Effect of mitomycin C for combined trabeculectomy and phacoemulsification

Catherine Jui Ling Liu, Hui Chen Su, Joe Ching Kuang Chou, Wen-Ming Hsu, Jorn Hon Liu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background. To evaluate the efficacy and safety of intraoperative mitomycin C (MMC) for trabeculectomy combined with phacoemulsification (phacotrab) in patients with coexisting glaucoma and cataract. Methods. We retrospectively reviewed the charts of consecutive patients who underwent phacotrab from July, 1996, to March, 1998. The pre- and postoperative intraocular pressure (IOP), number of glaucoma medications, visual acuity (VA), and postoperative complications were compared among 22 patients (22 eyes) who received intraoperative MMC and 18 patients (18 eyes) who did not receive MMC, served as the control group. Data of age, gender, type of glaucoma, number of glaucoma medications, cup-to-disc ratio of the optic nerve and the extent of visual field defects were also evaluated. Kaplan- Meier survival analysis was used to compare the surgical success rates between two groups. Results. The mean IOP decreased from 16.1 ± 4.2 mmHg to 10.94 ± 3.6 mmHg in the MMC group, and from 18.7 ± 6.9 mmHg to 14.6 ± 1.9 mmHg in the control group at one year of follow-up. The mean postoperative IOPs were significantly lower in the MMC group than in the control group at one week, two weeks, and one, two, nine and 12 months. Postoperative mean VA log10 minimum angle of resolution (MAR) improved significantly in both groups. The mean number of medications decreased from 1.91 ± 0.75 to 0.18 ± 0.50 in the MMC group, and from 1.89 ± 0.47 to 0.72 ± 0.75 in the control group (p < 0.001 for both). The one-year complete success rate was significantly higher in the MMC group (p = 0.0038) than in the control group. No major complication was found throughout the study. Conclusions. Intraoperative MMC in phacotrab may improve postoperative filtration with less dependence on glaucoma medication. No significant adverse effects were associated with MMC application.

Original languageEnglish
Pages (from-to)28-36
Number of pages9
JournalChinese Medical Journal (Taipei)
Volume63
Issue number1
Publication statusPublished - Jan 1 2000
Externally publishedYes

Fingerprint

Trabeculectomy
Phacoemulsification
Mitomycin
Glaucoma
Control Groups
Intraocular Pressure
Visual Acuity
Kaplan-Meier Estimate
Survival Analysis
Optic Nerve
Visual Fields
Cataract
Safety

Keywords

  • Combined surgery
  • Glaucoma
  • Intraocular pressure
  • Mitomycin C
  • Phacoemulsification
  • Trabeculectomy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, C. J. L., Su, H. C., Chou, J. C. K., Hsu, W-M., & Liu, J. H. (2000). Effect of mitomycin C for combined trabeculectomy and phacoemulsification. Chinese Medical Journal (Taipei), 63(1), 28-36.

Effect of mitomycin C for combined trabeculectomy and phacoemulsification. / Liu, Catherine Jui Ling; Su, Hui Chen; Chou, Joe Ching Kuang; Hsu, Wen-Ming; Liu, Jorn Hon.

In: Chinese Medical Journal (Taipei), Vol. 63, No. 1, 01.01.2000, p. 28-36.

Research output: Contribution to journalArticle

Liu, Catherine Jui Ling ; Su, Hui Chen ; Chou, Joe Ching Kuang ; Hsu, Wen-Ming ; Liu, Jorn Hon. / Effect of mitomycin C for combined trabeculectomy and phacoemulsification. In: Chinese Medical Journal (Taipei). 2000 ; Vol. 63, No. 1. pp. 28-36.
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abstract = "Background. To evaluate the efficacy and safety of intraoperative mitomycin C (MMC) for trabeculectomy combined with phacoemulsification (phacotrab) in patients with coexisting glaucoma and cataract. Methods. We retrospectively reviewed the charts of consecutive patients who underwent phacotrab from July, 1996, to March, 1998. The pre- and postoperative intraocular pressure (IOP), number of glaucoma medications, visual acuity (VA), and postoperative complications were compared among 22 patients (22 eyes) who received intraoperative MMC and 18 patients (18 eyes) who did not receive MMC, served as the control group. Data of age, gender, type of glaucoma, number of glaucoma medications, cup-to-disc ratio of the optic nerve and the extent of visual field defects were also evaluated. Kaplan- Meier survival analysis was used to compare the surgical success rates between two groups. Results. The mean IOP decreased from 16.1 ± 4.2 mmHg to 10.94 ± 3.6 mmHg in the MMC group, and from 18.7 ± 6.9 mmHg to 14.6 ± 1.9 mmHg in the control group at one year of follow-up. The mean postoperative IOPs were significantly lower in the MMC group than in the control group at one week, two weeks, and one, two, nine and 12 months. Postoperative mean VA log10 minimum angle of resolution (MAR) improved significantly in both groups. The mean number of medications decreased from 1.91 ± 0.75 to 0.18 ± 0.50 in the MMC group, and from 1.89 ± 0.47 to 0.72 ± 0.75 in the control group (p < 0.001 for both). The one-year complete success rate was significantly higher in the MMC group (p = 0.0038) than in the control group. No major complication was found throughout the study. Conclusions. Intraoperative MMC in phacotrab may improve postoperative filtration with less dependence on glaucoma medication. No significant adverse effects were associated with MMC application.",
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AU - Liu, Jorn Hon

