Abstract

Background: Results from previous studies regarding relationships between age at menarche and cardiovascular disease remain controversial. This study investigated the association between endogenous estrogen exposure and ischemic stroke risk. Methods: A total of 189 ischemic stroke patients and 192 age-matched healthy postmenopausal women were recruited. Age at menarche and menopause and risk factors of ischemic stroke were recorded through structured questionnaires by well-trained research assistants. Lifetime estrogen exposure was calculated as the number of years between age of menarche and menopause. Results: Study subjects with a history of hypertension and diabetes mellitus have a 2.8- and 6.2-fold increased risk for ischemic stroke, respectively. In addition, study subjects with waist circumferences ≥80 cm also have a 2.6-fold increased risk of ischemic stroke. Conversely, subjects who experienced menarche at an early age may have a significantly decreased risk of 0.3-fold for ischemic stroke. Moreover, there was a significant and joint protective effect for study subjects without any risk factors of ischemic stroke, including a history of hypertension and diabetes mellitus, late age at menarche, and shorter lifetime estrogen exposure; these subjects were found to have the lowest risk (0.03-fold) for the development of ischemic stroke. Conclusion: Our study provides strong evidence that a significant joint protective effect was observed for patients who undergo early menarche, have longer estrogen exposure and no history of hypertension or diabetes mellitus on the risk of ischemic stroke.

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalInternational Journal of Gerontology
Volume4
Issue number1
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Menarche
Stroke
Estrogens
Diabetes Mellitus
Menopause
Hypertension
Waist Circumference
Cardiovascular Diseases

Keywords

  • Ischemic stroke
  • Menarche
  • Menopause

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Early menarche and ischemic stroke risk among postmenopausal women. / Hsieh, Yi Chen; Hwang, Lee Ching; Hsieh, Fang I.; Lien, Li Ming; Lin, Huey Juan; Hu, Chaur Jong; Tseng, Hung Pin; Bai, Chyi Huey; Chiou, Hung Yi.

In: International Journal of Gerontology, Vol. 4, No. 1, 03.2010, p. 16-22.

Research output: Contribution to journalArticle

@article{20635ececaed4ca3870c0008698e2a42,
title = "Early menarche and ischemic stroke risk among postmenopausal women",
abstract = "Background: Results from previous studies regarding relationships between age at menarche and cardiovascular disease remain controversial. This study investigated the association between endogenous estrogen exposure and ischemic stroke risk. Methods: A total of 189 ischemic stroke patients and 192 age-matched healthy postmenopausal women were recruited. Age at menarche and menopause and risk factors of ischemic stroke were recorded through structured questionnaires by well-trained research assistants. Lifetime estrogen exposure was calculated as the number of years between age of menarche and menopause. Results: Study subjects with a history of hypertension and diabetes mellitus have a 2.8- and 6.2-fold increased risk for ischemic stroke, respectively. In addition, study subjects with waist circumferences ≥80 cm also have a 2.6-fold increased risk of ischemic stroke. Conversely, subjects who experienced menarche at an early age may have a significantly decreased risk of 0.3-fold for ischemic stroke. Moreover, there was a significant and joint protective effect for study subjects without any risk factors of ischemic stroke, including a history of hypertension and diabetes mellitus, late age at menarche, and shorter lifetime estrogen exposure; these subjects were found to have the lowest risk (0.03-fold) for the development of ischemic stroke. Conclusion: Our study provides strong evidence that a significant joint protective effect was observed for patients who undergo early menarche, have longer estrogen exposure and no history of hypertension or diabetes mellitus on the risk of ischemic stroke.",
keywords = "Ischemic stroke, Menarche, Menopause",
author = "Hsieh, {Yi Chen} and Hwang, {Lee Ching} and Hsieh, {Fang I.} and Lien, {Li Ming} and Lin, {Huey Juan} and Hu, {Chaur Jong} and Tseng, {Hung Pin} and Bai, {Chyi Huey} and Chiou, {Hung Yi}",
year = "2010",
month = "3",
doi = "10.1016/S1873-9598(10)70017-X",
language = "English",
volume = "4",
pages = "16--22",
journal = "International Journal of Gerontology",
issn = "1873-9598",
publisher = "Elsevier Taiwan LLC",
number = "1",

}

TY - JOUR

T1 - Early menarche and ischemic stroke risk among postmenopausal women

AU - Hsieh, Yi Chen

AU - Hwang, Lee Ching

AU - Hsieh, Fang I.

