Early seizures after severe closed head injury

Shih Tseng Lee, Tai Ngar Lui, Cheuk Wah Wong, Yi Shen Yeh, Wen Ching Tzaan, Tzu Yung Chen, Shang Yu Hung, Chieh Tsai Wu

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: We studied the incidence and clinical significance of early post-traumatic seizures after severe closed head injury. Methods: This prospective study is based on clinical observation of 3340 adult patients with severe closed head injuries, each of them having a Glasgow Coma Scale (GCS) 3 to 8 after trauma. Anticonvulsant agents were not given to these patients unless there was evidence of seizure. Results: One hundred and twenty-one patients (3.6%) experienced seizures within 1 week after head injury; 42 of these (1.26% of the series) had seizures within 24 hours after trauma. The incidence of intracerebral parenchymal damage was found to be higher among those patients who developed seizures in the first week (66.1%) than in those who did not (62.7%). However this result did not reach statistical significance. The patients with early seizures had a lower mortality rate (p <0.01). In patients who survived from the initial injury, the occurrence of early post-traumatic seizures did not appear to influence the neurological recovery at 6 months after injury. Conclusion: Presence of intracerebral parenchymal damage on CT scan after severe closed head injury does not increase the risk of early post-traumatic seizures. With proper treatment, patients presenting with early seizures may have a lower mortality rate. However, the occurrence of early seizures does not influence the neurological recovery in patients who survive the initial severe closed head injury.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalCanadian Journal of Neurological Sciences
Volume24
Issue number1
Publication statusPublished - Feb 1997
Externally publishedYes

Fingerprint

Closed Head Injuries
Seizures
Post-Traumatic Epilepsy
Wounds and Injuries
Glasgow Coma Scale
Mortality
Incidence
Craniocerebral Trauma
Anticonvulsants
Observation
Prospective Studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Lee, S. T., Lui, T. N., Wong, C. W., Yeh, Y. S., Tzaan, W. C., Chen, T. Y., ... Wu, C. T. (1997). Early seizures after severe closed head injury. Canadian Journal of Neurological Sciences, 24(1), 40-43.

Early seizures after severe closed head injury. / Lee, Shih Tseng; Lui, Tai Ngar; Wong, Cheuk Wah; Yeh, Yi Shen; Tzaan, Wen Ching; Chen, Tzu Yung; Hung, Shang Yu; Wu, Chieh Tsai.

In: Canadian Journal of Neurological Sciences, Vol. 24, No. 1, 02.1997, p. 40-43.

Research output: Contribution to journalArticle

Lee, ST, Lui, TN, Wong, CW, Yeh, YS, Tzaan, WC, Chen, TY, Hung, SY & Wu, CT 1997, 'Early seizures after severe closed head injury', Canadian Journal of Neurological Sciences, vol. 24, no. 1, pp. 40-43.
Lee ST, Lui TN, Wong CW, Yeh YS, Tzaan WC, Chen TY et al. Early seizures after severe closed head injury. Canadian Journal of Neurological Sciences. 1997 Feb;24(1):40-43.
Lee, Shih Tseng ; Lui, Tai Ngar ; Wong, Cheuk Wah ; Yeh, Yi Shen ; Tzaan, Wen Ching ; Chen, Tzu Yung ; Hung, Shang Yu ; Wu, Chieh Tsai. / Early seizures after severe closed head injury. In: Canadian Journal of Neurological Sciences. 1997 ; Vol. 24, No. 1. pp. 40-43.
@article{358a3e56cb8b42fbad7cd361f47322b5,
title = "Early seizures after severe closed head injury",
abstract = "Background: We studied the incidence and clinical significance of early post-traumatic seizures after severe closed head injury. Methods: This prospective study is based on clinical observation of 3340 adult patients with severe closed head injuries, each of them having a Glasgow Coma Scale (GCS) 3 to 8 after trauma. Anticonvulsant agents were not given to these patients unless there was evidence of seizure. Results: One hundred and twenty-one patients (3.6{\%}) experienced seizures within 1 week after head injury; 42 of these (1.26{\%} of the series) had seizures within 24 hours after trauma. The incidence of intracerebral parenchymal damage was found to be higher among those patients who developed seizures in the first week (66.1{\%}) than in those who did not (62.7{\%}). However this result did not reach statistical significance. The patients with early seizures had a lower mortality rate (p <0.01). In patients who survived from the initial injury, the occurrence of early post-traumatic seizures did not appear to influence the neurological recovery at 6 months after injury. Conclusion: Presence of intracerebral parenchymal damage on CT scan after severe closed head injury does not increase the risk of early post-traumatic seizures. With proper treatment, patients presenting with early seizures may have a lower mortality rate. However, the occurrence of early seizures does not influence the neurological recovery in patients who survive the initial severe closed head injury.",
author = "Lee, {Shih Tseng} and Lui, {Tai Ngar} and Wong, {Cheuk Wah} and Yeh, {Yi Shen} and Tzaan, {Wen Ching} and Chen, {Tzu Yung} and Hung, {Shang Yu} and Wu, {Chieh Tsai}",
year = "1997",
month = "2",
language = "English",
volume = "24",
pages = "40--43",
journal = "Canadian Journal of Neurological Sciences",
issn = "0317-1671",
publisher = "Canadian Journal of Neurological Sciences",
number = "1",

}

TY - JOUR

T1 - Early seizures after severe closed head injury

AU - Lee, Shih Tseng

AU - Lui, Tai Ngar

AU - Wong, Cheuk Wah

AU - Yeh, Yi Shen

AU - Tzaan, Wen Ching

AU - Chen, Tzu Yung

AU - Hung, Shang Yu

AU - Wu, Chieh Tsai

PY - 1997/2

Y1 - 1997/2

N2 - Background: We studied the incidence and clinical significance of early post-traumatic seizures after severe closed head injury. Methods: This prospective study is based on clinical observation of 3340 adult patients with severe closed head injuries, each of them having a Glasgow Coma Scale (GCS) 3 to 8 after trauma. Anticonvulsant agents were not given to these patients unless there was evidence of seizure. Results: One hundred and twenty-one patients (3.6%) experienced seizures within 1 week after head injury; 42 of these (1.26% of the series) had seizures within 24 hours after trauma. The incidence of intracerebral parenchymal damage was found to be higher among those patients who developed seizures in the first week (66.1%) than in those who did not (62.7%). However this result did not reach statistical significance. The patients with early seizures had a lower mortality rate (p <0.01). In patients who survived from the initial injury, the occurrence of early post-traumatic seizures did not appear to influence the neurological recovery at 6 months after injury. Conclusion: Presence of intracerebral parenchymal damage on CT scan after severe closed head injury does not increase the risk of early post-traumatic seizures. With proper treatment, patients presenting with early seizures may have a lower mortality rate. However, the occurrence of early seizures does not influence the neurological recovery in patients who survive the initial severe closed head injury.

AB - Background: We studied the incidence and clinical significance of early post-traumatic seizures after severe closed head injury. Methods: This prospective study is based on clinical observation of 3340 adult patients with severe closed head injuries, each of them having a Glasgow Coma Scale (GCS) 3 to 8 after trauma. Anticonvulsant agents were not given to these patients unless there was evidence of seizure. Results: One hundred and twenty-one patients (3.6%) experienced seizures within 1 week after head injury; 42 of these (1.26% of the series) had seizures within 24 hours after trauma. The incidence of intracerebral parenchymal damage was found to be higher among those patients who developed seizures in the first week (66.1%) than in those who did not (62.7%). However this result did not reach statistical significance. The patients with early seizures had a lower mortality rate (p <0.01). In patients who survived from the initial injury, the occurrence of early post-traumatic seizures did not appear to influence the neurological recovery at 6 months after injury. Conclusion: Presence of intracerebral parenchymal damage on CT scan after severe closed head injury does not increase the risk of early post-traumatic seizures. With proper treatment, patients presenting with early seizures may have a lower mortality rate. However, the occurrence of early seizures does not influence the neurological recovery in patients who survive the initial severe closed head injury.

UR - http://www.scopus.com/inward/record.url?scp=0031059093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031059093&partnerID=8YFLogxK

M3 - Article

C2 - 9043746

AN - SCOPUS:0031059093

VL - 24

SP - 40

EP - 43

JO - Canadian Journal of Neurological Sciences

JF - Canadian Journal of Neurological Sciences

SN - 0317-1671

IS - 1

ER -