Effect of emodin on cooked-food mutagen activation

H. Lee, S. J. Tsai

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The herbs Rheum palmatum B and Polygonum cuspidatum S are frequently used as laxatives and anticancer drugs in Chinese medicine. The antimutagenic activity of these herbs as well as their active component emodin was examined in Salmonella typhimurium TA98. The crude extracts and emodin induced a dose-dependent decrease in the mutagenicity of benzo[a]pyrene (B[a]P), 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2). Furthermore, emodin reduced the mutagenicity of IQ by direct inhibition of the hepatic microsomal activation and not by interaction with proximate metabolites of IQ and/or by modification of DNA repair processes in the bacterial cell.

Original languageEnglish
Pages (from-to)765-770
Number of pages6
JournalFood and Chemical Toxicology
Volume29
Issue number11
DOIs
Publication statusPublished - 1991
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this