Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression: Role of stimulation site and depression severity

Felix Bermpohl, Felipe Fregni, Paulo S. Boggio, Gregor Thut, Georg Northoff, Patricia T M Otachi, Sergio P. Rigonatti, Marco A. Marcolin, Alvaro Pascual-Leone

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Repetitive transcranial magnetic stimulation (rTMS) holds promise as a therapeutic tool in major depression. However, a means to assess the effects of a single rTMS session on mood to guide subsequent sessions would be desirable. The present study examined the effects of a single rTMS session on an affective go/no-go task known to measure emotional-cognitive deficits associated with major depression. Ten patients with an acute episode of unipolar major depression and eight partially or completely remitted (improved) patients underwent 1 Hz rTMS over the left and right dorsolateral prefrontal cortex prior to task performance. TMS over the mesial occipital cortex was used as a control. We observed significantly improved performance in depressed patients following right prefrontal rTMS. This beneficial effect declined with decreasing depression severity and tended to reverse in the improved group. Left prefrontal rTMS had no significant effect in the depressed group, but it resulted in impaired task performance in the improved group. Our findings indicate that the acute response of depressed patients to rTMS varies with the stimulation site and depression severity. Further studies are needed to determine whether the present paradigm could be used to predict antidepressant treatment success or to individualize stimulation parameters according to specific pathology.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalPsychiatry Research
Volume141
Issue number1
DOIs
Publication statusPublished - Jan 30 2006
Externally publishedYes

Fingerprint

Transcranial Magnetic Stimulation
Depression
Task Performance and Analysis
Occipital Lobe
Patient Rights
Depressive Disorder
Prefrontal Cortex
Antidepressive Agents
Pathology
Therapeutics

Keywords

  • Acute episode
  • Cognitive deficit
  • Dorsolateral prefrontal cortex
  • Improvement
  • Remission
  • Unipolar

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression : Role of stimulation site and depression severity. / Bermpohl, Felix; Fregni, Felipe; Boggio, Paulo S.; Thut, Gregor; Northoff, Georg; Otachi, Patricia T M; Rigonatti, Sergio P.; Marcolin, Marco A.; Pascual-Leone, Alvaro.

In: Psychiatry Research, Vol. 141, No. 1, 30.01.2006, p. 1-13.

Research output: Contribution to journalArticle

Bermpohl, Felix ; Fregni, Felipe ; Boggio, Paulo S. ; Thut, Gregor ; Northoff, Georg ; Otachi, Patricia T M ; Rigonatti, Sergio P. ; Marcolin, Marco A. ; Pascual-Leone, Alvaro. / Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression : Role of stimulation site and depression severity. In: Psychiatry Research. 2006 ; Vol. 141, No. 1. pp. 1-13.
@article{a3189aae9277408fa0e6529065f21023,
title = "Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression: Role of stimulation site and depression severity",
abstract = "Repetitive transcranial magnetic stimulation (rTMS) holds promise as a therapeutic tool in major depression. However, a means to assess the effects of a single rTMS session on mood to guide subsequent sessions would be desirable. The present study examined the effects of a single rTMS session on an affective go/no-go task known to measure emotional-cognitive deficits associated with major depression. Ten patients with an acute episode of unipolar major depression and eight partially or completely remitted (improved) patients underwent 1 Hz rTMS over the left and right dorsolateral prefrontal cortex prior to task performance. TMS over the mesial occipital cortex was used as a control. We observed significantly improved performance in depressed patients following right prefrontal rTMS. This beneficial effect declined with decreasing depression severity and tended to reverse in the improved group. Left prefrontal rTMS had no significant effect in the depressed group, but it resulted in impaired task performance in the improved group. Our findings indicate that the acute response of depressed patients to rTMS varies with the stimulation site and depression severity. Further studies are needed to determine whether the present paradigm could be used to predict antidepressant treatment success or to individualize stimulation parameters according to specific pathology.",
keywords = "Acute episode, Cognitive deficit, Dorsolateral prefrontal cortex, Improvement, Remission, Unipolar",
author = "Felix Bermpohl and Felipe Fregni and Boggio, {Paulo S.} and Gregor Thut and Georg Northoff and Otachi, {Patricia T M} and Rigonatti, {Sergio P.} and Marcolin, {Marco A.} and Alvaro Pascual-Leone",
year = "2006",
month = "1",
day = "30",
doi = "10.1016/j.psychres.2005.07.018",
language = "English",
volume = "141",
pages = "1--13",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Effect of low-frequency transcranial magnetic stimulation on an affective go/no-go task in patients with major depression

T2 - Role of stimulation site and depression severity

AU - Bermpohl, Felix

AU - Fregni, Felipe

AU - Boggio, Paulo S.

AU - Thut, Gregor

AU - Northoff, Georg

AU - Otachi, Patricia T M

AU - Rigonatti, Sergio P.

AU - Marcolin, Marco A.

AU - Pascual-Leone, Alvaro

PY - 2006/1/30

Y1 - 2006/1/30

N2 - Repetitive transcranial magnetic stimulation (rTMS) holds promise as a therapeutic tool in major depression. However, a means to assess the effects of a single rTMS session on mood to guide subsequent sessions would be desirable. The present study examined the effects of a single rTMS session on an affective go/no-go task known to measure emotional-cognitive deficits associated with major depression. Ten patients with an acute episode of unipolar major depression and eight partially or completely remitted (improved) patients underwent 1 Hz rTMS over the left and right dorsolateral prefrontal cortex prior to task performance. TMS over the mesial occipital cortex was used as a control. We observed significantly improved performance in depressed patients following right prefrontal rTMS. This beneficial effect declined with decreasing depression severity and tended to reverse in the improved group. Left prefrontal rTMS had no significant effect in the depressed group, but it resulted in impaired task performance in the improved group. Our findings indicate that the acute response of depressed patients to rTMS varies with the stimulation site and depression severity. Further studies are needed to determine whether the present paradigm could be used to predict antidepressant treatment success or to individualize stimulation parameters according to specific pathology.

AB - Repetitive transcranial magnetic stimulation (rTMS) holds promise as a therapeutic tool in major depression. However, a means to assess the effects of a single rTMS session on mood to guide subsequent sessions would be desirable. The present study examined the effects of a single rTMS session on an affective go/no-go task known to measure emotional-cognitive deficits associated with major depression. Ten patients with an acute episode of unipolar major depression and eight partially or completely remitted (improved) patients underwent 1 Hz rTMS over the left and right dorsolateral prefrontal cortex prior to task performance. TMS over the mesial occipital cortex was used as a control. We observed significantly improved performance in depressed patients following right prefrontal rTMS. This beneficial effect declined with decreasing depression severity and tended to reverse in the improved group. Left prefrontal rTMS had no significant effect in the depressed group, but it resulted in impaired task performance in the improved group. Our findings indicate that the acute response of depressed patients to rTMS varies with the stimulation site and depression severity. Further studies are needed to determine whether the present paradigm could be used to predict antidepressant treatment success or to individualize stimulation parameters according to specific pathology.

KW - Acute episode

KW - Cognitive deficit

KW - Dorsolateral prefrontal cortex

KW - Improvement

KW - Remission

KW - Unipolar

UR - http://www.scopus.com/inward/record.url?scp=29444435799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29444435799&partnerID=8YFLogxK

U2 - 10.1016/j.psychres.2005.07.018

DO - 10.1016/j.psychres.2005.07.018

M3 - Article

C2 - 16352348

AN - SCOPUS:29444435799

VL - 141

SP - 1

EP - 13

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

IS - 1

ER -