Effect of early percutaneous coronary intervention on one-year risk of pneumonia and pneumonia-related adverse outcomes in patients with acute myocardial infarction

Chao Feng Lin, Ya Hui Chang, Nai Fang Chi, Ming Tsang Chuang, Li Nien Chien

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Aims: The aim of this study was to investigate the association between early percutaneous coronary intervention (PCI) and pneumonia risk in patients with acute myocardial infarction (AMI) by using Taiwan's National Health Insurance Research Database (NHIRD). Methods and results: In total, 4,732 patients with non-ST-elevation myocardial infarction (NSTEMI) and 5,465 with ST-elevation myocardial infarction (STEMI) who had received PCI during AMI hospitalisation (early PCI) were evaluated. Patients who did not receive PCI during AMI hospitalisation (deferred PCI) were matched through propensity score matching. The incidence rates (per 100 person-months) of pneumonia hospitalisation, pneumonia-related respiratory failure, and pneumonia-related death associated with early PCI in patients with NSTEMI were 0.36 (95% confidence interval [CI]: 0.32-0.42), 0.12 (95% CI: 0.10-0.16), and 0.08 (95% CI: 0.06-0.11), respectively. In patients with STEMI, the incidence rates (per 100 person-months) of the aforementioned adverse events were 0.16 (95% CI: 0.13-0.20), 0.04 (95% CI: 0.03-0.06), and 0.02 (95% CI: 0.01-0.04), respectively. After adjustment for patients' clinical variables, early PCI was associated with reduced risks of pneumonia hospitalisation (adjusted hazard ratio [aHR] 0.54, 95% CI: 0.43-0.68, p<0.001), pneumonia-related respiratory failure (aHR 0.54, 95% CI: 0.35-0.84, p=0.006), and pneumonia-related death (aHR 0.29, 95% CI: 0.17-0.52, p<0.001) in patients with NSTEMI. In patients with STEMI, early PCI was beneficial for pneumonia hospitalisation (aHR 0.62, 95% CI: 0.45-0.86, p=0.004). Conclusions: Early PCI might reduce the risk of pneumonia hospitalisation in patients with AMI.

Original languageEnglish
Pages (from-to)1705-1713
Number of pages9
JournalEuroIntervention
Volume13
Issue number14
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

Percutaneous Coronary Intervention
Pneumonia
Myocardial Infarction
Confidence Intervals
Hospitalization
Respiratory Insufficiency
Propensity Score
Incidence
National Health Programs
Taiwan
Databases

Keywords

  • Clinical research
  • Non-ST-elevation myocardial infarction (NSTEMI)
  • ST-elevation myocardial infarction (STEMI)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Effect of early percutaneous coronary intervention on one-year risk of pneumonia and pneumonia-related adverse outcomes in patients with acute myocardial infarction. / Lin, Chao Feng; Chang, Ya Hui; Chi, Nai Fang; Chuang, Ming Tsang; Chien, Li Nien.

In: EuroIntervention, Vol. 13, No. 14, 01.02.2018, p. 1705-1713.

Research output: Contribution to journalArticle

@article{cf9c6188e32b49e59c4e43a5bc95fa63,
title = "Effect of early percutaneous coronary intervention on one-year risk of pneumonia and pneumonia-related adverse outcomes in patients with acute myocardial infarction",
abstract = "Aims: The aim of this study was to investigate the association between early percutaneous coronary intervention (PCI) and pneumonia risk in patients with acute myocardial infarction (AMI) by using Taiwan's National Health Insurance Research Database (NHIRD). Methods and results: In total, 4,732 patients with non-ST-elevation myocardial infarction (NSTEMI) and 5,465 with ST-elevation myocardial infarction (STEMI) who had received PCI during AMI hospitalisation (early PCI) were evaluated. Patients who did not receive PCI during AMI hospitalisation (deferred PCI) were matched through propensity score matching. The incidence rates (per 100 person-months) of pneumonia hospitalisation, pneumonia-related respiratory failure, and pneumonia-related death associated with early PCI in patients with NSTEMI were 0.36 (95{\%} confidence interval [CI]: 0.32-0.42), 0.12 (95{\%} CI: 0.10-0.16), and 0.08 (95{\%} CI: 0.06-0.11), respectively. In patients with STEMI, the incidence rates (per 100 person-months) of the aforementioned adverse events were 0.16 (95{\%} CI: 0.13-0.20), 0.04 (95{\%} CI: 0.03-0.06), and 0.02 (95{\%} CI: 0.01-0.04), respectively. After adjustment for patients' clinical variables, early PCI was associated with reduced risks of pneumonia hospitalisation (adjusted hazard ratio [aHR] 0.54, 95{\%} CI: 0.43-0.68, p<0.001), pneumonia-related respiratory failure (aHR 0.54, 95{\%} CI: 0.35-0.84, p=0.006), and pneumonia-related death (aHR 0.29, 95{\%} CI: 0.17-0.52, p<0.001) in patients with NSTEMI. In patients with STEMI, early PCI was beneficial for pneumonia hospitalisation (aHR 0.62, 95{\%} CI: 0.45-0.86, p=0.004). Conclusions: Early PCI might reduce the risk of pneumonia hospitalisation in patients with AMI.",
keywords = "Clinical research, Non-ST-elevation myocardial infarction (NSTEMI), ST-elevation myocardial infarction (STEMI)",
author = "Lin, {Chao Feng} and Chang, {Ya Hui} and Chi, {Nai Fang} and Chuang, {Ming Tsang} and Chien, {Li Nien}",
year = "2018",
month = "2",
day = "1",
doi = "10.4244/EIJ-D-16-00840",
language = "English",
volume = "13",
pages = "1705--1713",
journal = "EuroIntervention",
issn = "1774-024X",
publisher = "EuroPCR",
number = "14",

