Early-onset septicemia due to CMY-2-producing Escherichia coli in a woman with blunt abdominal trauma

Khee Siang Chan, Wen Liang Yu, Chen Y. Kuo, Chi L. Tsai, Yin Ching Chuang

Research output: Contribution to journalArticle

Abstract

Escherichia coli remains one of the most common etiologies of secondary peritonitis. CMY-2 is the most prevalent AmpC enzyme identified in nosocomial E. coli isolates causing bacteremia in Taiwan. This report is of a patient who underwent surgery for intestinal perforations due to blunt abdominal trauma and developed unexpected CMY-2-producing E. coli septicemia in the early postoperative period. The AmpC-type CMY-2 enzyme night partially contribute to the poor response to antimicrobial therapy of amoxicillin-clavulanic acid or flornoxef. Late changes in antibiotic therapy to an appropriate regimen of cefpirome based on the culture results did not result in a positive outcome and the patient died. Whether selection of an anti-AmpC regimen is appropriate as first-line treatment for traumatic abdomen-associated septicemia should be an area of further investigation in Taiwan.

Original languageEnglish
Pages (from-to)442-444
Number of pages3
JournalJournal of Microbiology, Immunology and Infection
Volume42
Issue number5
Publication statusPublished - Oct 2009

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Keywords

  • AmpC beta-lactamases
  • Beta-lactamase CMY-2
  • Escherichia coli
  • Peritonitis

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Immunology and Allergy
  • Infectious Diseases
  • Microbiology (medical)

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