Effect of Angiotensin II Receptor Antagonism on Cerebral Vasomotor Reserve in Humans

Chin Hua Fu, Cheryl C H Yang, Terry B J Kuo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Angiotensin II receptor antagonists have been reported to modulate cerebrovascular flow in animals. We applied frequency-domain techniques to explore whether angiotensin II receptor activity plays a role in cerebrovascular dynamics in humans. Essential hypertensive patients with (AIIA, n = 10) and without (HT, n = 10) an angiotensin II receptor antagonist (Volsartane) and healthy with matched (CON, n = 10) and younger (YOUNG, n = 10) ages were enrolled. They underwent measurement of middle cerebral artery flow velocity (MCAFV) by transcranial Doppler ultrasound and non-invasive beat-to-beat arterial blood pressure (ABP). Fluctuations in ABP and MCAFV were diffracted into high-frequency (HF, 0.15-0.4 Hz), low-frequency (LF, 0.04-0.15 Hz), and very low-frequency (VLF, 0.016-0.04 Hz) components. The mean age did not statistically significantly differ among the CON, HT, and AIIA groups. HT had significantly higher mean ABP, lower LF fluctuations of ABP and MCAFV, but similar ABP-MCAFV transfer magnitude compared with CON. HF transfer magnitude of AIIA was significantly higher than those of HT and CON, but similar to that of YOUNG. We conclude that the elderly with chronic essential hypertension has a suppressive effect on cerebral vasomotor reserve, in which angiotensin II receptor activity may play an active role.

Original languageEnglish
Pages (from-to)714-718
Number of pages5
JournalJournal of Cardiovascular Pharmacology
Volume42
Issue number6
DOIs
Publication statusPublished - Dec 2003
Externally publishedYes

Fingerprint

Angiotensin Receptors
Arterial Pressure
Middle Cerebral Artery
Angiotensin Receptor Antagonists
Doppler Ultrasonography

Keywords

  • Cerebral autoregulation
  • Frequency domain analysis
  • Transcranial Doppler

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Cite this

Effect of Angiotensin II Receptor Antagonism on Cerebral Vasomotor Reserve in Humans. / Fu, Chin Hua; Yang, Cheryl C H; Kuo, Terry B J.

In: Journal of Cardiovascular Pharmacology, Vol. 42, No. 6, 12.2003, p. 714-718.

Research output: Contribution to journalArticle

@article{7d4adcdaf4aa4aac937ea75cbe6a92a5,
title = "Effect of Angiotensin II Receptor Antagonism on Cerebral Vasomotor Reserve in Humans",
abstract = "Angiotensin II receptor antagonists have been reported to modulate cerebrovascular flow in animals. We applied frequency-domain techniques to explore whether angiotensin II receptor activity plays a role in cerebrovascular dynamics in humans. Essential hypertensive patients with (AIIA, n = 10) and without (HT, n = 10) an angiotensin II receptor antagonist (Volsartane) and healthy with matched (CON, n = 10) and younger (YOUNG, n = 10) ages were enrolled. They underwent measurement of middle cerebral artery flow velocity (MCAFV) by transcranial Doppler ultrasound and non-invasive beat-to-beat arterial blood pressure (ABP). Fluctuations in ABP and MCAFV were diffracted into high-frequency (HF, 0.15-0.4 Hz), low-frequency (LF, 0.04-0.15 Hz), and very low-frequency (VLF, 0.016-0.04 Hz) components. The mean age did not statistically significantly differ among the CON, HT, and AIIA groups. HT had significantly higher mean ABP, lower LF fluctuations of ABP and MCAFV, but similar ABP-MCAFV transfer magnitude compared with CON. HF transfer magnitude of AIIA was significantly higher than those of HT and CON, but similar to that of YOUNG. We conclude that the elderly with chronic essential hypertension has a suppressive effect on cerebral vasomotor reserve, in which angiotensin II receptor activity may play an active role.",
keywords = "Cerebral autoregulation, Frequency domain analysis, Transcranial Doppler",
author = "Fu, {Chin Hua} and Yang, {Cheryl C H} and Kuo, {Terry B J}",
year = "2003",
month = "12",
doi = "10.1097/00005344-200312000-00004",
language = "English",
volume = "42",
pages = "714--718",
journal = "Journal of Cardiovascular Pharmacology",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Effect of Angiotensin II Receptor Antagonism on Cerebral Vasomotor Reserve in Humans

