Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications

T. B. Sun, C. C H Yang, T. B J Kuo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Aims: There are relatively few effective methods to treat autonomic neuropathy in patients with diabetes mellitus. Our aim was to test the hypothesis that hyperbaric oxygen therapy may restore cardiac neural regulation dysfunction in diabetic individuals with foot complications. Methods: We conducted a prospective randomized controlled study in patients with diabetic foot problems. Daily heart-rate variability analysis from 5-min electrocardiography was used to evaluate the temporal change of cardiac neural regulation. The experimental group consisted of 23 subjects exposed to hyperbaric oxygen therapy of 202.65 kPa for 90 min every Monday to Friday for 4 weeks (20 treatments). The control group consisted of 15 age-, sex- and disease-matched subjects who were not exposed to hyperbaric therapy. Patients with medical complications and failure of wound healing were excluded to eliminate possible confounding effects. Results: There was no significant difference in baseline R-R interval (RR), variance, high-frequency power (HF), low-frequency power (LF), and LF/HF ratio between the two groups. In the hyperbaric oxygen group there were significant increases in changes of RR (82.7 ± 16.02 ms); variance 0.88 ± 0.12 ln(ms2); HF 1.06 ± 0.18 ln(ms2); and LF 0.87 ± 0.15 ln(ms2) after the treatment. Measurements of tissue oxygen demonstrated significant increases in local tissue oxygenation in the hyperbaric oxygen group (53.0 ± 2.6 mmHg) compared with the control group (27.5 ± 3.1 mmHg), P < 0.05. Conclusion: Hyperbaric oxygen therapy has a significant vagotonic effect, which is beneficial in improving cardiac neural regulation in patients with diabetic autonomic dysfunction.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalDiabetic Medicine
Volume23
Issue number4
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

Fingerprint

Hyperbaric Oxygenation
Foot
Oxygen
Control Groups
Diabetic Foot
Wound Healing
Diabetes Mellitus
Electrocardiography
Therapeutics
Heart Rate

Keywords

  • Autonomic neuropathy
  • Clinical studies
  • Diabetic foot
  • Heart-rate monitoring
  • Microvascular disease

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications. / Sun, T. B.; Yang, C. C H; Kuo, T. B J.

In: Diabetic Medicine, Vol. 23, No. 4, 04.2006, p. 360-366.

Research output: Contribution to journalArticle

@article{a9ca97a58daf4f79bd2f001159455e05,
title = "Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications",
abstract = "Aims: There are relatively few effective methods to treat autonomic neuropathy in patients with diabetes mellitus. Our aim was to test the hypothesis that hyperbaric oxygen therapy may restore cardiac neural regulation dysfunction in diabetic individuals with foot complications. Methods: We conducted a prospective randomized controlled study in patients with diabetic foot problems. Daily heart-rate variability analysis from 5-min electrocardiography was used to evaluate the temporal change of cardiac neural regulation. The experimental group consisted of 23 subjects exposed to hyperbaric oxygen therapy of 202.65 kPa for 90 min every Monday to Friday for 4 weeks (20 treatments). The control group consisted of 15 age-, sex- and disease-matched subjects who were not exposed to hyperbaric therapy. Patients with medical complications and failure of wound healing were excluded to eliminate possible confounding effects. Results: There was no significant difference in baseline R-R interval (RR), variance, high-frequency power (HF), low-frequency power (LF), and LF/HF ratio between the two groups. In the hyperbaric oxygen group there were significant increases in changes of RR (82.7 ± 16.02 ms); variance 0.88 ± 0.12 ln(ms2); HF 1.06 ± 0.18 ln(ms2); and LF 0.87 ± 0.15 ln(ms2) after the treatment. Measurements of tissue oxygen demonstrated significant increases in local tissue oxygenation in the hyperbaric oxygen group (53.0 ± 2.6 mmHg) compared with the control group (27.5 ± 3.1 mmHg), P < 0.05. Conclusion: Hyperbaric oxygen therapy has a significant vagotonic effect, which is beneficial in improving cardiac neural regulation in patients with diabetic autonomic dysfunction.",
keywords = "Autonomic neuropathy, Clinical studies, Diabetic foot, Heart-rate monitoring, Microvascular disease",
author = "Sun, {T. B.} and Yang, {C. C H} and Kuo, {T. B J}",
year = "2006",
month = "4",
doi = "10.1111/j.1464-5491.2006.01798.x",
language = "English",
volume = "23",
pages = "360--366",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Effect of hyperbaric oxygen on cardiac neural regulation in diabetic individuals with foot complications

AU - Sun, T. B.

