Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population

Yen Ching Chen, David C. Christiani, Huey Jen Jenny Su, Yu Mei Hsueh, Thomas J. Smith, Louise M. Ryan, Sheau Chiou Chao, Julia Yu Yun Lee, Yue Liang Leon Guo

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background It has been widely accepted that sun exposure is a risk factor of squamous cell carcinoma (SCC) among fair-skinned populations. However, sun exposure and sun reaction have not been explored in Asians and no gender-specific data were available. Method In a case-control study, 176 incident skin cancer cases were recruited from National Cheng-Kung University Medical Center from 1996 to 1999. Controls included 216 age-, gender-, and residency-matched subjects from the southwestern Taiwan. A questionnaire was administered to collect information on life style and other risk factors. Logistic regression analysis was performed to evaluate the association between sun exposure or sun reaction and the risk of SCC by gender. Results Early-age (age 15 to 24) and lifetime sun exposure were significantly associated with increased risk of SCC in a dose-response pattern [odds ratio (OR) = 1.49-3.08, trend p = 0.009 and 0.0007, respectively]. After stratified by gender, the third tertile of early-age sun exposure was significantly associated with the SCC risk among men (OR = 3.08). The second and third tertiles of lifetime sun exposure was significantly associated with SCC risk among women (OR = 3.78 and 4.53, respectively). Skin reaction after 2-h sun exposure during childhood and adolescence was not significantly associated with the risk of SCC. Conclusions Lifetime sun exposure was more related to SCC risk in women, while early-age sun exposure was more relevant to men's SCC risk. This may be attributable to different lifestyle between men and women.

Original languageEnglish
Pages (from-to)771-776
Number of pages6
JournalCancer Causes and Control
Volume21
Issue number5
DOIs
Publication statusPublished - May 2010

Fingerprint

Solar System
Squamous Cell Carcinoma
Population
Odds Ratio
Life Style
Skin Neoplasms
Internship and Residency
Taiwan
Case-Control Studies
Logistic Models
Regression Analysis
Skin

Keywords

  • Early age
  • Lifetime
  • Squamous cell carcinoma (SCC)
  • Sun exposure

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Medicine(all)

Cite this

Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population. / Chen, Yen Ching; Christiani, David C.; Su, Huey Jen Jenny; Hsueh, Yu Mei; Smith, Thomas J.; Ryan, Louise M.; Chao, Sheau Chiou; Lee, Julia Yu Yun; Guo, Yue Liang Leon.

In: Cancer Causes and Control, Vol. 21, No. 5, 05.2010, p. 771-776.

Research output: Contribution to journalArticle

Chen, YC, Christiani, DC, Su, HJJ, Hsueh, YM, Smith, TJ, Ryan, LM, Chao, SC, Lee, JYY & Guo, YLL 2010, 'Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population', Cancer Causes and Control, vol. 21, no. 5, pp. 771-776. https://doi.org/10.1007/s10552-010-9505-x
Chen, Yen Ching ; Christiani, David C. ; Su, Huey Jen Jenny ; Hsueh, Yu Mei ; Smith, Thomas J. ; Ryan, Louise M. ; Chao, Sheau Chiou ; Lee, Julia Yu Yun ; Guo, Yue Liang Leon. / Early-life or lifetime sun exposure, sun reaction, and the risk of squamous cell carcinoma in an Asian population. In: Cancer Causes and Control. 2010 ; Vol. 21, No. 5. pp. 771-776.
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AU - Smith, Thomas J.

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N2 - Background It has been widely accepted that sun exposure is a risk factor of squamous cell carcinoma (SCC) among fair-skinned populations. However, sun exposure and sun reaction have not been explored in Asians and no gender-specific data were available. Method In a case-control study, 176 incident skin cancer cases were recruited from National Cheng-Kung University Medical Center from 1996 to 1999. Controls included 216 age-, gender-, and residency-matched subjects from the southwestern Taiwan. A questionnaire was administered to collect information on life style and other risk factors. Logistic regression analysis was performed to evaluate the association between sun exposure or sun reaction and the risk of SCC by gender. Results Early-age (age 15 to 24) and lifetime sun exposure were significantly associated with increased risk of SCC in a dose-response pattern [odds ratio (OR) = 1.49-3.08, trend p = 0.009 and 0.0007, respectively]. After stratified by gender, the third tertile of early-age sun exposure was significantly associated with the SCC risk among men (OR = 3.08). The second and third tertiles of lifetime sun exposure was significantly associated with SCC risk among women (OR = 3.78 and 4.53, respectively). Skin reaction after 2-h sun exposure during childhood and adolescence was not significantly associated with the risk of SCC. Conclusions Lifetime sun exposure was more related to SCC risk in women, while early-age sun exposure was more relevant to men's SCC risk. This may be attributable to different lifestyle between men and women.

AB - Background It has been widely accepted that sun exposure is a risk factor of squamous cell carcinoma (SCC) among fair-skinned populations. However, sun exposure and sun reaction have not been explored in Asians and no gender-specific data were available. Method In a case-control study, 176 incident skin cancer cases were recruited from National Cheng-Kung University Medical Center from 1996 to 1999. Controls included 216 age-, gender-, and residency-matched subjects from the southwestern Taiwan. A questionnaire was administered to collect information on life style and other risk factors. Logistic regression analysis was performed to evaluate the association between sun exposure or sun reaction and the risk of SCC by gender. Results Early-age (age 15 to 24) and lifetime sun exposure were significantly associated with increased risk of SCC in a dose-response pattern [odds ratio (OR) = 1.49-3.08, trend p = 0.009 and 0.0007, respectively]. After stratified by gender, the third tertile of early-age sun exposure was significantly associated with the SCC risk among men (OR = 3.08). The second and third tertiles of lifetime sun exposure was significantly associated with SCC risk among women (OR = 3.78 and 4.53, respectively). Skin reaction after 2-h sun exposure during childhood and adolescence was not significantly associated with the risk of SCC. Conclusions Lifetime sun exposure was more related to SCC risk in women, while early-age sun exposure was more relevant to men's SCC risk. This may be attributable to different lifestyle between men and women.

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