Effect of dietary casein and soy protein on plasma lipids in a streptozotocin-induced diabetes model in hamsters

Sung Ling Yeh, Chang Y. Hsu, Ming-Che Hsieh

Research output: Contribution to journalArticle

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Abstract

While it is known that soy protein diet depresses serum cholesterol relative to a casein diet in hypercholesterolemic humans and a variety of animal species, the effect of soy protein on diabetes mellitus-induced hyperlipidemia has not been studied. We investigated the effect of soy protein and casein on the levels of plasma glucose and lipids in hamsters with streptozotocin-induced diabetes. Thirty-one hamsters were divided into control and diabetic groups. Diabetes was induced by introperitoneal injection of streptozotocin. Control and diabetic hamsters were further assigned to two subgroups, respectively. One subgroup was fed with casein and the other with soy protein isolate. The basal composition of the diets was identical, except for the difference in protein source. After 4 weeks of the test diet, plasma concentrations of glucose, triglyceride (TG), and nonesterified fatty acids (NEFA) were significantly higher in diabetic groups than in the control groups. The plasma levels of glucose, TG, and total cholesterol were significantly lower in the diabetic soy protein group than in the diabetic casein group. The plasma total cholesterol level in the diabetic soy protein group was similar to those of the control subgroups. No significant differences in plasma glucose, TG, cholesterol or NEFA concentrations were observed between the two control subgroups. The malondialdehyde level in the livers, as well as the erythrocyte glutathione peroxidase and superoxide dismutase activities did not differ between control and diabetic groups, nor were there differences between the casein and soy protein groups. These findings suggest that soy protein also exerts hypocholesterolemic effects in this diabetic model system, and had favorable effects on lowering plasma glucose and TG. The soy protein diet did not affect lipid peroxide production or the erythrocyte antioxidant enzyme activities indicated that the antioxidant system was not changed under the present experimental condition.

Original languageEnglish
Pages (from-to)1757-1768
Number of pages12
JournalNutrition Research
Volume18
Issue number10
DOIs
Publication statusPublished - Oct 1998

Fingerprint

Soybean Proteins
Experimental Diabetes Mellitus
Dietary Proteins
Caseins
Cricetinae
Lipids
Diet
Triglycerides
Glucose
Cholesterol
Nonesterified Fatty Acids
Control Groups
Antioxidants
Erythrocytes
Lipid Peroxides
Streptozocin
Glutathione Peroxidase
Hyperlipidemias
Malondialdehyde
Superoxide Dismutase

Keywords

  • Casein
  • Diabetes
  • Hamster
  • Hypercholesterolemia
  • Soy protein

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Effect of dietary casein and soy protein on plasma lipids in a streptozotocin-induced diabetes model in hamsters. / Yeh, Sung Ling; Hsu, Chang Y.; Hsieh, Ming-Che.

In: Nutrition Research, Vol. 18, No. 10, 10.1998, p. 1757-1768.

Research output: Contribution to journalArticle

Yeh, Sung Ling ; Hsu, Chang Y. ; Hsieh, Ming-Che. / Effect of dietary casein and soy protein on plasma lipids in a streptozotocin-induced diabetes model in hamsters. In: Nutrition Research. 1998 ; Vol. 18, No. 10. pp. 1757-1768.
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