AU - Fu, Chin Hua

AU - Yang, Cheryl C H

AU - Kuo, Terry B J

PY - 2003/12

Y1 - 2003/12

N2 - Angiotensin II receptor antagonists have been reported to modulate cerebrovascular flow in animals. We applied frequency-domain techniques to explore whether angiotensin II receptor activity plays a role in cerebrovascular dynamics in humans. Essential hypertensive patients with (AIIA, n = 10) and without (HT, n = 10) an angiotensin II receptor antagonist (Volsartane) and healthy with matched (CON, n = 10) and younger (YOUNG, n = 10) ages were enrolled. They underwent measurement of middle cerebral artery flow velocity (MCAFV) by transcranial Doppler ultrasound and non-invasive beat-to-beat arterial blood pressure (ABP). Fluctuations in ABP and MCAFV were diffracted into high-frequency (HF, 0.15-0.4 Hz), low-frequency (LF, 0.04-0.15 Hz), and very low-frequency (VLF, 0.016-0.04 Hz) components. The mean age did not statistically significantly differ among the CON, HT, and AIIA groups. HT had significantly higher mean ABP, lower LF fluctuations of ABP and MCAFV, but similar ABP-MCAFV transfer magnitude compared with CON. HF transfer magnitude of AIIA was significantly higher than those of HT and CON, but similar to that of YOUNG. We conclude that the elderly with chronic essential hypertension has a suppressive effect on cerebral vasomotor reserve, in which angiotensin II receptor activity may play an active role.

AB - Angiotensin II receptor antagonists have been reported to modulate cerebrovascular flow in animals. We applied frequency-domain techniques to explore whether angiotensin II receptor activity plays a role in cerebrovascular dynamics in humans. Essential hypertensive patients with (AIIA, n = 10) and without (HT, n = 10) an angiotensin II receptor antagonist (Volsartane) and healthy with matched (CON, n = 10) and younger (YOUNG, n = 10) ages were enrolled. They underwent measurement of middle cerebral artery flow velocity (MCAFV) by transcranial Doppler ultrasound and non-invasive beat-to-beat arterial blood pressure (ABP). Fluctuations in ABP and MCAFV were diffracted into high-frequency (HF, 0.15-0.4 Hz), low-frequency (LF, 0.04-0.15 Hz), and very low-frequency (VLF, 0.016-0.04 Hz) components. The mean age did not statistically significantly differ among the CON, HT, and AIIA groups. HT had significantly higher mean ABP, lower LF fluctuations of ABP and MCAFV, but similar ABP-MCAFV transfer magnitude compared with CON. HF transfer magnitude of AIIA was significantly higher than those of HT and CON, but similar to that of YOUNG. We conclude that the elderly with chronic essential hypertension has a suppressive effect on cerebral vasomotor reserve, in which angiotensin II receptor activity may play an active role.

KW - Cerebral autoregulation

KW - Frequency domain analysis

KW - Transcranial Doppler

UR - http://www.scopus.com/inward/record.url?scp=0345448299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345448299&partnerID=8YFLogxK

U2 - 10.1097/00005344-200312000-00004

DO - 10.1097/00005344-200312000-00004

M3 - Article

C2 - 14639092

AN - SCOPUS:0345448299

VL - 42

SP - 714

EP - 718

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

SN - 0160-2446

IS - 6

ER -