Effect of a lower-dose cetrorelix acetate protocol on in-vitro fertilization outcome

Chii Ruey Tzeng, Heng J. Chen, Yu Hung Lin, Bih Chwen Hsieh, Lee W. Huang, Jiann-Loung Hwang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To determine whether a low initial dosage of cetrorelix acetate could prevent a premature luteinizing hormone (LH) surge in women undergoing controlled ovarian stimulation. Method: Treatment with a recombinant follicle stimulating hormone was started on Day 3 of the menstrual cycle, and 0.125 mg of cetrorelix was injected daily from Day 5 of the ovarian stimulation until the diameter of the dominant follicle reached at least 16 mm. The dosage was then doubled and maintained at 0.250 mg/day until the day before the injection of human chorionic gonadotropin. Result: There was a significant decrease in serum LH concentration 1 day after doubling the cetrorelix dosage, and the LH concentration remained low during the follicular phase. Clinical pregnancy occurred in 18 women (42.8%), with 2 intrauterine fetal deaths before the 12th week. Conclusion: Increasing the cetrorelix dosage from 0.125 to 0.250 mg/day when the follicular size is appropriate can prevent a premature LH surge.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume100
Issue number3
DOIs
Publication statusPublished - Mar 2008

Fingerprint

Fertilization in Vitro
Luteinizing Hormone
Ovulation Induction
Fetal Death
Follicular Phase
Follicle Stimulating Hormone
Chorionic Gonadotropin
Menstrual Cycle
Pregnancy
Injections
cetrorelix
Serum
Therapeutics

Keywords

  • Cetrorelix acetate
  • Gonadotrophin-releasing hormone antagonist
  • In-vitro fertilization
  • Lower dose
  • Luteinizing hormone surge

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Effect of a lower-dose cetrorelix acetate protocol on in-vitro fertilization outcome. / Tzeng, Chii Ruey; Chen, Heng J.; Lin, Yu Hung; Hsieh, Bih Chwen; Huang, Lee W.; Hwang, Jiann-Loung.

In: International Journal of Gynecology and Obstetrics, Vol. 100, No. 3, 03.2008, p. 271-274.

Research output: Contribution to journalArticle

Tzeng, Chii Ruey ; Chen, Heng J. ; Lin, Yu Hung ; Hsieh, Bih Chwen ; Huang, Lee W. ; Hwang, Jiann-Loung. / Effect of a lower-dose cetrorelix acetate protocol on in-vitro fertilization outcome. In: International Journal of Gynecology and Obstetrics. 2008 ; Vol. 100, No. 3. pp. 271-274.
@article{19b46a3644fb4428b4197c0d24e08c0c,
title = "Effect of a lower-dose cetrorelix acetate protocol on in-vitro fertilization outcome",
abstract = "Objective: To determine whether a low initial dosage of cetrorelix acetate could prevent a premature luteinizing hormone (LH) surge in women undergoing controlled ovarian stimulation. Method: Treatment with a recombinant follicle stimulating hormone was started on Day 3 of the menstrual cycle, and 0.125 mg of cetrorelix was injected daily from Day 5 of the ovarian stimulation until the diameter of the dominant follicle reached at least 16 mm. The dosage was then doubled and maintained at 0.250 mg/day until the day before the injection of human chorionic gonadotropin. Result: There was a significant decrease in serum LH concentration 1 day after doubling the cetrorelix dosage, and the LH concentration remained low during the follicular phase. Clinical pregnancy occurred in 18 women (42.8{\%}), with 2 intrauterine fetal deaths before the 12th week. Conclusion: Increasing the cetrorelix dosage from 0.125 to 0.250 mg/day when the follicular size is appropriate can prevent a premature LH surge.",
keywords = "Cetrorelix acetate, Gonadotrophin-releasing hormone antagonist, In-vitro fertilization, Lower dose, Luteinizing hormone surge",
author = "Tzeng, {Chii Ruey} and Chen, {Heng J.} and Lin, {Yu Hung} and Hsieh, {Bih Chwen} and Huang, {Lee W.} and Jiann-Loung Hwang",
year = "2008",
month = "3",
doi = "10.1016/j.ijgo.2007.09.024",
language = "English",
volume = "100",
pages = "271--274",
journal = "International Journal of Gynecology and Obstetrics",
issn = "0020-7292",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Effect of a lower-dose cetrorelix acetate protocol on in-vitro fertilization outcome

AU - Tzeng, Chii Ruey

AU - Chen, Heng J.

AU - Lin, Yu Hung

AU - Hsieh, Bih Chwen

AU - Huang, Lee W.

AU - Hwang, Jiann-Loung

PY - 2008/3

Y1 - 2008/3

N2 - Objective: To determine whether a low initial dosage of cetrorelix acetate could prevent a premature luteinizing hormone (LH) surge in women undergoing controlled ovarian stimulation. Method: Treatment with a recombinant follicle stimulating hormone was started on Day 3 of the menstrual cycle, and 0.125 mg of cetrorelix was injected daily from Day 5 of the ovarian stimulation until the diameter of the dominant follicle reached at least 16 mm. The dosage was then doubled and maintained at 0.250 mg/day until the day before the injection of human chorionic gonadotropin. Result: There was a significant decrease in serum LH concentration 1 day after doubling the cetrorelix dosage, and the LH concentration remained low during the follicular phase. Clinical pregnancy occurred in 18 women (42.8%), with 2 intrauterine fetal deaths before the 12th week. Conclusion: Increasing the cetrorelix dosage from 0.125 to 0.250 mg/day when the follicular size is appropriate can prevent a premature LH surge.

AB - Objective: To determine whether a low initial dosage of cetrorelix acetate could prevent a premature luteinizing hormone (LH) surge in women undergoing controlled ovarian stimulation. Method: Treatment with a recombinant follicle stimulating hormone was started on Day 3 of the menstrual cycle, and 0.125 mg of cetrorelix was injected daily from Day 5 of the ovarian stimulation until the diameter of the dominant follicle reached at least 16 mm. The dosage was then doubled and maintained at 0.250 mg/day until the day before the injection of human chorionic gonadotropin. Result: There was a significant decrease in serum LH concentration 1 day after doubling the cetrorelix dosage, and the LH concentration remained low during the follicular phase. Clinical pregnancy occurred in 18 women (42.8%), with 2 intrauterine fetal deaths before the 12th week. Conclusion: Increasing the cetrorelix dosage from 0.125 to 0.250 mg/day when the follicular size is appropriate can prevent a premature LH surge.

KW - Cetrorelix acetate

KW - Gonadotrophin-releasing hormone antagonist

KW - In-vitro fertilization

KW - Lower dose

KW - Luteinizing hormone surge

UR - http://www.scopus.com/inward/record.url?scp=39149107162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=39149107162&partnerID=8YFLogxK

U2 - 10.1016/j.ijgo.2007.09.024

DO - 10.1016/j.ijgo.2007.09.024

M3 - Article

C2 - 18045601

AN - SCOPUS:39149107162

VL - 100

SP - 271

EP - 274

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

SN - 0020-7292

IS - 3

ER -