Abstract

Evaluation of acute white matter injuries caused by carbon monoxide (CO) poisoning can be limited by conventional magnetic resonance (MR) imaging. We aim to evaluate the feasibility of diffusion kurtosis imaging (DKI) for early detection of white matter alterations in patients with acute CO intoxication. A total of 30 subjects including 15 acute CO patients and 15 age- and sex-matched healthy volunteers were enrolled in this study. MR examinations were performed on a 3T MR scanner within 8 days after CO intoxication. DKI data were acquired to derive axial, radial, and mean kurtosis, as well as fractional anisotropy (FA), axial, radial, and mean diffusivity for tract-specific comparisons between the 2 groups. Significant decreases of mean kurtosis were shown in the genu of corpus callosum, cingulum, and motor-related tracts (corticospinal and corticobulbar tracts) in patients with acute CO intoxication as compared with controls. On the contrary, significant differences of FA values were merely shown in the regions of corticospinal tracts. DKI demonstrated comparably stronger potential than diffusion tensor imaging in terms of early detection of white matter changes in patients with acute CO intoxication. This may have implications in therapeutic strategy for managing acute CO intoxication patients.

Original languageEnglish
Article number00032
JournalMedicine (United States)
Volume96
Issue number5
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Carbon Monoxide
Pyramidal Tracts
Wounds and Injuries
Anisotropy
Magnetic Resonance Spectroscopy
Carbon Monoxide Poisoning
Diffusion Tensor Imaging
Corpus Callosum
White Matter
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • acute CO intoxication
  • DKI
  • DTI
  • FA
  • MK
  • non-Gaussian

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Early white matter injuries in patients with acute carbon monoxide intoxication. / Tsai, Ping Huei; Chou, Ming Chung; Chiang, Shih Wei; Chung, Hsiao Wen; Liu, Hua Shan; Kao, Hung Wen; Chen, Cheng Yu.

In: Medicine (United States), Vol. 96, No. 5, 00032, 01.02.2017.

Research output: Contribution to journalArticle

Tsai, Ping Huei ; Chou, Ming Chung ; Chiang, Shih Wei ; Chung, Hsiao Wen ; Liu, Hua Shan ; Kao, Hung Wen ; Chen, Cheng Yu. / Early white matter injuries in patients with acute carbon monoxide intoxication. In: Medicine (United States). 2017 ; Vol. 96, No. 5.
@article{90d23df481684063b780ae9bc3fd114d,
title = "Early white matter injuries in patients with acute carbon monoxide intoxication",
abstract = "Evaluation of acute white matter injuries caused by carbon monoxide (CO) poisoning can be limited by conventional magnetic resonance (MR) imaging. We aim to evaluate the feasibility of diffusion kurtosis imaging (DKI) for early detection of white matter alterations in patients with acute CO intoxication. A total of 30 subjects including 15 acute CO patients and 15 age- and sex-matched healthy volunteers were enrolled in this study. MR examinations were performed on a 3T MR scanner within 8 days after CO intoxication. DKI data were acquired to derive axial, radial, and mean kurtosis, as well as fractional anisotropy (FA), axial, radial, and mean diffusivity for tract-specific comparisons between the 2 groups. Significant decreases of mean kurtosis were shown in the genu of corpus callosum, cingulum, and motor-related tracts (corticospinal and corticobulbar tracts) in patients with acute CO intoxication as compared with controls. On the contrary, significant differences of FA values were merely shown in the regions of corticospinal tracts. DKI demonstrated comparably stronger potential than diffusion tensor imaging in terms of early detection of white matter changes in patients with acute CO intoxication. This may have implications in therapeutic strategy for managing acute CO intoxication patients.",
keywords = "acute CO intoxication, DKI, DTI, FA, MK, non-Gaussian",
author = "Tsai, {Ping Huei} and Chou, {Ming Chung} and Chiang, {Shih Wei} and Chung, {Hsiao Wen} and Liu, {Hua Shan} and Kao, {Hung Wen} and Chen, {Cheng Yu}",
year = "2017",
month = "2",
day = "1",
doi = "10.1097/MD.0000000000005982",
language = "English",
volume = "96",
journal = "Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries",
issn = "0025-7974",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Early white matter injuries in patients with acute carbon monoxide intoxication

AU - Tsai, Ping Huei

AU - Chou, Ming Chung

AU - Chiang, Shih Wei

AU - Chung, Hsiao Wen

AU - Liu, Hua Shan

AU - Kao, Hung Wen

AU - Chen, Cheng Yu

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Evaluation of acute white matter injuries caused by carbon monoxide (CO) poisoning can be limited by conventional magnetic resonance (MR) imaging. We aim to evaluate the feasibility of diffusion kurtosis imaging (DKI) for early detection of white matter alterations in patients with acute CO intoxication. A total of 30 subjects including 15 acute CO patients and 15 age- and sex-matched healthy volunteers were enrolled in this study. MR examinations were performed on a 3T MR scanner within 8 days after CO intoxication. DKI data were acquired to derive axial, radial, and mean kurtosis, as well as fractional anisotropy (FA), axial, radial, and mean diffusivity for tract-specific comparisons between the 2 groups. Significant decreases of mean kurtosis were shown in the genu of corpus callosum, cingulum, and motor-related tracts (corticospinal and corticobulbar tracts) in patients with acute CO intoxication as compared with controls. On the contrary, significant differences of FA values were merely shown in the regions of corticospinal tracts. DKI demonstrated comparably stronger potential than diffusion tensor imaging in terms of early detection of white matter changes in patients with acute CO intoxication. This may have implications in therapeutic strategy for managing acute CO intoxication patients.

AB - Evaluation of acute white matter injuries caused by carbon monoxide (CO) poisoning can be limited by conventional magnetic resonance (MR) imaging. We aim to evaluate the feasibility of diffusion kurtosis imaging (DKI) for early detection of white matter alterations in patients with acute CO intoxication. A total of 30 subjects including 15 acute CO patients and 15 age- and sex-matched healthy volunteers were enrolled in this study. MR examinations were performed on a 3T MR scanner within 8 days after CO intoxication. DKI data were acquired to derive axial, radial, and mean kurtosis, as well as fractional anisotropy (FA), axial, radial, and mean diffusivity for tract-specific comparisons between the 2 groups. Significant decreases of mean kurtosis were shown in the genu of corpus callosum, cingulum, and motor-related tracts (corticospinal and corticobulbar tracts) in patients with acute CO intoxication as compared with controls. On the contrary, significant differences of FA values were merely shown in the regions of corticospinal tracts. DKI demonstrated comparably stronger potential than diffusion tensor imaging in terms of early detection of white matter changes in patients with acute CO intoxication. This may have implications in therapeutic strategy for managing acute CO intoxication patients.

KW - acute CO intoxication

KW - DKI

KW - DTI

KW - FA

KW - MK

KW - non-Gaussian

UR - http://www.scopus.com/inward/record.url?scp=85013157966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013157966&partnerID=8YFLogxK

U2 - 10.1097/MD.0000000000005982

DO - 10.1097/MD.0000000000005982

M3 - Article

C2 - 28151889

AN - SCOPUS:85013726921

VL - 96

JO - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

JF - Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries

SN - 0025-7974

IS - 5

M1 - 00032

ER -