AU - Yang, C. C H

AU - Kuo, T. B J

PY - 2006/4

Y1 - 2006/4

N2 - Aims: There are relatively few effective methods to treat autonomic neuropathy in patients with diabetes mellitus. Our aim was to test the hypothesis that hyperbaric oxygen therapy may restore cardiac neural regulation dysfunction in diabetic individuals with foot complications. Methods: We conducted a prospective randomized controlled study in patients with diabetic foot problems. Daily heart-rate variability analysis from 5-min electrocardiography was used to evaluate the temporal change of cardiac neural regulation. The experimental group consisted of 23 subjects exposed to hyperbaric oxygen therapy of 202.65 kPa for 90 min every Monday to Friday for 4 weeks (20 treatments). The control group consisted of 15 age-, sex- and disease-matched subjects who were not exposed to hyperbaric therapy. Patients with medical complications and failure of wound healing were excluded to eliminate possible confounding effects. Results: There was no significant difference in baseline R-R interval (RR), variance, high-frequency power (HF), low-frequency power (LF), and LF/HF ratio between the two groups. In the hyperbaric oxygen group there were significant increases in changes of RR (82.7 ± 16.02 ms); variance 0.88 ± 0.12 ln(ms2); HF 1.06 ± 0.18 ln(ms2); and LF 0.87 ± 0.15 ln(ms2) after the treatment. Measurements of tissue oxygen demonstrated significant increases in local tissue oxygenation in the hyperbaric oxygen group (53.0 ± 2.6 mmHg) compared with the control group (27.5 ± 3.1 mmHg), P < 0.05. Conclusion: Hyperbaric oxygen therapy has a significant vagotonic effect, which is beneficial in improving cardiac neural regulation in patients with diabetic autonomic dysfunction.

AB - Aims: There are relatively few effective methods to treat autonomic neuropathy in patients with diabetes mellitus. Our aim was to test the hypothesis that hyperbaric oxygen therapy may restore cardiac neural regulation dysfunction in diabetic individuals with foot complications. Methods: We conducted a prospective randomized controlled study in patients with diabetic foot problems. Daily heart-rate variability analysis from 5-min electrocardiography was used to evaluate the temporal change of cardiac neural regulation. The experimental group consisted of 23 subjects exposed to hyperbaric oxygen therapy of 202.65 kPa for 90 min every Monday to Friday for 4 weeks (20 treatments). The control group consisted of 15 age-, sex- and disease-matched subjects who were not exposed to hyperbaric therapy. Patients with medical complications and failure of wound healing were excluded to eliminate possible confounding effects. Results: There was no significant difference in baseline R-R interval (RR), variance, high-frequency power (HF), low-frequency power (LF), and LF/HF ratio between the two groups. In the hyperbaric oxygen group there were significant increases in changes of RR (82.7 ± 16.02 ms); variance 0.88 ± 0.12 ln(ms2); HF 1.06 ± 0.18 ln(ms2); and LF 0.87 ± 0.15 ln(ms2) after the treatment. Measurements of tissue oxygen demonstrated significant increases in local tissue oxygenation in the hyperbaric oxygen group (53.0 ± 2.6 mmHg) compared with the control group (27.5 ± 3.1 mmHg), P < 0.05. Conclusion: Hyperbaric oxygen therapy has a significant vagotonic effect, which is beneficial in improving cardiac neural regulation in patients with diabetic autonomic dysfunction.

KW - Autonomic neuropathy

KW - Clinical studies

KW - Diabetic foot

KW - Heart-rate monitoring

KW - Microvascular disease

UR - http://www.scopus.com/inward/record.url?scp=33645351694&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645351694&partnerID=8YFLogxK

U2 - 10.1111/j.1464-5491.2006.01798.x

DO - 10.1111/j.1464-5491.2006.01798.x

M3 - Article

VL - 23

SP - 360

EP - 366

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 4

ER -