0.05). Using a multivariate analysis, we found that non-steroidal anti-inflammatory drug was an independent variable affecting gastric and duodenal mucosal prostaglandin E3 synthesis in patients with Helicobacter pylori-infected gastric ulcer. CONCLUSIONS: Non-steroidal anti-inflammatory drugs decrease gastroduodenal mucosal prostaglandin E2 synthesis in gastric ulcer patients with Helicobacter pylori infection.

Original languageEnglish
Pages (from-to)1000-1004
Number of pages5
JournalHepato-Gastroenterology
Volume46
Issue number26
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Gastrointestinal Agents
Helicobacter Infections
Helicobacter pylori
Prostaglandins
Anti-Inflammatory Agents
Stomach Ulcer
Pharmaceutical Preparations
Stomach
Dinoprostone
Eating
Pyloric Antrum
Dyspepsia
Duodenal Ulcer
Endoscopy
Multivariate Analysis

Keywords

  • Helecobacter pylori
  • Non-steroidal anti-inflammatory drugs
  • Prostaglandin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection. / Tseng, Guan Ying; Lin, Hwai Jeng; Lin, Hsiao Yi; Perng, Chin Lin; Lee, Fa Yauh; Lo, Wen Ching; Tsay, Shyh Haw; Li, Anna Senfen Yau; Chang, Full Young; Lee, Shou Dong.

In: Hepato-Gastroenterology, Vol. 46, No. 26, 1999, p. 1000-1004.

Research output: Contribution to journalArticle

Tseng, GY, Lin, HJ, Lin, HY, Perng, CL, Lee, FY, Lo, WC, Tsay, SH, Li, ASY, Chang, FY & Lee, SD 1999, 'Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection', Hepato-Gastroenterology, vol. 46, no. 26, pp. 1000-1004.
Tseng, Guan Ying ; Lin, Hwai Jeng ; Lin, Hsiao Yi ; Perng, Chin Lin ; Lee, Fa Yauh ; Lo, Wen Ching ; Tsay, Shyh Haw ; Li, Anna Senfen Yau ; Chang, Full Young ; Lee, Shou Dong. / Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection. In: Hepato-Gastroenterology. 1999 ; Vol. 46, No. 26. pp. 1000-1004.
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AU - Tseng, Guan Ying

AU - Lin, Hwai Jeng

AU - Lin, Hsiao Yi

AU - Perng, Chin Lin

AU - Lee, Fa Yauh

AU - Lo, Wen Ching

AU - Tsay, Shyh Haw

AU - Li, Anna Senfen Yau

AU - Chang, Full Young

AU - Lee, Shou Dong

PY - 1999

Y1 - 1999

N2 - BACKGROUND/AIMS: Both Helicobacter pylori and non-steroidal anti-inflammatory drugs are reported to affect gastroduodenal prostaglandin synthesis. However, their influence on gastric mucosal prostaglandins remains unclear. The aim of this study was to investigate the influence of non-steroidal anti-inflammatory drugs on mucosal prostaglandin synthesis in patients with Helicobacter pylori infection. METHODOLOGY: We enrolled 87 Helicobacter pylori-infected patients in this study (gastric ulcer: 33, duodenal ulcer: 41, and non-ulcer dyspepsia: 13). Of them, 27 patients received non-steroidal anti-inflammatory drugs. Endoscopy was performed and biospy specimens from gastric body, antrum and duodenal bulb were assessed for Helicobacter pylori and prostaglandin concentration. RESULTS: A significantly lower mucosal prostaglandin E2 level at gastric body (142.2 ± 28.1 ng/mg vs. 222.0 ± 12.4 ng/mg, mean ± SEM) and antrum (131.3 ± 26.4 ng/mg vs. 226.0 ± 19.0 ng/mg) was noted in Helicobacter pylori-infected gastric ulcer patients with non-steroidal anti-inflammatory drugs ingestion than in that of patients without non-steroidal anti-inflammatory drugs ingestion (p <0.05). Using a multivariate analysis, we found that non-steroidal anti-inflammatory drug was an independent variable affecting gastric and duodenal mucosal prostaglandin E3 synthesis in patients with Helicobacter pylori-infected gastric ulcer. CONCLUSIONS: Non-steroidal anti-inflammatory drugs decrease gastroduodenal mucosal prostaglandin E2 synthesis in gastric ulcer patients with Helicobacter pylori infection.

AB - BACKGROUND/AIMS: Both Helicobacter pylori and non-steroidal anti-inflammatory drugs are reported to affect gastroduodenal prostaglandin synthesis. However, their influence on gastric mucosal prostaglandins remains unclear. The aim of this study was to investigate the influence of non-steroidal anti-inflammatory drugs on mucosal prostaglandin synthesis in patients with Helicobacter pylori infection. METHODOLOGY: We enrolled 87 Helicobacter pylori-infected patients in this study (gastric ulcer: 33, duodenal ulcer: 41, and non-ulcer dyspepsia: 13). Of them, 27 patients received non-steroidal anti-inflammatory drugs. Endoscopy was performed and biospy specimens from gastric body, antrum and duodenal bulb were assessed for Helicobacter pylori and prostaglandin concentration. RESULTS: A significantly lower mucosal prostaglandin E2 level at gastric body (142.2 ± 28.1 ng/mg vs. 222.0 ± 12.4 ng/mg, mean ± SEM) and antrum (131.3 ± 26.4 ng/mg vs. 226.0 ± 19.0 ng/mg) was noted in Helicobacter pylori-infected gastric ulcer patients with non-steroidal anti-inflammatory drugs ingestion than in that of patients without non-steroidal anti-inflammatory drugs ingestion (p <0.05). Using a multivariate analysis, we found that non-steroidal anti-inflammatory drug was an independent variable affecting gastric and duodenal mucosal prostaglandin E3 synthesis in patients with Helicobacter pylori-infected gastric ulcer. CONCLUSIONS: Non-steroidal anti-inflammatory drugs decrease gastroduodenal mucosal prostaglandin E2 synthesis in gastric ulcer patients with Helicobacter pylori infection.

KW - Helecobacter pylori

KW - Non-steroidal anti-inflammatory drugs

KW - Prostaglandin

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