EBV-associated Burkitt lymphoma in Taiwan is not age-related

Bo Jung Chen, Sheng Tsung Chang, Shih Feng Weng, Wan Ting Huang, Pei Yi Chu, Pin Pen Hsieh, Yun Chih Jung, Chun Chi Kuo, Yu Ting Chuang, Shih Sung Chuang

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

This study retrospectively investigated 54 cases of sporadic Burkitt lymphoma in Taiwan with histopathology review, immunohistochemistry, Epstein-Barr virus (EBV) in situ hybridization (EBER) and fluorescence in situ hybridization (FISH). The great majority revealed typical immunophenotype and 89% (47/53) cases expressed myc protein. EBER was positive in 20% (11/54) of cases, more frequently with nodal presentation, but not significantly associated with age (pediatric vs adult), abdominal vs extra-abdominal presentation or overall survival (OS). MYC and IGH were rearranged in 94% (46/49) and 85% (41/48) of cases, respectively. The concordance rate between myc expression and MYC translocation was 83% (40/48). By univariate analysis, OS was statistically associated with age, with or without chemotherapy, central nervous system (CNS) involvement, CNS prophylaxis and leukemic transformation, but not gender, nodal vs extranodal involvement, stage, immunohistochemistry, EBER, myc expression, MYC translocation or radiotherapy. By multivariate analysis, CNS involvement at presentation and administration of chemotherapy were statistically associated with OS.

Original languageEnglish
Pages (from-to)644-653
Number of pages10
JournalLeukemia and Lymphoma
Volume57
Issue number3
DOIs
Publication statusPublished - Mar 3 2016

Keywords

  • Burkitt lymphoma
  • EBV
  • Fluorescence in situ hybridization
  • MYC
  • Taiwan

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'EBV-associated Burkitt lymphoma in Taiwan is not age-related'. Together they form a unique fingerprint.

Cite this