Effect of age on working memory performance and cerebral activation after mild traumatic brain injury: A functional MR imaging study

David Yen Ting Chen, Hui Ling Hsu, Ying Sheng Kuo, Changwei Wesley Wu, Wen Ta Chiu, Feng Xian Yan, Wei Shuan Wang, Chi Jen Chen, Ying Chi Tseng

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the age effect on working memory (WM) performance and functional activation after mild traumatic brain injury (MTBI). Materials and Methods: This study was approved by the local research ethics committee. All participants provided written informed consent. N-back WM cerebral activation was assessed with functional magnetic resonance (MR) imaging in 13 younger (mean age, 26.2 years ± 2.9; range, 21-30 years) and 13 older (mean age, 57.8 years ± 6.6; range, 51-68 years) patients with MTBI and 26 age- and sex-matched control subjects. Two functional MR images were obtained within 1 month after injury and 6 weeks after the initial study. Group comparison and regression analysis were performed among postconcussion symptoms, neuropsychologic tests, and WM activity in both groups. Results: In younger patients, initial hyperactivation was seen in the right precuneus and right inferior parietal gyrus (P =.047 and P =.025, respectively) in two-back greater than one-back conditions compared with younger control subjects, whereas in older patients, hypoactivation was seen in the right precuneus and right inferior frontal gyrus (P =.013 and P =.019, respectively) compared with older control subjects. Increased WM activity was associated with increased postconcussion symptoms in the right precuneus (r = 0.57; P =.026) and right inferior frontal gyrus (r = 0.60; P =.019) and poor WM performance in the right precuneus (r = -0.55; P =.027) in younger patients at initial studies but not in older patients. At follow-up examinations, partial recovery of activation pattern and decreased postconcussion symptoms (P =.04) were observed in younger patients but not in older patients. Conclusion: The different manifestations of postconcussion symptoms at functional MR imaging between younger and older patients confirmed the important role of age in the activation, modulation, and allocation of WM processing resources after MTBI. These findings also supported that younger patients have better neural plasticity and clinical recovery than do older patients.

Original languageEnglish
Pages (from-to)854-862
Number of pages9
JournalRadiology
Volume278
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

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Brain Concussion
Short-Term Memory
Magnetic Resonance Imaging
Parietal Lobe
Prefrontal Cortex
Neuronal Plasticity
Neuropsychological Tests
Research Ethics Committees
Informed Consent
Magnetic Resonance Spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Effect of age on working memory performance and cerebral activation after mild traumatic brain injury : A functional MR imaging study. / Chen, David Yen Ting; Hsu, Hui Ling; Kuo, Ying Sheng; Wu, Changwei Wesley; Chiu, Wen Ta; Yan, Feng Xian; Wang, Wei Shuan; Chen, Chi Jen; Tseng, Ying Chi.

In: Radiology, Vol. 278, No. 3, 01.03.2016, p. 854-862.

Research output: Contribution to journalArticle

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abstract = "Purpose: To evaluate the age effect on working memory (WM) performance and functional activation after mild traumatic brain injury (MTBI). Materials and Methods: This study was approved by the local research ethics committee. All participants provided written informed consent. N-back WM cerebral activation was assessed with functional magnetic resonance (MR) imaging in 13 younger (mean age, 26.2 years ± 2.9; range, 21-30 years) and 13 older (mean age, 57.8 years ± 6.6; range, 51-68 years) patients with MTBI and 26 age- and sex-matched control subjects. Two functional MR images were obtained within 1 month after injury and 6 weeks after the initial study. Group comparison and regression analysis were performed among postconcussion symptoms, neuropsychologic tests, and WM activity in both groups. Results: In younger patients, initial hyperactivation was seen in the right precuneus and right inferior parietal gyrus (P =.047 and P =.025, respectively) in two-back greater than one-back conditions compared with younger control subjects, whereas in older patients, hypoactivation was seen in the right precuneus and right inferior frontal gyrus (P =.013 and P =.019, respectively) compared with older control subjects. Increased WM activity was associated with increased postconcussion symptoms in the right precuneus (r = 0.57; P =.026) and right inferior frontal gyrus (r = 0.60; P =.019) and poor WM performance in the right precuneus (r = -0.55; P =.027) in younger patients at initial studies but not in older patients. At follow-up examinations, partial recovery of activation pattern and decreased postconcussion symptoms (P =.04) were observed in younger patients but not in older patients. Conclusion: The different manifestations of postconcussion symptoms at functional MR imaging between younger and older patients confirmed the important role of age in the activation, modulation, and allocation of WM processing resources after MTBI. These findings also supported that younger patients have better neural plasticity and clinical recovery than do older patients.",
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AU - Hsu, Hui Ling

AU - Kuo, Ying Sheng

AU - Wu, Changwei Wesley

AU - Chiu, Wen Ta

AU - Yan, Feng Xian

AU - Wang, Wei Shuan

AU - Chen, Chi Jen

AU - Tseng, Ying Chi

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AB - Purpose: To evaluate the age effect on working memory (WM) performance and functional activation after mild traumatic brain injury (MTBI). Materials and Methods: This study was approved by the local research ethics committee. All participants provided written informed consent. N-back WM cerebral activation was assessed with functional magnetic resonance (MR) imaging in 13 younger (mean age, 26.2 years ± 2.9; range, 21-30 years) and 13 older (mean age, 57.8 years ± 6.6; range, 51-68 years) patients with MTBI and 26 age- and sex-matched control subjects. Two functional MR images were obtained within 1 month after injury and 6 weeks after the initial study. Group comparison and regression analysis were performed among postconcussion symptoms, neuropsychologic tests, and WM activity in both groups. Results: In younger patients, initial hyperactivation was seen in the right precuneus and right inferior parietal gyrus (P =.047 and P =.025, respectively) in two-back greater than one-back conditions compared with younger control subjects, whereas in older patients, hypoactivation was seen in the right precuneus and right inferior frontal gyrus (P =.013 and P =.019, respectively) compared with older control subjects. Increased WM activity was associated with increased postconcussion symptoms in the right precuneus (r = 0.57; P =.026) and right inferior frontal gyrus (r = 0.60; P =.019) and poor WM performance in the right precuneus (r = -0.55; P =.027) in younger patients at initial studies but not in older patients. At follow-up examinations, partial recovery of activation pattern and decreased postconcussion symptoms (P =.04) were observed in younger patients but not in older patients. Conclusion: The different manifestations of postconcussion symptoms at functional MR imaging between younger and older patients confirmed the important role of age in the activation, modulation, and allocation of WM processing resources after MTBI. These findings also supported that younger patients have better neural plasticity and clinical recovery than do older patients.

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