AU - Lien, Li Ming

AU - Lin, Huey Juan

AU - Hu, Chaur Jong

AU - Tseng, Hung Pin

AU - Bai, Chyi Huey

AU - Chiou, Hung Yi

PY - 2010/3

Y1 - 2010/3

N2 - Background: Results from previous studies regarding relationships between age at menarche and cardiovascular disease remain controversial. This study investigated the association between endogenous estrogen exposure and ischemic stroke risk. Methods: A total of 189 ischemic stroke patients and 192 age-matched healthy postmenopausal women were recruited. Age at menarche and menopause and risk factors of ischemic stroke were recorded through structured questionnaires by well-trained research assistants. Lifetime estrogen exposure was calculated as the number of years between age of menarche and menopause. Results: Study subjects with a history of hypertension and diabetes mellitus have a 2.8- and 6.2-fold increased risk for ischemic stroke, respectively. In addition, study subjects with waist circumferences ≥80 cm also have a 2.6-fold increased risk of ischemic stroke. Conversely, subjects who experienced menarche at an early age may have a significantly decreased risk of 0.3-fold for ischemic stroke. Moreover, there was a significant and joint protective effect for study subjects without any risk factors of ischemic stroke, including a history of hypertension and diabetes mellitus, late age at menarche, and shorter lifetime estrogen exposure; these subjects were found to have the lowest risk (0.03-fold) for the development of ischemic stroke. Conclusion: Our study provides strong evidence that a significant joint protective effect was observed for patients who undergo early menarche, have longer estrogen exposure and no history of hypertension or diabetes mellitus on the risk of ischemic stroke.

AB - Background: Results from previous studies regarding relationships between age at menarche and cardiovascular disease remain controversial. This study investigated the association between endogenous estrogen exposure and ischemic stroke risk. Methods: A total of 189 ischemic stroke patients and 192 age-matched healthy postmenopausal women were recruited. Age at menarche and menopause and risk factors of ischemic stroke were recorded through structured questionnaires by well-trained research assistants. Lifetime estrogen exposure was calculated as the number of years between age of menarche and menopause. Results: Study subjects with a history of hypertension and diabetes mellitus have a 2.8- and 6.2-fold increased risk for ischemic stroke, respectively. In addition, study subjects with waist circumferences ≥80 cm also have a 2.6-fold increased risk of ischemic stroke. Conversely, subjects who experienced menarche at an early age may have a significantly decreased risk of 0.3-fold for ischemic stroke. Moreover, there was a significant and joint protective effect for study subjects without any risk factors of ischemic stroke, including a history of hypertension and diabetes mellitus, late age at menarche, and shorter lifetime estrogen exposure; these subjects were found to have the lowest risk (0.03-fold) for the development of ischemic stroke. Conclusion: Our study provides strong evidence that a significant joint protective effect was observed for patients who undergo early menarche, have longer estrogen exposure and no history of hypertension or diabetes mellitus on the risk of ischemic stroke.

KW - Ischemic stroke

KW - Menarche

KW - Menopause

UR - http://www.scopus.com/inward/record.url?scp=77952831953&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77952831953&partnerID=8YFLogxK

U2 - 10.1016/S1873-9598(10)70017-X

DO - 10.1016/S1873-9598(10)70017-X

M3 - Article

AN - SCOPUS:77952831953

VL - 4

SP - 16

EP - 22

JO - International Journal of Gerontology

JF - International Journal of Gerontology

SN - 1873-9598

IS - 1

ER -