Effect of curcumin supplementation on physiological fatigue and physical performance in mice

Wen Ching Huang, Wan Chun Chiu, Hsiao Li Chuang, Deh Wei Tang, Zon Min Lee, Wei Li, Fu An Chen, Chi Chang Huang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180 μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

Original languageEnglish
Pages (from-to)905-921
Number of pages17
JournalNutrients
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 30 2015

Fingerprint

Curcumin
curcumin
Fatigue
mice
exercise
Blood Urea Nitrogen
Hand Strength
creatine kinase
Creatine Kinase
Aspartate Aminotransferases
urea nitrogen
Alanine Transaminase
alanine transaminase
Ammonia
aspartate transaminase
lactates
Lactic Acid
ammonia
Curcuma
Spices

Keywords

  • Ammonia
  • Anti-fatigue
  • Blood urea nitrogen
  • Creatine kinase
  • Endurance
  • Forelimb grip strength
  • Lactate

ASJC Scopus subject areas

  • Food Science

Cite this

Huang, W. C., Chiu, W. C., Chuang, H. L., Tang, D. W., Lee, Z. M., Li, W., ... Huang, C. C. (2015). Effect of curcumin supplementation on physiological fatigue and physical performance in mice. Nutrients, 7(2), 905-921. https://doi.org/10.3390/nu7020905

Effect of curcumin supplementation on physiological fatigue and physical performance in mice. / Huang, Wen Ching; Chiu, Wan Chun; Chuang, Hsiao Li; Tang, Deh Wei; Lee, Zon Min; Li, Wei; Chen, Fu An; Huang, Chi Chang.

In: Nutrients, Vol. 7, No. 2, 30.01.2015, p. 905-921.

Research output: Contribution to journalArticle

Huang, WC, Chiu, WC, Chuang, HL, Tang, DW, Lee, ZM, Li, W, Chen, FA & Huang, CC 2015, 'Effect of curcumin supplementation on physiological fatigue and physical performance in mice', Nutrients, vol. 7, no. 2, pp. 905-921. https://doi.org/10.3390/nu7020905
Huang, Wen Ching ; Chiu, Wan Chun ; Chuang, Hsiao Li ; Tang, Deh Wei ; Lee, Zon Min ; Li, Wei ; Chen, Fu An ; Huang, Chi Chang. / Effect of curcumin supplementation on physiological fatigue and physical performance in mice. In: Nutrients. 2015 ; Vol. 7, No. 2. pp. 905-921.
@article{c3339aecaa504f8394343379a6c28070,
title = "Effect of curcumin supplementation on physiological fatigue and physical performance in mice",
abstract = "Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180 μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.",
keywords = "Ammonia, Anti-fatigue, Blood urea nitrogen, Creatine kinase, Endurance, Forelimb grip strength, Lactate",
author = "Huang, {Wen Ching} and Chiu, {Wan Chun} and Chuang, {Hsiao Li} and Tang, {Deh Wei} and Lee, {Zon Min} and Wei Li and Chen, {Fu An} and Huang, {Chi Chang}",
year = "2015",
month = "1",
day = "30",
doi = "10.3390/nu7020905",
language = "English",
volume = "7",
pages = "905--921",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

TY - JOUR

T1 - Effect of curcumin supplementation on physiological fatigue and physical performance in mice

AU - Huang, Wen Ching

AU - Chiu, Wan Chun

AU - Chuang, Hsiao Li

AU - Tang, Deh Wei

AU - Lee, Zon Min

AU - Li, Wei

AU - Chen, Fu An

AU - Huang, Chi Chang

PY - 2015/1/30

Y1 - 2015/1/30

N2 - Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180 μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

AB - Curcumin (CCM) is a well-known phytocompound and food component found in the spice turmeric and has multifunctional bioactivities. However, few studies have examined its effects on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of CCM supplementation on fatigue and ergogenic function following physical challenge in mice. Male ICR mice were divided into four groups to receive vehicle or CCM (180 μg/mL) by oral gavage at 0, 12.3, 24.6, or 61.5 mL/kg/day for four weeks. Exercise performance and anti-fatigue function were evaluated after physical challenge by forelimb grip strength, exhaustive swimming time, and levels of physical fatigue-associated biomarkers serum lactate, ammonia, blood urea nitrogen (BUN), and glucose and tissue damage markers such as aspartate transaminase (AST), alanine transaminase (ALT), and creatine kinase (CK). CCM supplementation dose-dependently increased grip strength and endurance performance and significantly decreased lactate, ammonia, BUN, AST, ALT, and CK levels after physical challenge. Muscular glycogen content, an important energy source for exercise, was significantly increased. CCM supplementation had few subchronic toxic effects. CCM supplementation may have a wide spectrum of bioactivities for promoting health, improving exercise performance and preventing fatigue.

KW - Ammonia

KW - Anti-fatigue

KW - Blood urea nitrogen

KW - Creatine kinase

KW - Endurance

KW - Forelimb grip strength

KW - Lactate

UR - http://www.scopus.com/inward/record.url?scp=84961291322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84961291322&partnerID=8YFLogxK

U2 - 10.3390/nu7020905

DO - 10.3390/nu7020905

M3 - Article

VL - 7

SP - 905

EP - 921

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

ER -