}

TY - JOUR

T1 - Effect of early percutaneous coronary intervention on one-year risk of pneumonia and pneumonia-related adverse outcomes in patients with acute myocardial infarction

AU - Lin, Chao Feng

AU - Chang, Ya Hui

AU - Chi, Nai Fang

AU - Chuang, Ming Tsang

AU - Chien, Li Nien

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Aims: The aim of this study was to investigate the association between early percutaneous coronary intervention (PCI) and pneumonia risk in patients with acute myocardial infarction (AMI) by using Taiwan's National Health Insurance Research Database (NHIRD). Methods and results: In total, 4,732 patients with non-ST-elevation myocardial infarction (NSTEMI) and 5,465 with ST-elevation myocardial infarction (STEMI) who had received PCI during AMI hospitalisation (early PCI) were evaluated. Patients who did not receive PCI during AMI hospitalisation (deferred PCI) were matched through propensity score matching. The incidence rates (per 100 person-months) of pneumonia hospitalisation, pneumonia-related respiratory failure, and pneumonia-related death associated with early PCI in patients with NSTEMI were 0.36 (95% confidence interval [CI]: 0.32-0.42), 0.12 (95% CI: 0.10-0.16), and 0.08 (95% CI: 0.06-0.11), respectively. In patients with STEMI, the incidence rates (per 100 person-months) of the aforementioned adverse events were 0.16 (95% CI: 0.13-0.20), 0.04 (95% CI: 0.03-0.06), and 0.02 (95% CI: 0.01-0.04), respectively. After adjustment for patients' clinical variables, early PCI was associated with reduced risks of pneumonia hospitalisation (adjusted hazard ratio [aHR] 0.54, 95% CI: 0.43-0.68, p<0.001), pneumonia-related respiratory failure (aHR 0.54, 95% CI: 0.35-0.84, p=0.006), and pneumonia-related death (aHR 0.29, 95% CI: 0.17-0.52, p<0.001) in patients with NSTEMI. In patients with STEMI, early PCI was beneficial for pneumonia hospitalisation (aHR 0.62, 95% CI: 0.45-0.86, p=0.004). Conclusions: Early PCI might reduce the risk of pneumonia hospitalisation in patients with AMI.

AB - Aims: The aim of this study was to investigate the association between early percutaneous coronary intervention (PCI) and pneumonia risk in patients with acute myocardial infarction (AMI) by using Taiwan's National Health Insurance Research Database (NHIRD). Methods and results: In total, 4,732 patients with non-ST-elevation myocardial infarction (NSTEMI) and 5,465 with ST-elevation myocardial infarction (STEMI) who had received PCI during AMI hospitalisation (early PCI) were evaluated. Patients who did not receive PCI during AMI hospitalisation (deferred PCI) were matched through propensity score matching. The incidence rates (per 100 person-months) of pneumonia hospitalisation, pneumonia-related respiratory failure, and pneumonia-related death associated with early PCI in patients with NSTEMI were 0.36 (95% confidence interval [CI]: 0.32-0.42), 0.12 (95% CI: 0.10-0.16), and 0.08 (95% CI: 0.06-0.11), respectively. In patients with STEMI, the incidence rates (per 100 person-months) of the aforementioned adverse events were 0.16 (95% CI: 0.13-0.20), 0.04 (95% CI: 0.03-0.06), and 0.02 (95% CI: 0.01-0.04), respectively. After adjustment for patients' clinical variables, early PCI was associated with reduced risks of pneumonia hospitalisation (adjusted hazard ratio [aHR] 0.54, 95% CI: 0.43-0.68, p<0.001), pneumonia-related respiratory failure (aHR 0.54, 95% CI: 0.35-0.84, p=0.006), and pneumonia-related death (aHR 0.29, 95% CI: 0.17-0.52, p<0.001) in patients with NSTEMI. In patients with STEMI, early PCI was beneficial for pneumonia hospitalisation (aHR 0.62, 95% CI: 0.45-0.86, p=0.004). Conclusions: Early PCI might reduce the risk of pneumonia hospitalisation in patients with AMI.

KW - Clinical research

KW - Non-ST-elevation myocardial infarction (NSTEMI)

KW - ST-elevation myocardial infarction (STEMI)

UR - http://www.scopus.com/inward/record.url?scp=85044072509&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85044072509&partnerID=8YFLogxK

U2 - 10.4244/EIJ-D-16-00840

DO - 10.4244/EIJ-D-16-00840

M3 - Article

AN - SCOPUS:85044072509

VL - 13

SP - 1705

EP - 1713

JO - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

IS - 14

ER -