Effect of mammographic service screening on stage at presentation of breast cancers in Sweden

Stephen W. Duffy, László Tabár, Tony H H Chen, Robert A. Smith, Lars Holmberg, Håkan Jonsson, Per Lenner, Lennarth Nyström, Sven Törnberg, Jan Frisell, Amy M F Yen, Li Sheng Chen, Yueh Hsiah Chiu, Chia Yuan Wu, Hui Min Wu, Chih Chung Huang, Jane Warwick, Levent Kemetli, Patrick Chou, Gunilla SvaneEdward Azavedo, Helen Grundström, Per Sundén, Karin Leifland, Kerstin Moberg, Tor Sahlstedt, Pal Bordás, Leena Starck, Stina Carlson, Håkan Laaksonen, Shahin Abdsaleh, Erik Thurfjell, Birgitta Epstein, Maria Tholin, Ewa Frodis, Ann Sundbom, Mika Wiege, Anders Åkerlund, Bengt Lundgren

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

BACKGROUND. Previous results have shown a reduction in mortality with service screening in Sweden on the order of 40%. If the rate of tumors at a later stage were similarly reduced, this would give further support to the mortality findings. METHODS. The rates of lymph node-positive cancers, of tumors >2 cm in pathological size, and of tumors of TNM stage II or worse before and after the introduction of screening were compared in 13 areas in Sweden, adjusted for changes in overall incidence during the period of study and stratified by age (40-49 and 50-69 years). RESULTS. Data were obtained on a total of 23,092 cancers and 10,177,113 person-years of observation. In women exposed to screening in the screening epoch, there was a significant 45% reduction in tumors of size >2 cm compared with the prescreening (relative risk [RR] = 0.55, 95% confidence interval [CI]: 0.46-0.66) in the 40-49 age group, and a 33% reduction in the 50-69 group (RR = 0.67, 95% CI: 0.62-0.72). For lymph node-positive and stage II+ disease, there were smaller but still significant reductions. No reduction in incidence in later-stage disease was observed in the unexposed women in the screening epoch. CONCLUSIONS. Screening has significantly and substantially reduced the rates of larger tumors and lymph node-positive breast cancer in Sweden, and the magnitude of the reduction is consistent with the reduction in breast cancer mortality.

Original languageEnglish
Pages (from-to)2205-2212
Number of pages8
JournalCancer
Volume109
Issue number11
DOIs
Publication statusPublished - Jun 1 2007
Externally publishedYes

Fingerprint

Sweden
Breast Neoplasms
Neoplasms
Lymph Nodes
Mortality
Confidence Intervals
Incidence
Age Groups
Observation

Keywords

  • Breast cancer
  • Screening
  • Sweden

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Duffy, S. W., Tabár, L., Chen, T. H. H., Smith, R. A., Holmberg, L., Jonsson, H., ... Lundgren, B. (2007). Effect of mammographic service screening on stage at presentation of breast cancers in Sweden. Cancer, 109(11), 2205-2212. https://doi.org/10.1002/cncr.22671

Effect of mammographic service screening on stage at presentation of breast cancers in Sweden. / Duffy, Stephen W.; Tabár, László; Chen, Tony H H; Smith, Robert A.; Holmberg, Lars; Jonsson, Håkan; Lenner, Per; Nyström, Lennarth; Törnberg, Sven; Frisell, Jan; Yen, Amy M F; Chen, Li Sheng; Chiu, Yueh Hsiah; Wu, Chia Yuan; Wu, Hui Min; Huang, Chih Chung; Warwick, Jane; Kemetli, Levent; Chou, Patrick; Svane, Gunilla; Azavedo, Edward; Grundström, Helen; Sundén, Per; Leifland, Karin; Moberg, Kerstin; Sahlstedt, Tor; Bordás, Pal; Starck, Leena; Carlson, Stina; Laaksonen, Håkan; Abdsaleh, Shahin; Thurfjell, Erik; Epstein, Birgitta; Tholin, Maria; Frodis, Ewa; Sundbom, Ann; Wiege, Mika; Åkerlund, Anders; Lundgren, Bengt.

