Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection

Guan Ying Tseng, Hwai Jeng Lin, Hsiao Yi Lin, Chin Lin Perng, Fa Yauh Lee, Wen Ching Lo, Shyh Haw Tsay, Anna Senfen Yau Li, Full Young Chang, Shou Dong Lee

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Abstract

BACKGROUND/AIMS: Both Helicobacter pylori and non-steroidal anti-inflammatory drugs are reported to affect gastroduodenal prostaglandin synthesis. However, their influence on gastric mucosal prostaglandins remains unclear. The aim of this study was to investigate the influence of non-steroidal anti-inflammatory drugs on mucosal prostaglandin synthesis in patients with Helicobacter pylori infection. METHODOLOGY: We enrolled 87 Helicobacter pylori-infected patients in this study (gastric ulcer: 33, duodenal ulcer: 41, and non-ulcer dyspepsia: 13). Of them, 27 patients received non-steroidal anti-inflammatory drugs. Endoscopy was performed and biospy specimens from gastric body, antrum and duodenal bulb were assessed for Helicobacter pylori and prostaglandin concentration. RESULTS: A significantly lower mucosal prostaglandin E2 level at gastric body (142.2 ± 28.1 ng/mg vs. 222.0 ± 12.4 ng/mg, mean ± SEM) and antrum (131.3 ± 26.4 ng/mg vs. 226.0 ± 19.0 ng/mg) was noted in Helicobacter pylori-infected gastric ulcer patients with non-steroidal anti-inflammatory drugs ingestion than in that of patients without non-steroidal anti-inflammatory drugs ingestion (p <0.05). Using a multivariate analysis, we found that non-steroidal anti-inflammatory drug was an independent variable affecting gastric and duodenal mucosal prostaglandin E3 synthesis in patients with Helicobacter pylori-infected gastric ulcer. CONCLUSIONS: Non-steroidal anti-inflammatory drugs decrease gastroduodenal mucosal prostaglandin E2 synthesis in gastric ulcer patients with Helicobacter pylori infection.

Original languageEnglish
Pages (from-to)1000-1004
Number of pages5
JournalHepato-Gastroenterology
Volume46
Issue number26
Publication statusPublished - 1999
Externally publishedYes

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Keywords

  • Helecobacter pylori
  • Non-steroidal anti-inflammatory drugs
  • Prostaglandin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Tseng, G. Y., Lin, H. J., Lin, H. Y., Perng, C. L., Lee, F. Y., Lo, W. C., Tsay, S. H., Li, A. S. Y., Chang, F. Y., & Lee, S. D. (1999). Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection. Hepato-Gastroenterology, 46(26), 1000-1004.