Effect of Chinese herbal medicine on stroke patients with type 2 diabetes

Fuu Jen Tsai, Tsung Jung Ho, Chi Fung Cheng, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Ju Pi Li, Cheng Wen Lin, Jaung Geng Lin, Jung Chun Lin, Chih Chien Lin, Wen Miin Liang, Ying Ju Lin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Ethnopharmacological relevance Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and stroke by supplementing Qi and activating blood circulation. Aim of the study This study aimed to investigate the frequencies and patterns of CHM treatment for stroke patients with T2D and the outcomes of long-term use in Taiwan. Materials and methods We identified 3079 stroke patients (ICD-9-CM: 430–438) with T2D. We allocated 618 stroke patients, matched for age, gender, and T2D-to-stroke duration, to both CHM and non-CHM groups. Chi-square test, conditional multivariable logistic regression, Kaplan-Meier method, and the log-rank test were used in this study. Results The CHM group was characterized by more cases of chronic obstructive pulmonary disease, ulcer disease, hyperlipidemia, tobacco use, and higher income. The cumulative survival probability was higher in the CHM group (P<0.001, log rank test); after adjusting for comorbidities, income, and urbanization level, this group also exhibited a lower mortality hazard ratio (0.37, 95% confidence interval [0.25–0.55]). Shu-Jing-Huo-Xue-Tang, Xue-Fu-Zhu-Yu-Tang, and Du-Huo-Ji-Sheng-Tang; and Dan-Shen, Niu-Xi, and Yan-Hu-Suo represented the top three formulas and herbs, respectively. Conclusion The use of CHM as adjunctive therapy may improve the overall survival (OS) of stroke patients with T2D. The list of the comprehensive herbal medicines that they used might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments in stroke patients with T2D.

Original languageEnglish
Pages (from-to)31-44
Number of pages14
JournalJournal of Ethnopharmacology
Volume200
DOIs
Publication statusPublished - Mar 22 2017

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Herbal Medicine
Type 2 Diabetes Mellitus
Stroke
Salvia miltiorrhiza
Qi
Urbanization
Survival
Blood Circulation
Tobacco Use
International Classification of Diseases
Chi-Square Distribution
Therapeutics
Hyperlipidemias
Taiwan
Chronic Obstructive Pulmonary Disease
Ulcer
Comorbidity
China
Logistic Models
Confidence Intervals

Keywords

  • Chinese herbal medicine
  • Stroke
  • Type 2 diabetes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Tsai, F. J., Ho, T. J., Cheng, C. F., Liu, X., Tsang, H., Lin, T. H., ... Lin, Y. J. (2017). Effect of Chinese herbal medicine on stroke patients with type 2 diabetes. Journal of Ethnopharmacology, 200, 31-44. https://doi.org/10.1016/j.jep.2017.02.024

Effect of Chinese herbal medicine on stroke patients with type 2 diabetes. / Tsai, Fuu Jen; Ho, Tsung Jung; Cheng, Chi Fung; Liu, Xiang; Tsang, Hsinyi; Lin, Ting Hsu; Liao, Chiu Chu; Huang, Shao Mei; Li, Ju Pi; Lin, Cheng Wen; Lin, Jaung Geng; Lin, Jung Chun; Lin, Chih Chien; Liang, Wen Miin; Lin, Ying Ju.

In: Journal of Ethnopharmacology, Vol. 200, 22.03.2017, p. 31-44.

