Effect of coriolus versicolor mycelia extract on exercise performance and physical fatigue in mice

Chun Sheng Ho, Yu Tang Tung, Woon Man Kung, Wen Ching Huang, Wing Ki Leung, Chi Chang Huang, Jyh Horng Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study, Coriolus versicolor mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups (n = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity. Results revealed that the forelimb grip strength of mice in group CVM-1X, CVM-2X and CVM-5X were significantly increased by 1.20-, 1.18- and 1.23-fold, respectively, compared to the vehicle group. After the 15 minute swimming exercise, the levels of serum lactate of CVM-1X, CVM-2X and CVM-5X groups were significantly lower than the vehicle control group by 29%, 23% and 31%, respectively. The levels of ammonia in CVM-1X, CVM-2X and CVM-5X groups were significantly lowered by 22%, 25% and 41%, respectively, compared to the vehicle control group. In addition, the levels of serum CK in CVM-2X and CVM-5X groups were significantly lowered by 13% and 11%, respectively, compared to the vehicle control group. Accordingly, the supplementation with CVM has beneficial effects on performance improvement and anti-fatigue activity, and thus has great potential as a source for natural health products.

Original languageEnglish
Pages (from-to)1110-1117
Number of pages8
JournalInternational Journal of Medical Sciences
Volume14
Issue number11
DOIs
Publication statusPublished - Sep 4 2017

Keywords

  • Anti-fatigue
  • Coriolus versicolor
  • Exercise performance
  • Mycelia
  • Polysaccharopeptide

ASJC Scopus subject areas

  • Medicine(all)

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