TY - JOUR
T1 - Effect of coriolus versicolor mycelia extract on exercise performance and physical fatigue in mice
AU - Ho, Chun Sheng
AU - Tung, Yu Tang
AU - Kung, Woon Man
AU - Huang, Wen Ching
AU - Leung, Wing Ki
AU - Huang, Chi Chang
AU - Wu, Jyh Horng
N1 - Funding Information:
This research was supported by the Ministry of Science and Technology of Taiwan (grant no. MOST-104-2811-B-179-001 to Chi-Chang Huang) and an institutional grant to Chun-Sheng Ho (Lo-Hsu Foundation, Inc., Lotung Poh-Ai Hospital). The authors are grateful to Drs. Chien-Chao Chiu, Hsiao-Li Chuang and Chin-Shan Ho for technical assistance in animal experiments.
Publisher Copyright:
© Ivyspring International Publisher.
PY - 2017/9/4
Y1 - 2017/9/4
N2 - In this study, Coriolus versicolor mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups (n = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity. Results revealed that the forelimb grip strength of mice in group CVM-1X, CVM-2X and CVM-5X were significantly increased by 1.20-, 1.18- and 1.23-fold, respectively, compared to the vehicle group. After the 15 minute swimming exercise, the levels of serum lactate of CVM-1X, CVM-2X and CVM-5X groups were significantly lower than the vehicle control group by 29%, 23% and 31%, respectively. The levels of ammonia in CVM-1X, CVM-2X and CVM-5X groups were significantly lowered by 22%, 25% and 41%, respectively, compared to the vehicle control group. In addition, the levels of serum CK in CVM-2X and CVM-5X groups were significantly lowered by 13% and 11%, respectively, compared to the vehicle control group. Accordingly, the supplementation with CVM has beneficial effects on performance improvement and anti-fatigue activity, and thus has great potential as a source for natural health products.
AB - In this study, Coriolus versicolor mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups (n = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity. Results revealed that the forelimb grip strength of mice in group CVM-1X, CVM-2X and CVM-5X were significantly increased by 1.20-, 1.18- and 1.23-fold, respectively, compared to the vehicle group. After the 15 minute swimming exercise, the levels of serum lactate of CVM-1X, CVM-2X and CVM-5X groups were significantly lower than the vehicle control group by 29%, 23% and 31%, respectively. The levels of ammonia in CVM-1X, CVM-2X and CVM-5X groups were significantly lowered by 22%, 25% and 41%, respectively, compared to the vehicle control group. In addition, the levels of serum CK in CVM-2X and CVM-5X groups were significantly lowered by 13% and 11%, respectively, compared to the vehicle control group. Accordingly, the supplementation with CVM has beneficial effects on performance improvement and anti-fatigue activity, and thus has great potential as a source for natural health products.
KW - Anti-fatigue
KW - Coriolus versicolor
KW - Exercise performance
KW - Mycelia
KW - Polysaccharopeptide
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U2 - 10.7150/ijms.20547
DO - 10.7150/ijms.20547
M3 - Article
AN - SCOPUS:85029609836
SN - 1449-1907
VL - 14
SP - 1110
EP - 1117
JO - International Journal of Medical Sciences
JF - International Journal of Medical Sciences
IS - 11
ER -