Abstract

Background: Mutans streptococci (MS) are the major causative bacteria involved in human dental decay. Habitual consumption of xylitol has been proved to reduce MS levels in saliva and plaque. Aim: To evaluate the effect of the maternal use of xylitol gum on MS reduction in infants. Design: A structured literature review and meta-analysis. A random effects model was used to assess the relative risks of the incidence of MS in the saliva or plaque of children who were 6, 9, 12, 18, and 24 months old. Results: We reviewed 11 RCTs derived from 5 research teams that included 601 mothers. Our results indicated that the incidence of MS in the saliva or plaque of the infants was significantly reduced in the xylitol group (risk ratio: 0.54; 95% confidence interval: 0.39-0.73, at 12-18 months) and (risk ratio: 0.56; 95% confidence interval: 0.40-0.79, at 36 months) compared with the control groups. The long-term effect of maternal xylitol gum exposure on their children's dental caries was controversial. Conclusion: Habitual xylitol consumption by mothers with high MS levels was associated with a significant reduction in the mother-child transmission of salivary MS.

Original languageEnglish
Pages (from-to)35-44
Number of pages10
JournalInternational Journal of Paediatric Dentistry
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Chewing Gum
Xylitol
Streptococcus mutans
Meta-Analysis
Randomized Controlled Trials
Mothers
Saliva
Dental Caries
Gingiva
Odds Ratio
Confidence Intervals
Incidence
Bacteria
Control Groups

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

@article{db122d900c554bc1ba59c2de03f457ee,
title = "Effect of maternal use of chewing gums containing xylitol on transmission of mutans streptococci in children: A meta-analysis of randomized controlled trials",
abstract = "Background: Mutans streptococci (MS) are the major causative bacteria involved in human dental decay. Habitual consumption of xylitol has been proved to reduce MS levels in saliva and plaque. Aim: To evaluate the effect of the maternal use of xylitol gum on MS reduction in infants. Design: A structured literature review and meta-analysis. A random effects model was used to assess the relative risks of the incidence of MS in the saliva or plaque of children who were 6, 9, 12, 18, and 24 months old. Results: We reviewed 11 RCTs derived from 5 research teams that included 601 mothers. Our results indicated that the incidence of MS in the saliva or plaque of the infants was significantly reduced in the xylitol group (risk ratio: 0.54; 95{\%} confidence interval: 0.39-0.73, at 12-18 months) and (risk ratio: 0.56; 95{\%} confidence interval: 0.40-0.79, at 36 months) compared with the control groups. The long-term effect of maternal xylitol gum exposure on their children's dental caries was controversial. Conclusion: Habitual xylitol consumption by mothers with high MS levels was associated with a significant reduction in the mother-child transmission of salivary MS.",
author = "Lin, {Hsi Kuei} and Fang, {Chia En} and Huang, {Mao Suan} and Cheng, {Hsin Chung} and Huang, {Tsai Wei} and Chang, {Hui Ting} and Tam, {Ka Wai}",
year = "2016",
month = "1",
day = "1",
doi = "10.1111/ipd.12155",
language = "English",
volume = "26",
pages = "35--44",
journal = "International Journal of Paediatric Dentistry",
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T1 - Effect of maternal use of chewing gums containing xylitol on transmission of mutans streptococci in children

T2 - A meta-analysis of randomized controlled trials

AU - Lin, Hsi Kuei

AU - Fang, Chia En

AU - Huang, Mao Suan

AU - Cheng, Hsin Chung

AU - Huang, Tsai Wei

AU - Chang, Hui Ting

AU - Tam, Ka Wai

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: Mutans streptococci (MS) are the major causative bacteria involved in human dental decay. Habitual consumption of xylitol has been proved to reduce MS levels in saliva and plaque. Aim: To evaluate the effect of the maternal use of xylitol gum on MS reduction in infants. Design: A structured literature review and meta-analysis. A random effects model was used to assess the relative risks of the incidence of MS in the saliva or plaque of children who were 6, 9, 12, 18, and 24 months old. Results: We reviewed 11 RCTs derived from 5 research teams that included 601 mothers. Our results indicated that the incidence of MS in the saliva or plaque of the infants was significantly reduced in the xylitol group (risk ratio: 0.54; 95% confidence interval: 0.39-0.73, at 12-18 months) and (risk ratio: 0.56; 95% confidence interval: 0.40-0.79, at 36 months) compared with the control groups. The long-term effect of maternal xylitol gum exposure on their children's dental caries was controversial. Conclusion: Habitual xylitol consumption by mothers with high MS levels was associated with a significant reduction in the mother-child transmission of salivary MS.

AB - Background: Mutans streptococci (MS) are the major causative bacteria involved in human dental decay. Habitual consumption of xylitol has been proved to reduce MS levels in saliva and plaque. Aim: To evaluate the effect of the maternal use of xylitol gum on MS reduction in infants. Design: A structured literature review and meta-analysis. A random effects model was used to assess the relative risks of the incidence of MS in the saliva or plaque of children who were 6, 9, 12, 18, and 24 months old. Results: We reviewed 11 RCTs derived from 5 research teams that included 601 mothers. Our results indicated that the incidence of MS in the saliva or plaque of the infants was significantly reduced in the xylitol group (risk ratio: 0.54; 95% confidence interval: 0.39-0.73, at 12-18 months) and (risk ratio: 0.56; 95% confidence interval: 0.40-0.79, at 36 months) compared with the control groups. The long-term effect of maternal xylitol gum exposure on their children's dental caries was controversial. Conclusion: Habitual xylitol consumption by mothers with high MS levels was associated with a significant reduction in the mother-child transmission of salivary MS.

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