Effect of a computer-aided diagnosis system on radiologists' performance in grading gliomas with MRI

Kevin Li Chun Hsieh, Ruei Je Tsai, Yu Chuan Teng, Chung Ming Lo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of a computer-aided diagnosis (CAD) system based on quantitative intensity features with magnetic resonance (MR) imaging (MRI) were evaluated by examining radiologists' performance in grading gliomas. The acquired MRI database included 71 lower-grade gliomas and 34 glioblastomas. Quantitative image features were extracted from the tumor area and combined in a CAD system to generate a prediction model. The effect of the CAD system was evaluated in a two-stage procedure. First, a radiologist performed a conventional reading. A sequential second reading was determined with a malignancy estimation by the CAD system. Each MR image was regularly read by one radiologist out of a group of three radiologists. The CAD system achieved an accuracy of 87% (91/105), a sensitivity of 79% (27/34), a specificity of 90% (64/71), and an area under the receiver operating characteristic curve (Az) of 0.89. In the evaluation, the radiologists' Az values significantly improved from 0.81, 0.87, and 0.84 to 0.90, 0.90, and 0.88 with p = 0.0011, 0.0076, and 0.0167, respectively. Based on the MR image features, the proposed CAD system not only performed well in distinguishing glioblastomas from lower-grade gliomas but also provided suggestions about glioma grading to reinforce radiologists' confidence rating.

Original languageEnglish
Article numbere0171342
JournalPLoS One
Volume12
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

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Computer aided diagnosis
Glioma
image analysis
Imaging techniques
Magnetic resonance
Glioblastoma
Reading
Magnetic Resonance Spectroscopy
magnetic resonance imaging
ROC Curve
Radiologists
Tumors
Neoplasms
Magnetic Resonance Imaging
Databases
neoplasms
prediction

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Effect of a computer-aided diagnosis system on radiologists' performance in grading gliomas with MRI. / Hsieh, Kevin Li Chun; Tsai, Ruei Je; Teng, Yu Chuan; Lo, Chung Ming.

In: PLoS One, Vol. 12, No. 2, e0171342, 01.02.2017.

Research output: Contribution to journalArticle

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