In: Cancer, Vol. 109, No. 11, 01.06.2007, p. 2205-2212.

Research output: Contribution to journalArticle

Duffy, SW, Tabár, L, Chen, THH, Smith, RA, Holmberg, L, Jonsson, H, Lenner, P, Nyström, L, Törnberg, S, Frisell, J, Yen, AMF, Chen, LS, Chiu, YH, Wu, CY, Wu, HM, Huang, CC, Warwick, J, Kemetli, L, Chou, P, Svane, G, Azavedo, E, Grundström, H, Sundén, P, Leifland, K, Moberg, K, Sahlstedt, T, Bordás, P, Starck, L, Carlson, S, Laaksonen, H, Abdsaleh, S, Thurfjell, E, Epstein, B, Tholin, M, Frodis, E, Sundbom, A, Wiege, M, Åkerlund, A & Lundgren, B 2007, 'Effect of mammographic service screening on stage at presentation of breast cancers in Sweden', Cancer, vol. 109, no. 11, pp. 2205-2212. https://doi.org/10.1002/cncr.22671
Duffy SW, Tabár L, Chen THH, Smith RA, Holmberg L, Jonsson H et al. Effect of mammographic service screening on stage at presentation of breast cancers in Sweden. Cancer. 2007 Jun 1;109(11):2205-2212. https://doi.org/10.1002/cncr.22671
Duffy, Stephen W. ; Tabár, László ; Chen, Tony H H ; Smith, Robert A. ; Holmberg, Lars ; Jonsson, Håkan ; Lenner, Per ; Nyström, Lennarth ; Törnberg, Sven ; Frisell, Jan ; Yen, Amy M F ; Chen, Li Sheng ; Chiu, Yueh Hsiah ; Wu, Chia Yuan ; Wu, Hui Min ; Huang, Chih Chung ; Warwick, Jane ; Kemetli, Levent ; Chou, Patrick ; Svane, Gunilla ; Azavedo, Edward ; Grundström, Helen ; Sundén, Per ; Leifland, Karin ; Moberg, Kerstin ; Sahlstedt, Tor ; Bordás, Pal ; Starck, Leena ; Carlson, Stina ; Laaksonen, Håkan ; Abdsaleh, Shahin ; Thurfjell, Erik ; Epstein, Birgitta ; Tholin, Maria ; Frodis, Ewa ; Sundbom, Ann ; Wiege, Mika ; Åkerlund, Anders ; Lundgren, Bengt. / Effect of mammographic service screening on stage at presentation of breast cancers in Sweden. In: Cancer. 2007 ; Vol. 109, No. 11. pp. 2205-2212.
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title = "Effect of mammographic service screening on stage at presentation of breast cancers in Sweden",
abstract = "BACKGROUND. Previous results have shown a reduction in mortality with service screening in Sweden on the order of 40{\%}. If the rate of tumors at a later stage were similarly reduced, this would give further support to the mortality findings. METHODS. The rates of lymph node-positive cancers, of tumors >2 cm in pathological size, and of tumors of TNM stage II or worse before and after the introduction of screening were compared in 13 areas in Sweden, adjusted for changes in overall incidence during the period of study and stratified by age (40-49 and 50-69 years). RESULTS. Data were obtained on a total of 23,092 cancers and 10,177,113 person-years of observation. In women exposed to screening in the screening epoch, there was a significant 45{\%} reduction in tumors of size >2 cm compared with the prescreening (relative risk [RR] = 0.55, 95{\%} confidence interval [CI]: 0.46-0.66) in the 40-49 age group, and a 33{\%} reduction in the 50-69 group (RR = 0.67, 95{\%} CI: 0.62-0.72). For lymph node-positive and stage II+ disease, there were smaller but still significant reductions. No reduction in incidence in later-stage disease was observed in the unexposed women in the screening epoch. CONCLUSIONS. Screening has significantly and substantially reduced the rates of larger tumors and lymph node-positive breast cancer in Sweden, and the magnitude of the reduction is consistent with the reduction in breast cancer mortality.",
keywords = "Breast cancer, Screening, Sweden",
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T1 - Effect of mammographic service screening on stage at presentation of breast cancers in Sweden

AU - Duffy, Stephen W.