Research output: Contribution to journalArticle

Tsai, FJ, Ho, TJ, Cheng, CF, Liu, X, Tsang, H, Lin, TH, Liao, CC, Huang, SM, Li, JP, Lin, CW, Lin, JG, Lin, JC, Lin, CC, Liang, WM & Lin, YJ 2017, 'Effect of Chinese herbal medicine on stroke patients with type 2 diabetes', Journal of Ethnopharmacology, vol. 200, pp. 31-44. https://doi.org/10.1016/j.jep.2017.02.024
Tsai, Fuu Jen ; Ho, Tsung Jung ; Cheng, Chi Fung ; Liu, Xiang ; Tsang, Hsinyi ; Lin, Ting Hsu ; Liao, Chiu Chu ; Huang, Shao Mei ; Li, Ju Pi ; Lin, Cheng Wen ; Lin, Jaung Geng ; Lin, Jung Chun ; Lin, Chih Chien ; Liang, Wen Miin ; Lin, Ying Ju. / Effect of Chinese herbal medicine on stroke patients with type 2 diabetes. In: Journal of Ethnopharmacology. 2017 ; Vol. 200. pp. 31-44.
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abstract = "Ethnopharmacological relevance Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and stroke by supplementing Qi and activating blood circulation. Aim of the study This study aimed to investigate the frequencies and patterns of CHM treatment for stroke patients with T2D and the outcomes of long-term use in Taiwan. Materials and methods We identified 3079 stroke patients (ICD-9-CM: 430–438) with T2D. We allocated 618 stroke patients, matched for age, gender, and T2D-to-stroke duration, to both CHM and non-CHM groups. Chi-square test, conditional multivariable logistic regression, Kaplan-Meier method, and the log-rank test were used in this study. Results The CHM group was characterized by more cases of chronic obstructive pulmonary disease, ulcer disease, hyperlipidemia, tobacco use, and higher income. The cumulative survival probability was higher in the CHM group (P<0.001, log rank test); after adjusting for comorbidities, income, and urbanization level, this group also exhibited a lower mortality hazard ratio (0.37, 95{\%} confidence interval [0.25–0.55]). Shu-Jing-Huo-Xue-Tang, Xue-Fu-Zhu-Yu-Tang, and Du-Huo-Ji-Sheng-Tang; and Dan-Shen, Niu-Xi, and Yan-Hu-Suo represented the top three formulas and herbs, respectively. Conclusion The use of CHM as adjunctive therapy may improve the overall survival (OS) of stroke patients with T2D. The list of the comprehensive herbal medicines that they used might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments in stroke patients with T2D.",
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AU - Cheng, Chi Fung

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AU - Tsang, Hsinyi

AU - Lin, Ting Hsu

AU - Liao, Chiu Chu

AU - Huang, Shao Mei

AU - Li, Ju Pi

AU - Lin, Cheng Wen

AU - Lin, Jaung Geng

AU - Lin, Jung Chun

AU - Lin, Chih Chien

AU - Liang, Wen Miin

AU - Lin, Ying Ju

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N2 - Ethnopharmacological relevance Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and stroke by supplementing Qi and activating blood circulation. Aim of the study This study aimed to investigate the frequencies and patterns of CHM treatment for stroke patients with T2D and the outcomes of long-term use in Taiwan. Materials and methods We identified 3079 stroke patients (ICD-9-CM: 430–438) with T2D. We allocated 618 stroke patients, matched for age, gender, and T2D-to-stroke duration, to both CHM and non-CHM groups. Chi-square test, conditional multivariable logistic regression, Kaplan-Meier method, and the log-rank test were used in this study. Results The CHM group was characterized by more cases of chronic obstructive pulmonary disease, ulcer disease, hyperlipidemia, tobacco use, and higher income. The cumulative survival probability was higher in the CHM group (P<0.001, log rank test); after adjusting for comorbidities, income, and urbanization level, this group also exhibited a lower mortality hazard ratio (0.37, 95% confidence interval [0.25–0.55]). Shu-Jing-Huo-Xue-Tang, Xue-Fu-Zhu-Yu-Tang, and Du-Huo-Ji-Sheng-Tang; and Dan-Shen, Niu-Xi, and Yan-Hu-Suo represented the top three formulas and herbs, respectively. Conclusion The use of CHM as adjunctive therapy may improve the overall survival (OS) of stroke patients with T2D. The list of the comprehensive herbal medicines that they used might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments in stroke patients with T2D.

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