Effect of nitrogen insertion on the antitussive properties of menthol and camphor

Naveen Kumar, Kunal Nepali, Sameer Sapra, Krishna Reddy V. Bijjem, Raj Kumar, Om P. Suri, Kanaya L. Dhar

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aromatic vapors of monoterpenoids such as menthol and camphor are known to possess antitussive effects for the symptomatic relief of upper respiratory tract. The lactams 10 and 11 of menthol and camphor, respectively, have been synthesised and evaluated first time for their antitussive activity in citric acid-induced cough in guinea pig model. The effect of nitrogen insertion in the chemical architecture of menthol and camphor on the antitussive activity was reflected by the significant decrease of the cough frequency and increase in the cough latency exhibited by aerosolized 10 and 11. Prior exposure of aerolsolised 10 for 5 min at different concentrations (15, 30, and 60 μg/l) significantly reduced cough response induced by citric acid and also increased latency to initial cough response. Similarly 11 has showed greater inhibitory cough response in comparison to camphor at concentrations such as 125, 250, and 500 lg/l. However, latency to initial cough response was only increased at the concentrations of 250 and 500 μg/l.

Original languageEnglish
Pages (from-to)531-537
Number of pages7
JournalMedicinal Chemistry Research
Volume21
Issue number4
DOIs
Publication statusPublished - Apr 1 2012
Externally publishedYes

Fingerprint

Antitussive Agents
Menthol
Camphor
Cough
Nitrogen
Citric Acid
Lactams
Monoterpenes
Vapors
Respiratory System
Guinea Pigs

Keywords

  • Antitussive agents
  • Camphor
  • Lactams
  • Menthol

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

Cite this

Effect of nitrogen insertion on the antitussive properties of menthol and camphor. / Kumar, Naveen; Nepali, Kunal; Sapra, Sameer; Bijjem, Krishna Reddy V.; Kumar, Raj; Suri, Om P.; Dhar, Kanaya L.

In: Medicinal Chemistry Research, Vol. 21, No. 4, 01.04.2012, p. 531-537.

Research output: Contribution to journalArticle

Kumar, Naveen ; Nepali, Kunal ; Sapra, Sameer ; Bijjem, Krishna Reddy V. ; Kumar, Raj ; Suri, Om P. ; Dhar, Kanaya L. / Effect of nitrogen insertion on the antitussive properties of menthol and camphor. In: Medicinal Chemistry Research. 2012 ; Vol. 21, No. 4. pp. 531-537.
@article{5de7c41413bd4be4bb75e3055870e3da,
title = "Effect of nitrogen insertion on the antitussive properties of menthol and camphor",
abstract = "Aromatic vapors of monoterpenoids such as menthol and camphor are known to possess antitussive effects for the symptomatic relief of upper respiratory tract. The lactams 10 and 11 of menthol and camphor, respectively, have been synthesised and evaluated first time for their antitussive activity in citric acid-induced cough in guinea pig model. The effect of nitrogen insertion in the chemical architecture of menthol and camphor on the antitussive activity was reflected by the significant decrease of the cough frequency and increase in the cough latency exhibited by aerosolized 10 and 11. Prior exposure of aerolsolised 10 for 5 min at different concentrations (15, 30, and 60 μg/l) significantly reduced cough response induced by citric acid and also increased latency to initial cough response. Similarly 11 has showed greater inhibitory cough response in comparison to camphor at concentrations such as 125, 250, and 500 lg/l. However, latency to initial cough response was only increased at the concentrations of 250 and 500 μg/l.",
keywords = "Antitussive agents, Camphor, Lactams, Menthol",
author = "Naveen Kumar and Kunal Nepali and Sameer Sapra and Bijjem, {Krishna Reddy V.} and Raj Kumar and Suri, {Om P.} and Dhar, {Kanaya L.}",
year = "2012",
month = "4",
day = "1",
doi = "10.1007/s00044-011-9560-1",
language = "English",
volume = "21",
pages = "531--537",
journal = "Medicinal Chemistry Research",
issn = "1054-2523",
publisher = "Birkhause Boston",
number = "4",

}

TY - JOUR

T1 - Effect of nitrogen insertion on the antitussive properties of menthol and camphor

AU - Kumar, Naveen

AU - Nepali, Kunal

AU - Sapra, Sameer

AU - Bijjem, Krishna Reddy V.

AU - Kumar, Raj

AU - Suri, Om P.

AU - Dhar, Kanaya L.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Aromatic vapors of monoterpenoids such as menthol and camphor are known to possess antitussive effects for the symptomatic relief of upper respiratory tract. The lactams 10 and 11 of menthol and camphor, respectively, have been synthesised and evaluated first time for their antitussive activity in citric acid-induced cough in guinea pig model. The effect of nitrogen insertion in the chemical architecture of menthol and camphor on the antitussive activity was reflected by the significant decrease of the cough frequency and increase in the cough latency exhibited by aerosolized 10 and 11. Prior exposure of aerolsolised 10 for 5 min at different concentrations (15, 30, and 60 μg/l) significantly reduced cough response induced by citric acid and also increased latency to initial cough response. Similarly 11 has showed greater inhibitory cough response in comparison to camphor at concentrations such as 125, 250, and 500 lg/l. However, latency to initial cough response was only increased at the concentrations of 250 and 500 μg/l.

AB - Aromatic vapors of monoterpenoids such as menthol and camphor are known to possess antitussive effects for the symptomatic relief of upper respiratory tract. The lactams 10 and 11 of menthol and camphor, respectively, have been synthesised and evaluated first time for their antitussive activity in citric acid-induced cough in guinea pig model. The effect of nitrogen insertion in the chemical architecture of menthol and camphor on the antitussive activity was reflected by the significant decrease of the cough frequency and increase in the cough latency exhibited by aerosolized 10 and 11. Prior exposure of aerolsolised 10 for 5 min at different concentrations (15, 30, and 60 μg/l) significantly reduced cough response induced by citric acid and also increased latency to initial cough response. Similarly 11 has showed greater inhibitory cough response in comparison to camphor at concentrations such as 125, 250, and 500 lg/l. However, latency to initial cough response was only increased at the concentrations of 250 and 500 μg/l.

KW - Antitussive agents

KW - Camphor

KW - Lactams

KW - Menthol

UR - http://www.scopus.com/inward/record.url?scp=84861892944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861892944&partnerID=8YFLogxK

U2 - 10.1007/s00044-011-9560-1

DO - 10.1007/s00044-011-9560-1

M3 - Article

AN - SCOPUS:84861892944

VL - 21

SP - 531

EP - 537

JO - Medicinal Chemistry Research

JF - Medicinal Chemistry Research

SN - 1054-2523

IS - 4

ER -