Effect of ischaemic preconditioning on regional release of inflammatory markers

Tsung-Ming Lee, Mei S. Lin, Chang H. Tsai, Nen Chung Chang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Systemic markers of inflammation may be increased in patients after percutaneous coronary intervention. In the present study, we evaluated whether IP (ischaemic preconditioning) attenuated inflammation by activating K ATP (ATP-sensitive potassium) channels in patients undergoing coronary angioplasty. Patients (n = 36) undergoing angioplasty of a major left coronary artery were allocated randomly to one of four groups: a control group, a group receiving nicorandil (an agonist of KATP channels), an IP group or an IP group pretreated with glibenclamide (an antagonist of K ATP channels). To measure the release of sCD40L, P-selectin and myeloperoxidase from the ischaemic region, blood samples were drawn simultaneously from the ascending aorta and the great cardiac vein before and 15 min after coronary angioplasty. At 15 min after angioplasty, a significant increase in sCD40L and P-selectin levels in the great cardiac vein in the control group was observed. IP- and nicorandil-treated patients did not show a significant change in sCD40L and P-selectin levels in response to angioplasty. However, the IP-induced attenuation of sCD40L and P-selectin release was abolished by administering glibenclamide. The change in myeloperoxidase levels mirrored those of sCD40L and P-selectin. The levels of inflammatory markers in the aorta remained stable throughout the study. Patients undergoing angioplasty had increased sCD40L and P-selectin levels in the ischaemic region. In conclusion, IP abolished angioplasty-induced myeloperoxidase release by preventing activated platelet-induced P-selectin release via a K ATP-channel-initiated pathway. Therefore, in addition to its primary effect on cardioprotection, IP may also provide beneficial anti-inflammatory effects on the interaction between platelets and neutrophils.

Original languageEnglish
Pages (from-to)267-276
Number of pages10
JournalClinical Science
Volume109
Issue number3
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Ischemic Preconditioning
P-Selectin
Angioplasty
Nicorandil
Peroxidase
KATP Channels
Glyburide
Adenosine Triphosphate
Aorta
Veins
Blood Platelets
Inflammation
Control Groups
Percutaneous Coronary Intervention
Coronary Vessels
Neutrophils
Anti-Inflammatory Agents

Keywords

  • Angioplasty
  • Coronary disease
  • Inflammation
  • Ion channels
  • Ischaemic preconditioning
  • Platelets
  • Reperfusion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of ischaemic preconditioning on regional release of inflammatory markers. / Lee, Tsung-Ming; Lin, Mei S.; Tsai, Chang H.; Chang, Nen Chung.

In: Clinical Science, Vol. 109, No. 3, 09.2005, p. 267-276.

Research output: Contribution to journalArticle

Lee, Tsung-Ming ; Lin, Mei S. ; Tsai, Chang H. ; Chang, Nen Chung. / Effect of ischaemic preconditioning on regional release of inflammatory markers. In: Clinical Science. 2005 ; Vol. 109, No. 3. pp. 267-276.
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