Abstract
Background: Estrogen has an antioxidant potential which may contribute to its cardioprotective effect. We sought to determine whether estrogen administration can affect coronary vasomotor tone in patients after angioplasty by reducing 8-iso-prostaglandin (PG) F2α concentrations, a bioactive product of lipid peroxidation. Methods: The study was designed to prospectively investigate 30 consecutive patients scheduled for elective coronary angioplasty. Patients were randomized into two groups according to whether they did not (group 1, n=15) or did have (group 2, n=15) intracoronary (i.c.) treatment with estrogen prior to coronary angioplasty. Results: There were no significant differences of collateral circulation assessed by intracoronary Doppler flow velocity during balloon inflations between the study groups. The diameters of the coronary artery at the dilated and distal segments were significantly reduced 15 min after dilation compared with those immediately after dilation in group 1 (both P2α levels in plasma from the coronary sinus rose significantly from 194±45 to 390±97 pg/ml (P2α levels in group 1 (r=0.73, P=0.002). Conclusions: 8-iso-PGF2α is released into the coronary circulation during angioplasty, and this vasoactive substance may contribute to the occurrence of vasoconstriction. Estrogen administration attenuated vasoconstriction by reducing the 8-iso-PGF2α levels. This finding may provide a new strategy to treat coronary vasoconstriction after angioplasty.
| Original language | English |
|---|---|
| Pages (from-to) | 465-472 |
| Number of pages | 8 |
| Journal | International Journal of Cardiology |
| Volume | 101 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 8 2005 |
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Keywords
- 8-iso-PGF
- Coronary angioplasty
- Estrogen
- Vasoconstriction
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Effect of estrogen on coronary vasoconstriction in patients undergoing coronary angioplasty. / Lee, Tsung-Ming; Chou, Tsai Fwu; Tsai, Chang Her.
In: International Journal of Cardiology, Vol. 101, No. 3, 08.06.2005, p. 465-472.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of estrogen on coronary vasoconstriction in patients undergoing coronary angioplasty
AU - Lee, Tsung-Ming
AU - Chou, Tsai Fwu
AU - Tsai, Chang Her
PY - 2005/6/8
Y1 - 2005/6/8
N2 - Background: Estrogen has an antioxidant potential which may contribute to its cardioprotective effect. We sought to determine whether estrogen administration can affect coronary vasomotor tone in patients after angioplasty by reducing 8-iso-prostaglandin (PG) F2α concentrations, a bioactive product of lipid peroxidation. Methods: The study was designed to prospectively investigate 30 consecutive patients scheduled for elective coronary angioplasty. Patients were randomized into two groups according to whether they did not (group 1, n=15) or did have (group 2, n=15) intracoronary (i.c.) treatment with estrogen prior to coronary angioplasty. Results: There were no significant differences of collateral circulation assessed by intracoronary Doppler flow velocity during balloon inflations between the study groups. The diameters of the coronary artery at the dilated and distal segments were significantly reduced 15 min after dilation compared with those immediately after dilation in group 1 (both P2α levels in plasma from the coronary sinus rose significantly from 194±45 to 390±97 pg/ml (P2α levels in group 1 (r=0.73, P=0.002). Conclusions: 8-iso-PGF2α is released into the coronary circulation during angioplasty, and this vasoactive substance may contribute to the occurrence of vasoconstriction. Estrogen administration attenuated vasoconstriction by reducing the 8-iso-PGF2α levels. This finding may provide a new strategy to treat coronary vasoconstriction after angioplasty.
AB - Background: Estrogen has an antioxidant potential which may contribute to its cardioprotective effect. We sought to determine whether estrogen administration can affect coronary vasomotor tone in patients after angioplasty by reducing 8-iso-prostaglandin (PG) F2α concentrations, a bioactive product of lipid peroxidation. Methods: The study was designed to prospectively investigate 30 consecutive patients scheduled for elective coronary angioplasty. Patients were randomized into two groups according to whether they did not (group 1, n=15) or did have (group 2, n=15) intracoronary (i.c.) treatment with estrogen prior to coronary angioplasty. Results: There were no significant differences of collateral circulation assessed by intracoronary Doppler flow velocity during balloon inflations between the study groups. The diameters of the coronary artery at the dilated and distal segments were significantly reduced 15 min after dilation compared with those immediately after dilation in group 1 (both P2α levels in plasma from the coronary sinus rose significantly from 194±45 to 390±97 pg/ml (P2α levels in group 1 (r=0.73, P=0.002). Conclusions: 8-iso-PGF2α is released into the coronary circulation during angioplasty, and this vasoactive substance may contribute to the occurrence of vasoconstriction. Estrogen administration attenuated vasoconstriction by reducing the 8-iso-PGF2α levels. This finding may provide a new strategy to treat coronary vasoconstriction after angioplasty.
KW - 8-iso-PGF
KW - Coronary angioplasty
KW - Estrogen
KW - Vasoconstriction
UR - http://www.scopus.com/inward/record.url?scp=19344362083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=19344362083&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2004.05.044
DO - 10.1016/j.ijcard.2004.05.044
M3 - Article
C2 - 15907416
AN - SCOPUS:19344362083
VL - 101
SP - 465
EP - 472
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -