Cell-based systems are useful for discovering antiviral agents. Dissecting the viral life cycle, particularly the early entry stages, allows a mechanistic approach to identify and evaluate antiviral agents that target specific steps of the viral entry. In this report, the methods of examining viral inactivation, viral attachment, and viral entry/fusion as antiviral assays for such purposes are described, using hepatitis C virus as a model. These assays should be useful for discovering novel antagonists/inhibitors to early viral entry and help expand the scope of candidate antiviral agents for further drug development.

Original languageEnglish
Article numbere53124
JournalJournal of Visualized Experiments
Issue number104
Publication statusPublished - Oct 29 2015


  • Antiviral activity
  • Drug development
  • Early viral entry
  • Immunology
  • Issue 104
  • Viral attachment/binding
  • Viral entry/fusion
  • Viral inactivation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)


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