Effect of glutaraldehyde on the humoral immunogenicity and structure of porcine dermal collagen membranes

King Jean Wu, Cheng Y. Wang, Hsein K. Lu

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Objectives: Our previous studies showed that the biodegradation rate of cross-linked porcine dermal collagen membrane (PDCM) could be retarded without changing its biocompatible character. The purpose of this study was to assay the humoral immune response of PDCM reconstitute with glutaraldehyde (GA) and observe their surface architectures. Methods: PDCM reconstituted with GA (0, 0.01, 0.05, and 3%) was implanted in 30 Sprague-Dawley rats. Sample sera were collected 3, 6, and 9 weeks after surgery and assayed with ELISA. The architectures of PDCMs were observed under SEM (100×). Results: The study showed that non cross-linked PDCM induced the highest immune response than any other cross-linked PDCMs (by optical density (OD) values, P

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalArchives of Oral Biology
Volume49
Issue number4
DOIs
Publication statusPublished - Apr 2004

Keywords

  • ELISA
  • Glutaraldehyde crosslinking
  • Immunogenicity
  • PDCM

ASJC Scopus subject areas

  • Dentistry(all)

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