Effect of hydroxypropyl-β-cyclodextrin on the solubility, photostability and in-vitro permeability of alkannin/shikonin enantiomers

Chau Yang Chen, Fu An Chen, Wu An-Bang, Hsing Chu Hsu, Jaw Jou Kang, Hui Wen Cheng

Research output: Contribution to journalArticle

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Abstract

The influence of hydroxypropyl-β-cyclodextrin (HPCD) on the solubility, photostability, and the in-vitro permeability of alkannin/shikonin enantiomers (A/S) was investigated. Solubility of A/S increased approximately 200 fold at 50% HPCD. The phase-solubility diagram revealed the formation of a 1:1 inclusion complex of A/S-HPCD and a stability constant (k(s)) of 260.5 M -1. Addition of HPCD significantly decreased the photochemical decomposition rate of A/S at pH 9.0. The apparent-first-order photochemical decomposition rate constants of free and complexed A/S were calculated from the Lineweaver-Burk plot to be 0.329 and 0.156 h -1, respectively. The in-vitro permeability study showed that the release of A/S from four test bases followed a Higuchi release model. The presence of HPCD enhanced the A/S release rate by 34 and 54 fold in cream and gel form, respectively, at one-tenth A/S concentration of the control preparation-Shiunko ointment.

Original languageEnglish
Pages (from-to)171-178
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume141
Issue number1-2
DOIs
Publication statusPublished - Sep 6 1996

Fingerprint

Cyclodextrins
Solubility
Permeability
alkannin
In Vitro Techniques
shikonin
Ointments
Gels

Keywords

  • Alkannin/shikonin enantiomers
  • Hydroxypropyl-β-cyclodextrin
  • Permeability
  • Photostability
  • Solubility

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Effect of hydroxypropyl-β-cyclodextrin on the solubility, photostability and in-vitro permeability of alkannin/shikonin enantiomers. / Chen, Chau Yang; Chen, Fu An; An-Bang, Wu; Hsu, Hsing Chu; Kang, Jaw Jou; Cheng, Hui Wen.

In: International Journal of Pharmaceutics, Vol. 141, No. 1-2, 06.09.1996, p. 171-178.

Research output: Contribution to journalArticle

Chen, Chau Yang ; Chen, Fu An ; An-Bang, Wu ; Hsu, Hsing Chu ; Kang, Jaw Jou ; Cheng, Hui Wen. / Effect of hydroxypropyl-β-cyclodextrin on the solubility, photostability and in-vitro permeability of alkannin/shikonin enantiomers. In: International Journal of Pharmaceutics. 1996 ; Vol. 141, No. 1-2. pp. 171-178.
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