Effect of esmolol on positive-pressure ventilation-induced variations of arterial pressure in anaesthetized humans

Hsien Yong Lai, Cheryl C.H. Yang, Ching Feng Cheng, Fan Yen Huang, Yi Lee, Ming Hwang Shyr, Terry B.J. Kuo

Research output: Contribution to journalArticle

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Abstract

Positive-pressure ventilation-induced variations in arterial pressure have been related to cardiac sympathetic activity in animals. However, the effect of β-adrenoceptor blockade on these variations in anaesthetized humans under positive-pressure ventilation has not yet been investigated. In the present study, RAPV (respiratory-related arterial pressure variability) and %SPV (percentile systolic pressure variation) were determined before and after esmolol treatment in ten mechanically ventilated patients. RAPV and %SPV decreased significantly after intravenous esmolol (I mg/kg of body weight) treatment (maximal decrease of RAPV, 50% and %SPV, 35%). Linear regression analysis of RAPV and %SPV before and after esmolol treatment both revealed high correlation (r = 0.93 and 0.91 respectively). The amplitudes of RAPV and %SPV also significantly increased in a graded way with higher tidal volumes. Thus we propose that esmolol suppresses the variations in arterial pressure induced by positive-pressure mechanical ventilation, and we suggest that RAPV and %SPV may be alternative choices for monitoring cardiac sympathetic regulation in anaesthetized patients under positive-pressure ventilation.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalClinical Science
Volume107
Issue number3
DOIs
Publication statusPublished - Sep 2004
Externally publishedYes

Fingerprint

Positive-Pressure Respiration
Arterial Pressure
esmolol
Tidal Volume
Artificial Respiration
Adrenergic Receptors
Linear Models
Therapeutics
Body Weight
Regression Analysis
Blood Pressure

Keywords

  • Adrenergic receptor
  • Arterial pressure
  • Autonomic nervous system
  • Positive-pressure ventilation
  • Systolic pressure

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effect of esmolol on positive-pressure ventilation-induced variations of arterial pressure in anaesthetized humans. / Lai, Hsien Yong; Yang, Cheryl C.H.; Cheng, Ching Feng; Huang, Fan Yen; Lee, Yi; Shyr, Ming Hwang; Kuo, Terry B.J.

In: Clinical Science, Vol. 107, No. 3, 09.2004, p. 303-308.

Research output: Contribution to journalArticle

Lai, Hsien Yong ; Yang, Cheryl C.H. ; Cheng, Ching Feng ; Huang, Fan Yen ; Lee, Yi ; Shyr, Ming Hwang ; Kuo, Terry B.J. / Effect of esmolol on positive-pressure ventilation-induced variations of arterial pressure in anaesthetized humans. In: Clinical Science. 2004 ; Vol. 107, No. 3. pp. 303-308.
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