Effect of emodin on cooked-food mutagen activation

H. Lee, S. J. Tsai

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The herbs Rheum palmatum B and Polygonum cuspidatum S are frequently used as laxatives and anticancer drugs in Chinese medicine. The antimutagenic activity of these herbs as well as their active component emodin was examined in Salmonella typhimurium TA98. The crude extracts and emodin induced a dose-dependent decrease in the mutagenicity of benzo[a]pyrene (B[a]P), 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2). Furthermore, emodin reduced the mutagenicity of IQ by direct inhibition of the hepatic microsomal activation and not by interaction with proximate metabolites of IQ and/or by modification of DNA repair processes in the bacterial cell.

Original languageEnglish
Pages (from-to)765-770
Number of pages6
JournalFood and Chemical Toxicology
Volume29
Issue number11
DOIs
Publication statusPublished - 1991
Externally publishedYes

Fingerprint

Emodin
emodin
cooked foods
Mutagens
mutagenicity
Chemical activation
Food
herbs
Fallopia japonica
Rheum palmatum
Bacterial Physiological Phenomena
Rheum
Reynoutria japonica
quinoline
laxatives
antimutagenic activity
Laxatives
Salmonella
antineoplastic agents
Benzo(a)pyrene

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Effect of emodin on cooked-food mutagen activation. / Lee, H.; Tsai, S. J.

In: Food and Chemical Toxicology, Vol. 29, No. 11, 1991, p. 765-770.

Research output: Contribution to journalArticle

Lee, H. ; Tsai, S. J. / Effect of emodin on cooked-food mutagen activation. In: Food and Chemical Toxicology. 1991 ; Vol. 29, No. 11. pp. 765-770.
@article{4a0c6668e097453db33b2fa6be34852e,
title = "Effect of emodin on cooked-food mutagen activation",
abstract = "The herbs Rheum palmatum B and Polygonum cuspidatum S are frequently used as laxatives and anticancer drugs in Chinese medicine. The antimutagenic activity of these herbs as well as their active component emodin was examined in Salmonella typhimurium TA98. The crude extracts and emodin induced a dose-dependent decrease in the mutagenicity of benzo[a]pyrene (B[a]P), 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2). Furthermore, emodin reduced the mutagenicity of IQ by direct inhibition of the hepatic microsomal activation and not by interaction with proximate metabolites of IQ and/or by modification of DNA repair processes in the bacterial cell.",
author = "H. Lee and Tsai, {S. J.}",
year = "1991",
doi = "10.1016/0278-6915(91)90185-A",
language = "English",
volume = "29",
pages = "765--770",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - Effect of emodin on cooked-food mutagen activation

AU - Lee, H.

AU - Tsai, S. J.

PY - 1991

Y1 - 1991

N2 - The herbs Rheum palmatum B and Polygonum cuspidatum S are frequently used as laxatives and anticancer drugs in Chinese medicine. The antimutagenic activity of these herbs as well as their active component emodin was examined in Salmonella typhimurium TA98. The crude extracts and emodin induced a dose-dependent decrease in the mutagenicity of benzo[a]pyrene (B[a]P), 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2). Furthermore, emodin reduced the mutagenicity of IQ by direct inhibition of the hepatic microsomal activation and not by interaction with proximate metabolites of IQ and/or by modification of DNA repair processes in the bacterial cell.

AB - The herbs Rheum palmatum B and Polygonum cuspidatum S are frequently used as laxatives and anticancer drugs in Chinese medicine. The antimutagenic activity of these herbs as well as their active component emodin was examined in Salmonella typhimurium TA98. The crude extracts and emodin induced a dose-dependent decrease in the mutagenicity of benzo[a]pyrene (B[a]P), 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2). Furthermore, emodin reduced the mutagenicity of IQ by direct inhibition of the hepatic microsomal activation and not by interaction with proximate metabolites of IQ and/or by modification of DNA repair processes in the bacterial cell.

UR - http://www.scopus.com/inward/record.url?scp=0026354089&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026354089&partnerID=8YFLogxK

U2 - 10.1016/0278-6915(91)90185-A

DO - 10.1016/0278-6915(91)90185-A

M3 - Article

C2 - 1761256

AN - SCOPUS:0026354089

VL - 29

SP - 765

EP - 770

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

IS - 11

ER -