AU - Tabár, László

AU - Chen, Tony H H

AU - Smith, Robert A.

AU - Holmberg, Lars

AU - Jonsson, Håkan

AU - Lenner, Per

AU - Nyström, Lennarth

AU - Törnberg, Sven

AU - Frisell, Jan

AU - Yen, Amy M F

AU - Chen, Li Sheng

AU - Chiu, Yueh Hsiah

AU - Wu, Chia Yuan

AU - Wu, Hui Min

AU - Huang, Chih Chung

AU - Warwick, Jane

AU - Kemetli, Levent

AU - Chou, Patrick

AU - Svane, Gunilla

AU - Azavedo, Edward

AU - Grundström, Helen

AU - Sundén, Per

AU - Leifland, Karin

AU - Moberg, Kerstin

AU - Sahlstedt, Tor

AU - Bordás, Pal

AU - Starck, Leena

AU - Carlson, Stina

AU - Laaksonen, Håkan

AU - Abdsaleh, Shahin

AU - Thurfjell, Erik

AU - Epstein, Birgitta

AU - Tholin, Maria

AU - Frodis, Ewa

AU - Sundbom, Ann

AU - Wiege, Mika

AU - Åkerlund, Anders

AU - Lundgren, Bengt

PY - 2007/6/1

Y1 - 2007/6/1

N2 - BACKGROUND. Previous results have shown a reduction in mortality with service screening in Sweden on the order of 40%. If the rate of tumors at a later stage were similarly reduced, this would give further support to the mortality findings. METHODS. The rates of lymph node-positive cancers, of tumors >2 cm in pathological size, and of tumors of TNM stage II or worse before and after the introduction of screening were compared in 13 areas in Sweden, adjusted for changes in overall incidence during the period of study and stratified by age (40-49 and 50-69 years). RESULTS. Data were obtained on a total of 23,092 cancers and 10,177,113 person-years of observation. In women exposed to screening in the screening epoch, there was a significant 45% reduction in tumors of size >2 cm compared with the prescreening (relative risk [RR] = 0.55, 95% confidence interval [CI]: 0.46-0.66) in the 40-49 age group, and a 33% reduction in the 50-69 group (RR = 0.67, 95% CI: 0.62-0.72). For lymph node-positive and stage II+ disease, there were smaller but still significant reductions. No reduction in incidence in later-stage disease was observed in the unexposed women in the screening epoch. CONCLUSIONS. Screening has significantly and substantially reduced the rates of larger tumors and lymph node-positive breast cancer in Sweden, and the magnitude of the reduction is consistent with the reduction in breast cancer mortality.

AB - BACKGROUND. Previous results have shown a reduction in mortality with service screening in Sweden on the order of 40%. If the rate of tumors at a later stage were similarly reduced, this would give further support to the mortality findings. METHODS. The rates of lymph node-positive cancers, of tumors >2 cm in pathological size, and of tumors of TNM stage II or worse before and after the introduction of screening were compared in 13 areas in Sweden, adjusted for changes in overall incidence during the period of study and stratified by age (40-49 and 50-69 years). RESULTS. Data were obtained on a total of 23,092 cancers and 10,177,113 person-years of observation. In women exposed to screening in the screening epoch, there was a significant 45% reduction in tumors of size >2 cm compared with the prescreening (relative risk [RR] = 0.55, 95% confidence interval [CI]: 0.46-0.66) in the 40-49 age group, and a 33% reduction in the 50-69 group (RR = 0.67, 95% CI: 0.62-0.72). For lymph node-positive and stage II+ disease, there were smaller but still significant reductions. No reduction in incidence in later-stage disease was observed in the unexposed women in the screening epoch. CONCLUSIONS. Screening has significantly and substantially reduced the rates of larger tumors and lymph node-positive breast cancer in Sweden, and the magnitude of the reduction is consistent with the reduction in breast cancer mortality.

KW - Breast cancer

KW - Screening

KW - Sweden

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