Effect of a lower-dose cetrorelix acetate protocol on in-vitro fertilization outcome

Chii Ruey Tzeng, Heng J. Chen, Yu Hung Lin, Bih Chwen Hsieh, Lee W. Huang, Jiann-Loung Hwang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To determine whether a low initial dosage of cetrorelix acetate could prevent a premature luteinizing hormone (LH) surge in women undergoing controlled ovarian stimulation. Method: Treatment with a recombinant follicle stimulating hormone was started on Day 3 of the menstrual cycle, and 0.125 mg of cetrorelix was injected daily from Day 5 of the ovarian stimulation until the diameter of the dominant follicle reached at least 16 mm. The dosage was then doubled and maintained at 0.250 mg/day until the day before the injection of human chorionic gonadotropin. Result: There was a significant decrease in serum LH concentration 1 day after doubling the cetrorelix dosage, and the LH concentration remained low during the follicular phase. Clinical pregnancy occurred in 18 women (42.8%), with 2 intrauterine fetal deaths before the 12th week. Conclusion: Increasing the cetrorelix dosage from 0.125 to 0.250 mg/day when the follicular size is appropriate can prevent a premature LH surge.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume100
Issue number3
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Cetrorelix acetate
  • Gonadotrophin-releasing hormone antagonist
  • In-vitro fertilization
  • Lower dose
  • Luteinizing hormone surge

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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