Effect of central glucagon infusion on macronutrient selection in rats

Naoko Komenami, Fu Hsiung Su, Louise Thibault

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Compared were the light-dark pattern of absolute energy intake and macronutrient selection of male Wistar rats intracerebroventricularly infused with glucagon (5 ng/h) or saline for 7 days in a three-way selection of macronutrients. Glucagon infusion induced a decrease in 24 h and nocturnal energy intake, whereas no significant change in kcal intake accompanied vehicle infusion. The decrease in kcal intake was due to a suppression of nocturnal ingestion of carbohydrate. This parameter was left unaffected with central vehicle infusion. Glucagon-infused rats had a significantly lower body weight gain than those infused with vehicle. Our study supports the hypothesis of central glucagon's suppressive effect on food intake, but reveals that the latter reflects a lower disposition to eat carbohydrate during the dark phase. The present work emphasizes the role of glucagon in the circadian regulation of carbohydrate intake.

Original languageEnglish
Pages (from-to)383-388
Number of pages6
JournalPhysiology and Behavior
Volume59
Issue number2
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Glucagon
Carbohydrates
Energy Intake
Eating
Weight Gain
Wistar Rats
Body Weight
Light

Keywords

  • Central glucagon infusion
  • Energy intake
  • Lateral ventricle
  • Macronutrient selection
  • Rats

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Physiology (medical)

Cite this

Effect of central glucagon infusion on macronutrient selection in rats. / Komenami, Naoko; Su, Fu Hsiung; Thibault, Louise.

In: Physiology and Behavior, Vol. 59, No. 2, 1996, p. 383-388.

Research output: Contribution to journalArticle

Komenami, Naoko ; Su, Fu Hsiung ; Thibault, Louise. / Effect of central glucagon infusion on macronutrient selection in rats. In: Physiology and Behavior. 1996 ; Vol. 59, No. 2. pp. 383-388.
@article{a433bd2ec1564e83a9f063ddde4be8c6,
title = "Effect of central glucagon infusion on macronutrient selection in rats",
abstract = "Compared were the light-dark pattern of absolute energy intake and macronutrient selection of male Wistar rats intracerebroventricularly infused with glucagon (5 ng/h) or saline for 7 days in a three-way selection of macronutrients. Glucagon infusion induced a decrease in 24 h and nocturnal energy intake, whereas no significant change in kcal intake accompanied vehicle infusion. The decrease in kcal intake was due to a suppression of nocturnal ingestion of carbohydrate. This parameter was left unaffected with central vehicle infusion. Glucagon-infused rats had a significantly lower body weight gain than those infused with vehicle. Our study supports the hypothesis of central glucagon's suppressive effect on food intake, but reveals that the latter reflects a lower disposition to eat carbohydrate during the dark phase. The present work emphasizes the role of glucagon in the circadian regulation of carbohydrate intake.",
keywords = "Central glucagon infusion, Energy intake, Lateral ventricle, Macronutrient selection, Rats",
author = "Naoko Komenami and Su, {Fu Hsiung} and Louise Thibault",
year = "1996",
doi = "10.1016/0031-9384(95)02108-6",
language = "English",
volume = "59",
pages = "383--388",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Effect of central glucagon infusion on macronutrient selection in rats

AU - Komenami, Naoko

AU - Su, Fu Hsiung

AU - Thibault, Louise

PY - 1996

Y1 - 1996

N2 - Compared were the light-dark pattern of absolute energy intake and macronutrient selection of male Wistar rats intracerebroventricularly infused with glucagon (5 ng/h) or saline for 7 days in a three-way selection of macronutrients. Glucagon infusion induced a decrease in 24 h and nocturnal energy intake, whereas no significant change in kcal intake accompanied vehicle infusion. The decrease in kcal intake was due to a suppression of nocturnal ingestion of carbohydrate. This parameter was left unaffected with central vehicle infusion. Glucagon-infused rats had a significantly lower body weight gain than those infused with vehicle. Our study supports the hypothesis of central glucagon's suppressive effect on food intake, but reveals that the latter reflects a lower disposition to eat carbohydrate during the dark phase. The present work emphasizes the role of glucagon in the circadian regulation of carbohydrate intake.

AB - Compared were the light-dark pattern of absolute energy intake and macronutrient selection of male Wistar rats intracerebroventricularly infused with glucagon (5 ng/h) or saline for 7 days in a three-way selection of macronutrients. Glucagon infusion induced a decrease in 24 h and nocturnal energy intake, whereas no significant change in kcal intake accompanied vehicle infusion. The decrease in kcal intake was due to a suppression of nocturnal ingestion of carbohydrate. This parameter was left unaffected with central vehicle infusion. Glucagon-infused rats had a significantly lower body weight gain than those infused with vehicle. Our study supports the hypothesis of central glucagon's suppressive effect on food intake, but reveals that the latter reflects a lower disposition to eat carbohydrate during the dark phase. The present work emphasizes the role of glucagon in the circadian regulation of carbohydrate intake.

KW - Central glucagon infusion

KW - Energy intake

KW - Lateral ventricle

KW - Macronutrient selection

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=0029919501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029919501&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(95)02108-6

DO - 10.1016/0031-9384(95)02108-6

M3 - Article

C2 - 8838620

AN - SCOPUS:0029919501

VL - 59

SP - 383

EP - 388

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 2

ER -