Effect of Ginkgo biloba Extract (EGb-761) on Recovery of Erectile Dysfunction in Bilateral Cavernous Nerve Injury Rat Model

Yi No Wu, Chun Hou Liao, Kuo Chiang Chen, Shih Ping Liu, Han-Sun Chiang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective To investigate whether the therapeutic effect of Ginkgo biloba extract (GBE) in a rat model can improve erectile dysfunction after bilateral cavernous nerve injury. Methods Forty-three male Sprague-Dawley rats underwent cavernous nerve crush injury and were randomized into 4 groups, including: vehicle only, high-dose GBE, medium-dose GBE, and low-dose GBE. Eight animals underwent sham operation. Four weeks later, erectile function was assessed by cavernous nerve electrostimulation, and penile tissue was collected for histologic analysis. Results Significant recovery of erectile function was observed in the high-dose GBE group in a dose-dependent manner as compared with the vehicle-only group (P

Original languageEnglish
Article number19053
Pages (from-to)1214.e7-1214.e15
JournalUrology
Volume85
Issue number5
DOIs
Publication statusPublished - May 1 2015

ASJC Scopus subject areas

  • Urology

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