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N2 - Background. To evaluate the efficacy and safety of intraoperative mitomycin C (MMC) for trabeculectomy combined with phacoemulsification (phacotrab) in patients with coexisting glaucoma and cataract. Methods. We retrospectively reviewed the charts of consecutive patients who underwent phacotrab from July, 1996, to March, 1998. The pre- and postoperative intraocular pressure (IOP), number of glaucoma medications, visual acuity (VA), and postoperative complications were compared among 22 patients (22 eyes) who received intraoperative MMC and 18 patients (18 eyes) who did not receive MMC, served as the control group. Data of age, gender, type of glaucoma, number of glaucoma medications, cup-to-disc ratio of the optic nerve and the extent of visual field defects were also evaluated. Kaplan- Meier survival analysis was used to compare the surgical success rates between two groups. Results. The mean IOP decreased from 16.1 ± 4.2 mmHg to 10.94 ± 3.6 mmHg in the MMC group, and from 18.7 ± 6.9 mmHg to 14.6 ± 1.9 mmHg in the control group at one year of follow-up. The mean postoperative IOPs were significantly lower in the MMC group than in the control group at one week, two weeks, and one, two, nine and 12 months. Postoperative mean VA log10 minimum angle of resolution (MAR) improved significantly in both groups. The mean number of medications decreased from 1.91 ± 0.75 to 0.18 ± 0.50 in the MMC group, and from 1.89 ± 0.47 to 0.72 ± 0.75 in the control group (p < 0.001 for both). The one-year complete success rate was significantly higher in the MMC group (p = 0.0038) than in the control group. No major complication was found throughout the study. Conclusions. Intraoperative MMC in phacotrab may improve postoperative filtration with less dependence on glaucoma medication. No significant adverse effects were associated with MMC application.

AB - Background. To evaluate the efficacy and safety of intraoperative mitomycin C (MMC) for trabeculectomy combined with phacoemulsification (phacotrab) in patients with coexisting glaucoma and cataract. Methods. We retrospectively reviewed the charts of consecutive patients who underwent phacotrab from July, 1996, to March, 1998. The pre- and postoperative intraocular pressure (IOP), number of glaucoma medications, visual acuity (VA), and postoperative complications were compared among 22 patients (22 eyes) who received intraoperative MMC and 18 patients (18 eyes) who did not receive MMC, served as the control group. Data of age, gender, type of glaucoma, number of glaucoma medications, cup-to-disc ratio of the optic nerve and the extent of visual field defects were also evaluated. Kaplan- Meier survival analysis was used to compare the surgical success rates between two groups. Results. The mean IOP decreased from 16.1 ± 4.2 mmHg to 10.94 ± 3.6 mmHg in the MMC group, and from 18.7 ± 6.9 mmHg to 14.6 ± 1.9 mmHg in the control group at one year of follow-up. The mean postoperative IOPs were significantly lower in the MMC group than in the control group at one week, two weeks, and one, two, nine and 12 months. Postoperative mean VA log10 minimum angle of resolution (MAR) improved significantly in both groups. The mean number of medications decreased from 1.91 ± 0.75 to 0.18 ± 0.50 in the MMC group, and from 1.89 ± 0.47 to 0.72 ± 0.75 in the control group (p < 0.001 for both). The one-year complete success rate was significantly higher in the MMC group (p = 0.0038) than in the control group. No major complication was found throughout the study. Conclusions. Intraoperative MMC in phacotrab may improve postoperative filtration with less dependence on glaucoma medication. No significant adverse effects were associated with MMC application.

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KW - Intraocular pressure

KW - Mitomycin C

KW - Phacoemulsification

KW - Trabeculectomy

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