Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film

Mao-Suan Huang, Shang-Yang Yu, Pao-Chang Chiang, Bai-Hung Huang, Takashi Saito, Chien-Chia Huang, Fang-Tzu Pai, Chia-Yu Wu, Wen-Chien Lan

Research output: Contribution to journalArticle


In the present study, the piezoelectric aluminum nitride (AlN)/tantalum (Ta) (PAT) thin film was investigated as a biocompatible film and osseointegrated with biomedical devices such as implants. The stress variation on the interaction of cells with the PAT surface was investigated using osteoblast-like cells (MG-63) and fibroblast cells (NIH3T3). A singular behavior was observed on the PAT film with a (002) texture, in which the MG-63 cells were more dispersed and displayed longer and more filopodia than the NIH3T3 cells. Moreover, the MG-63 cells showed ingrowth, adherence, and proliferation on the PAT film surface. The MG-63 cells had more obvious stress variation than the NIH3T3 cells in the differentiation and proliferation. The mechanobiological reaction to cell differentiation and proliferation not only caused osseointegration, but also reduced the surface activation energy, thus enhancing bone remodeling. The formation of a nanopolycrystalline PAT film is believed to enhance the mechanobiological effect, promoting osseointegration.
Original languageEnglish
Article number645
JournalApplied Sciences (Switzerland)
Issue number2
Publication statusPublished - Jan 1 2020



  • Aluminum nitride
  • Mechanobiological effect
  • Piezoelectric film
  • Stress variation

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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